The Department of Internal Medicine is the largest department at Aga Khan University. Our Department is comprised of multiple sub-specialties with diverse faculty trained both locally and internationally. Our faculty, residents and staff at Aga Khan University, Nairobi are committed to ensuring top-notch patient-centered health care and patient safety, excellence in education and dedication to cutting-edge research.

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Submissions from 2017

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Plexiform Fibromyxoma: A Rare Gastric Tumor, Casmir Wambura and Salim Surani

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Most people in Africa don’t have access to palliative care. This needs to change, John Weru

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What Kenya needs to do to end the taboo of talking about ‘end of life care’, John Weru

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Complementary and Alternative Medicine Use in Rheumatoid Arthritis: Considerations for the Pharmacological Management of Elderly Patients, Sizheng Zhao, Fred Otieno, Asan Akpan, and Robert J. Moots

Submissions from 2016

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Is facility based neonatal care in low resource setting keeping pace? A glance at Uganda’s National Referral Hospital, Yaser Abdallah, Flavia Namiiro, Jamir Mugalu, Jolly Nankunda, Yvonne Vaucher, and Douglas McMillan

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Profile and Determinants of Neurocognitive Dysfunction in a Sample of Adult Nigerians With Heart Failure, Philip Adebayo, Akintunde Adeseye, Morenike Bosede Audu, Olugbenga Edward Ayodele, Rufus Olushola Akinyemi, and Oladimeji George Opadijo

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Comparison of Neuropsychological Patterns in Nigerians with different Heart Failure Phenotypes, Philip Adebayo, Adeseye A. Akintunde, Anthonia J. Anthonia, Stephen O. Asaolu, Morenike Audu, and Olugbenga E. Ayodele

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Sensitivity and Specificity of Respiratory Symptoms and Clinical Signs for Abnormal Spirometry among HIV+ Individuals in Kenya, Engi F. Attia, Elizabeth Maleche-Obimbo, Nelly Yatich, Lilian Ndukwe, Sameh Sakr, Neveen G. El Antouny, Michael Chung, and Kristina A. Crothers

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Associations between lifetime potentially traumatic events and chronic physical conditions in the South African Stress and Health Survey: a cross-sectional study, Lukoye Atwoli, Jonathan M. Platt, Archana Basu, David R. Williams, Dan J. Stein, and Karestan C. Koenen

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Posttraumatic stress disorder associated with unexpected death of a loved one: Cross-national findings from the world mental health surveys, Lukoye Atwoli, Dan J. Stein, Andrew King, Maria Petukhova, Sergio Aguilar-Gaxiola, Jordi Alonso, Evelyn J. Bromet, Giovanni de Girolamo, Koen Demyttenaere, and Silvia Florescu

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The Association between Asymptomatic and Mild Neurocognitive Impairment and Adherence to Antiretroviral Therapy amongst people living with HIV, Violet Maloba Awori

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The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium, Corina Benjet, E Bromet, E G. Karam, R C. Kessler, K A. McLaughlin, A M. Ruscio, V Shahly, D J. Stein, M Petukhova, E Hill, J Alonso, Lukoye Atwoli, B Bunting, R Bruffaerts, and J M. Caldas-de-Almeida

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RAS Mutation Predicts Positive Resection Margins and Narrower Resection Margins in Patients Undergoing Resection of Colorectal Liver Metastases, Kristoffer Watten Brudvik, Yoshihiro Mise, Michael Chung, Yun Shin Chun, Scott E. Kopetz, Guillaume Passot, Claudius Conrad, Dipen M. Maru, Thomas A. Aloia, and Jean-Nicolas Vauthey

Beyond the bull's eye: Recognizing Lyme disease, Gerard Chaaya, Juan J. Jaller, and Sayed Karar

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Increasing HIV-1 pretreatment drug resistance among antiretroviral-naïve adults initiating treatment between 2006 and 2014 in Nairobi, Kenya, Michael Chung, Silverman Rachel, Beck Ingrid, Yatich Nelly, Dross Sandra, Jennifer McKernan-Mullin, Stephen Bii, Kenneth Tapia, Joshua Stern, Chohan Bhavna, Samah R. Sakr, and James N. Kiarie

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Implementation of HIV Drug Resistance Testing in Kenya, Horacio Duarte, Ingrid Beck, James Munyao, Molly Levine, Catherine Kiptinness, Bhavna Chohan, Samah Sakr, Michael Chung, and Lisa Frenkel

Beyond the bull's eye: Recognizing Lyme disease, Chaaya Gerard, Juan J. Jaller-Char, and Sayed Karar

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Prevalence of Schistosoma mansoni and its clinical relevance at a primary health care level in rural lake zone of Tanzania: a cross sectional study, Daniel W. Gunda, Semvua B. Kilonzo, Fatma Bakshi, Charles M. Mguta, and Bonaventura \ C.T. Mpondo

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Short Communication: Analysis of Minor Populations of Human Immunodeficiency Virus by Primer Identification and Insertion-Deletion and Carry Forward Correction Pipelines, Paul Hughes, Wenjie Deng, Scott C. Olson, Robert W. Coombs, Michael Chung, and Lisa M. Frenkel

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Malignant Pervascular Epitheloid Cell Tumor (PEComa), Presenting as a Large Intra-Abdominal Mass in a Young Woman: A Case Report and Review of Literature, Asim Jamal, Majid Sikosana, Samuel Nguku, and Zahir Moloo

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Painless acute myocardial infarction on Mount Kilimanjaro, Nasiruddin Jama, Mubina Rajhy, and Mustaafa Bapumia

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The Diagnostic Accuracy Of Determine™ Tb Lam Antigen in Detection of Extra Pulmonary Tuberculosis (EPTB), Fatimah Osman Juma

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A fatty cough, Sayed Karar and Hammad Bhatti

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Electroencephalographic features of convulsive epilepsy in Africa: A multicentre study of prevalence, pattern and associated factors, Symon Kariuki and et al

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Diagnostic Accuracy of Ultrasound B scan using 10 MHz linear probe in ocular trauma;results from a high burden country, Muhammad KashifShazlee, Muhammad Ali, Muhammad Saad Ahmed, Ammad Hussain, Kamran Hameed, Irfan Amjad Lutfi, and Muhammad Tahir Khan

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Renal dysfunction among adult patients in Mwanza, Tanzania: prevalence, outcomes and associated factors, Semvua B. Kilonzo, Abdulraassul T. Seiffudin, Fatma Bakshi, and Daniel W. Gunda

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A case of refractory thrombotic thrombocytopenic purpura treated with plasmapheresis and rituximab, Nicholas Kirui and Ahmed Sokwala

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Risk factors, Clinico-Pathologic Characteristics and Outcomes in Young Kenyan Female Patients with Breast Cancer in AKUH-N, Gilford Mutwiri Mwikamba

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What change in outcomes after cardiac arrest is necessary to change practice? Results of an international survey, Graham Nichol, Siobhan P. Brown, Gavin D. Perkins, Francis Kim, Fritz Sterz, Jo Ann Broeckel Elrod, Spyros Mentzelopoulos, Richard Lyon, Yaseen Arabi, Maaret Castren, Peter Larsen, Terence Valenzuela, Jan-Thorsten Graesner, Scott Youngquist, Nalinas Khunkhlai, Henry E. Wang, Franek Ondrej, Juan Manuel Fraga Sastrias, Anders Barasa, and Michael R. Sayre

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Factors that Influence Advance Directives Completion amongst Terminally Ill Patients at AKUHN, Stephen Omondi Otieno

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Simplified Paper Format for Detecting HIV Drug Resistance in Clinical Specimens by Oligonucleotide Ligation, Nuttada Panpradist, Ingrid A. Beck, Michael Chung, James N. Kiarie, Lisa M. Frenkel, and Barry R. Lutz

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Symptoms in women with Peripartum Cardiomyopathy: A mixed method study, Harshida Patel, Marie Berg, Anders Barasa, Cecily Begley, and Maria Schaufelberger

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Clinical care of incarcerated people with HIV, viral hepatitis, or tuberculosis, Josiah D. Rich, Curt G. Beckwith, Alexandria Macmadu, Brandon D L Marshall, Lauren Brinkley-Rubinstein, Joseph J. Amon, M-J Milloy, Maximilian R F King, Jorge Sanchez, and Lukoye Atwoli

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Epilepsy Prevalence, Treatment Gap, and Stigma in Western Kenya (P1.272), Dilraj Sokhi, Monica Diaz, Anthony Ngugi, Tom Solomon, Eric Fevre, and Anna-Claire Meyer

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Post-traumatic stress disorder associated with life-threatening motor vehicle collisions in the WHO World Mental Health Surveys, Dan J. Stein, Elie G. Karam, Victoria Shahly, Eric D. Hill, Andrew King, Maria Petukhova, Lukoye Atwoli, Evelyn J. Bromet, Silvia Florescu, and Josep Maria Haro

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Partner Disclosure and Early CD4 Response among HIV-Infected Adults Initiating Antiretroviral Treatment in Nairobi Kenya, T. Tony Trinh, Nelly Yatich, Richard Ngomoa, Christine J. McGrath, Barbra A. Richardson, Samah R. Sakr, Agnes Langat, Grace C. John-Stewart, and Michael Chung

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Outcomes in Patients with Acute Coronary Syndromes at The Aga Khan University Hospital, Nairobi, Mohamed Hasham Varwani

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Telephone versus Face to Face Palliative Care Consults during Referral, John Weru

Submissions from 2015

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The Prevalence, Risk Factors and Changes in Symptoms of Self Reported Asthma, Rhinitis and Eczema Among Pregnant Women in Ogbomoso, Nigeria, Adewale Samson Adeyemi,; Adeolu Oladayo Akinboro; Philip Adebayo; Moses O. Tanimowo; and Olugbenga Edward Ayodele

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Task-shifting training improves stroke knowledge among Nigerian non-neurologist health workers, Rufus O. Akinyemi, Mayowa O. Owolabi, Philip Adebayo, Joshua O. Akinyemi, and Folajimi M. Otubogun

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Association between witnessing traumatic events and psychopathology in the South African Stress and Health Study, Lukoye Atwoli, Jonathan Platt, David R. Williams, Dan J. Stein, and Karestan C. Koenen

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Epidemiology of posttraumatic stress disorder: prevalence, correlates and consequences, Lukoye Atwoli, Dan Stein, Karestan C. Koenen, and Katie A. Mclaughlin

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Large scale genetic research on neuropsychiatric disorders in african populations is needed, Shareefa Dalvie, Nastassja Koen, Laramie Duncan, Catherine Abbo, Dickens Akena, Lukoye Atwoli, Bonginkosi Chiliza, Kirsten A. Donald, Eugene Kinyanda, and Christine Lochner

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Development of the roadmap and guidelines for the prevention and management of high blood pressure in Africa: Proceedings of the PASCAR: Hypertension task force meeting: Nairobi, Kenya, Anastase Dzudie, Dike Ojji, Benedict Chukwuemeka Anisiuba, Serigne Abdou, Ruth Cornick, Albertino Damasceno, Abdoul Kane, Ana Ogla Mocumbi, Awad Mohamed, George Nel, Elijah Ogola, Basden Onwubere, Harun Otieno, Brian Rainer, Aletta Schutte, Ibrahim Toure Ali, Marc Twagirumukiza, Neil Poulter, and Bongani Mayosi

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Pulmonary cryptococcosis presenting as acute severe respiratory distress in a newly diagnosed HIV patient in Tanzania: a case report, Gunda W. Gunda, Fatma Bakshi, Peter Rambau, and Semvua B. Kilonzo

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Methylation Levels of CADM1, MAL, and MIR124-2 in Cervical Scrapes for Triage of HIV-Infected, High-Risk HPV-Positive Women in Kenya., De Vuyst Hugo, Franceschi Silvia, Plummer Martyn, Nelly R. Mugo, Samah R. Sakr, Chris J. L. M. Meijer, Daniëlle A. M. Heideman, Vanessa Tenet, Peter J. F. Snijders, Albertus T. Hesselink, and Michael Chung

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Dual antiplatelet agents and Rivaroxaban for massive intracoronary thrombus in STEMI, Nasiruddin Jamal and Mustaafa Bapumia

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Not So Grand Rounds, Sayed Karar and Haritha Saikumar

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Does upgrade to tri-ventricular pacemaker improve long-term clinical response in non-responders to biventricular cardiac resynchronization therapy?, Sharon Hw Man, Jeilan Mohamed, Shoaib Siddiqui, and G. André Ng

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Respiratory function amongst asymptomatic HIV positive and HIV negative clients at Aga Khan University Hospital, Nairobi, Noah Kipkemei Murbiy

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Gender differences in clinical characteristics and outcome of acute heart failure in sub-Saharan Africa: results of the THESUS-HF study, Okechukwu S. Ogah, Beth A. Davison, Karen Sliwa, Bongani M. Mayosi, Albertino Damasceno, Mahmoud U. Sani, Charles Mondo, Anastase Dzudie, Dike B. Ojji, Charles Kouam, Ahmed Suliman, Neshaad Schrueder, Gerald Yonga, Sergine Abdou Ba, Fikru Maru, Bekele Alemayehu, Christopher Edwards, and Gad Cotter

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Association between traumatic events and post-traumatic stress disorder: results from the ESEMeD-Spain study, B Olaya, J Alonso, Lukoye Atwoli, R C. Kessler, G Vilagut, and J M. Haro

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Symptoms of depression among patients attending a diabetes care clinic in rural western Kenya, Kristen Shirey, Simon M. Manyara, Lukoye Atwoli, Ryan Tomlin, Benson Gakinya, Stephanie Cheng, Jemima Kamano, Jeremiah Laktabai, and Sonak Pastakia

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Comparison of cardiovascular risk profiles amongst newly diagnosed cancer patients and non-cancer patients at the Aga Khan University Hospital Nairobi, Majid Lingani-Ncube Sikosana

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Mortality Across Two ART Trials Enrolling at ≤200 vs ≤350 CD4 cells/uL in Kenya, Rachel A. Silverman, Michael Chung, James N. Kiarie, Nelly Yatich, Julia Njoroge, Catherine Kiptiness, Samah Sakr, Grace John-Stewart, and Lisa Frenkel

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Atrial fibrillation in sub-saharan Africa: epidemiology, unmet needs, and treatment options, Bruce Sheldon Stambler and Mzee Ngunga

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Characterization of in-hospital cardiac arrest in adult patients at a tertiary hospital in Kenya, Benjamin Wachira

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Uchunguzi (Journal Watch/Montre de journal) June 2015, Benjamin Wachira

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Uchunguzi (Journal WatchMontre de Journal) March 2015, Benjamin Wachira

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Uchunguzi (Journal Watch/Montre de journal) September 2015, Benjamin Wachira

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Building comprehensive and sustainable health informatics institutions in developing countries: Moi University experience, Martin C. Were, Abraham Siika, Paul O. Ayuo, Lukoye Atwoli, and Fabian Esamai

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Initial Impressions and Review of Literature Concerning Factors Affecting the Use of Palliative Care Assessment Tools in an African Setting, John Weru

Submissions from 2014

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Impact of somatic comorbidities on quality of life of patients living with epilepsy in Sagamu, Nigeria, Philip Adebayo, Rufus O. Akinyemi, Folashade Oluwole, Shamsideen A. Ogun, and Adesola Ogunniyi

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Gestational headaches: characteristics and influencing factors in SouthWestern Nigeria, Philip Adebayo, Aramide Mikhail Tijani, Olukayode Abayomi, and Adeseye Abiodun Akintunde

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Incidence and risk factors for acute myocardial injury after non-cardiac surgery at the Aga Khan University hospital Nairobi, Salim Said Ahmed

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Impact of domestic care environment on trauma and posttraumatic stress disorder among orphans in western Kenya, Lukoye Atwoli, David Ayuku, Joseph Hogan, Julius Koech, Rachel Christine Vreeman, Samuel Ayaya, and Paula Braitstein

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The government of Kenya cash transfer for orphaned and vulnerable children: cross-sectional comparison of household and individual characteristics of those with and without, Lukoye Atwoli, Lonnie Embleton, Julius Koech, Paula Braitstein, and Allan Kamanda

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Association between parental psychopathology and suicidal behavior among adult offspring: results from the cross-sectional South African Stress and Health survey, Lukoye Atwoli, Matthew K. Nock, David R. Williams, and Dan J. Stein

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Rationale and design of the Pan-African sudden cardiac death survey: The Pan-African SCD study, Aimé Bonny, Marcus Ngantcha, Sylvie Ndongo Amougou, Adama Kane, Sonia Marrakchi, Emmy Okello, Georges Taty, Abdulrrazzak Gehani, Mamadou Diakite, Mohammed Talle, Pier Lambiase, Martin Houenassi, Ashley Chin, Harun Otieno, Gloria Temu, Isaac Koffi Owusu, Kamilu Karaye, Abdalla AM Awad, Bo Bo Gregers Winkel, and Silvia Priori

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Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya, Michael Chung, Ingrid A. Beck, Sandra Dross, Kenneth Tapia, James N. Kiarie, Barbra A. Richardson, Julie Overbaugh, Samah R. Sakr, Grace C. John-Stewart, and Lisa M. Frenkel

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Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients, Muhammad Ishaq, Jibran Sualeh Muhammad, Kamran Hamid, and Ahmad Iqbal Mirza Ahmad Iqbal Mirza

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Clinical features, proximate causes, and consequences of active convulsive epilepsy in Africa, Symon M. Kariuki, William Matuja, Albert Akpalu, Angelina Kakooza-Mwesige, Martin Chabi, Ryan G. Wagner, Myles Connor, Eddie Chengo, Anthony K. Ngugi, Rachael Odhiambo, Christian Bottomley, Steven White, Josemir W. Sander, Brian G. R. Neville, and Charles R. J. C. Newton

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Effect of surgical subspecialty training on patent ductus arteriosus ligation outcomes, Dor Markush, Kelleigh E. Briden, Michael Chung, Katherine W. Herbst, Trudy J. Lerer, Stephen Neff, Amy C. Wu, and Brendan T. Campbell

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Interventions to promote adherence to antiretroviral therapy in Africa: a network meta-analysis, Edward J. Mills, Richard Lester, Kristian Thorlund, Maria Lorenzi, Katherine Muldoon, Steve Kanters, Sebastian Linnemayr, Robert Gross, Yvette Calderon, K Rivet Amico, Harsha Thirumurthy, Cynthia Pearson, Robert H. Remien, Lawrence Mbuagbaw, Lehana Thabane, Michael Chung, Ira B. Wilson, Albert Liu, Olalekan A. Uthman, Jane Simoni, David Bangsberg, Sanni Yaya, Till Bärnighausen, Nathan Ford, and Jean B. Nachega

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Comparison of cardiometabolic risk profile between HIV patients on art and those who are art naïve, Erick Kimani Njenga

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Machado–Joseph disease in a Nigerian family: mutational origin and review of the literature, Shamsideen Abayomi Ogun, Sandra Martins, Philip Adebayo, Clara O. Dawodu, Jorge Sequeiros, and Michael F. Finkel

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Prevalence and clinical characteristics of venous thromboembolism at the Aga Khan University hospital, Nairobi, Felix Mutuma Riunga

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DSM‐5 and ICD‐11 definitions of posttraumatic stress disorder: Investigating “narrow” and “broad” approaches, Dan J. Stein, Katie A. McLaughlin, Karestan C. Koenen, Lukoye Atwoli, Matthew J. Friedman, Eric D. Hill, Andreas Maercker, Maria Petukhova, Victoria Shahly, and Mark van Ommeren

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Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits, Gert U. van Zyl, Lisa M. Frenkel, Michael Chung, Wolfgang Preiser, John W. Mellors, and Jean B. Nachega

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Acute management of ST-elevation myocardial infarction in a tertiary hospital in Kenya: are we complying with practice guidelines?, Benjamin Wachira, Andrew Owuor, and Harun Otieno

Submissions from 2013

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HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort, Syed Hani Abidi, Aniqa Shahid, Laila S. Lakhani, Reena Shah, Nancy Okinda, Peter Ojwang, Farhat Abbas, Sarah Rowland-Jones, and Syed Ali

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Breaking bad news in clinical setting - health professionals' experience and perceived competence in southwestern Nigeria: A cross sectional study, Philip Adebayo, Olukayode Abayomi, Peter O. Johnson, Taofeeq Oloyede, and Abimbola A. Oyelekan

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Neuropsychiatric and Parkinsonian manifestations of dementia: A case report in a Nigerian woman, Philip Adebayo, Ajan A. Ajani, Olaleye A. Adenij, and Rufus O. Akinyemi

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Anthropometric differences among natives of Abuja living in urban and rural communities: correlations with other cardiovascular risk factors, Olufemi Sola Adediran, Philip Adebayo, and Adeseye Abiodun Akintunde

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Carotid atherosclerosis and right ventricular diastolic dysfunction in a sample of hypertensive Nigerian patients, Adeseye A. Akintunde, Philip Adebayo, Ademola A. Aremu, and Oladimeji G. Opadijo

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Trauma and posttraumatic stress disorder in South Africa: analysis from the South African Stress and Health Study, Lukoye Atwoli, Dan J. Stein, David R. Williams, Katie A. Mclaughlin, Maria Petukhova, Ronald C. Kessler, and Karestan C. Koenen

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Comparing Papanicolau smear, visual inspection with acetic acid and human papillomavirus cervical cancer screening methods among HIV-positive women by immune status and antiretroviral therapy, Michael Chung, K. P. McKenzie, H. D. Vuyst, B. A. Richardson, Farzana Rana, R. Pamnani, J. W. Njoroge, E. Nyongesa-Malava, S. R. Sakr, G. C. John-Stewart, and N. R. Mugo

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The journey of addiction: Barriers to and facilitators of drug use cessation among street children and youths in Western Kenya, Lonnie Embleton, Lukoye Atwoli, David Ayuku, and Paula Braitstein

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Harnessing the power of the grassroots to conduct public health research in sub-Saharan Africa: a case study from western Kenya in the adaptation of community-based participatory research (CBPR) approaches, Allan Kamanda, Lonnie Embleton, David Ayuku, Lukoye Atwoli, Peter Gisore, Samuel Ayaya, Rachel Vreeman, and Paula Braitstein

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Effect of mobile phone short message service on adherence rates to antihypertensives at the Family Medicine Clinic, Barbara Karau

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The muranga teleophthalmology study: comparison of virtual (teleglaucoma) with in-person clinical assessment to diagnose glaucoma, Dan Kiage, Irfan N. Kherani, Stephen Gichuhi, Karim F. Damji, and Muindi Nyenze

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Prevalence and factors associated with depression among patients with epilepsy in a Kenyan tertiary care hospital, Nduku Kiko

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Substance use among inmates at the Eldoret prison in Western Kenya, Daniel WC Kinyanjui and Lukoye Atwoli

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Improving diabetic retinopathy screening in Africa: Patient satisfaction with teleophthalmology versus ophthalmologist-based screening, K. Kurji, D. Kiage, C. J. Rudnisky, and K. F. Damji

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The prevalence of post-traumatic stress disorder among sexually abused children at kenyatta national hospital in Nairobi, Kenya, C. A. OMBOK, A. Obondo, and Lukoye Atwoli

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Clinical characteristics and outcomes of atrial fibrillation and flutter at the Aga Khan University Hospital, Nairobi, Jay Shavadia, Gerald Yonga, Sitna Mwanzi, Ashna Jinah, Abednego Moriasi, and Harun Otieno

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Readmission and death after an acute heart failure event: predictors and outcomes in sub-saharan africa: results from the thesus-hf registry, K. Sliwa, B. A. Davison, B. M. Mayosi, A. Damasceno, M. Sani, O. S. Ogah, C. Mondo, D. Ojji, A. Dzudie, C. K. Kouam, A. Suliman, N. Schrueder, Gerald Yonga, S. A. Ba, F. Maru, B. Alemayehu, C. Edwards, and G. Cotter

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Major incidents in Kenya: the case for emergency services development and training, Benjamin Wachira and Wayne Smith

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The prevalence of smoking and the knowledge of smoking hazards and smoking cessation strategies among hiv positive patients in johannesburg, south africa, Peter Waweru, R. Anderson, H. Steel, WDF. Venter, D. Murdoch, and C. Feldman

Submissions from 2012

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Short-term diagnostic stability among re-admitted psychiatric in-patients in Eldoret, Kenya, Lukoye Atwoli, D. Ndambuki, P. OWITI, G. Manguro, and N. Omulimi