The Department of Internal Medicine is the largest department at Aga Khan University. Our Department is comprised of multiple sub-specialties with diverse faculty trained both locally and internationally. Our faculty, residents and staff at Aga Khan University, Nairobi are committed to ensuring top-notch patient-centered health care and patient safety, excellence in education and dedication to cutting-edge research.

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Submissions from 2020

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Is pollen‐food syndrome a frequent comorbidity in adults with irritable bowel syndrome?, Kirtika Patel, Gemma Vila‐Nadal, Jasmit Shah, Mohamed H. Shamji, Lorna Swan, Stephen R. Durham, Kinesh Patel, and Isabel J. Skypala

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The impact of scaling up cervical cancer screening and treatment services among women living with HIV in Kenya: a modelling study, Pablo Noel Perez-Guzman, Michael Chung, Hugo De Vuyst, Shona Dalal, Kennedy K. Mutai, Karanja Muthoni, Bartilol Kigen, Timothy B. Hallett, and Mikaela Smit

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Benign Recurrent Intrahepatic Cholestasis (BRIC): An African Case Report, Adil Salyani, Linda Barasa, Allan Rajula, and Sayed Karar

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Occult hepatitis b virus infection in a cohort of HIV infected antiretroviral therapy naïve adults, Adil Suleiman Salyani

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Effect of UNMASKES on Delivering Difficult News among Residents, Karishma Sharma

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Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis, Karishma Sharma, Fredrick Otieno, and Reena Shah

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Qualitative Approach to Understanding Barriers to Delivering Difficult News in Sub Saharan Africa, Karishma Sharma, Jasmit Shah, and Sayed Karar

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Towards mental health friendly cities during and after COVID-19, Moitreyee Sinha, Manasi Kumar, Lian Zeitze, Pamela Y. Collins, Suresh Kumar, Steve Fisher, Nathaniel Foote, Norman Sartorius, Helen Herrman, and Lukoye Atwoli

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Autoimmune Encephalitis is Recognised as an Important Differential Diagnosis in a Kenyan Tertiary Referral Centre, Dilraj Sokhi and Onkar Singh Bhogal

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Development of a framework for minimum and optimal safety and quality standards for hemodialysis and peritoneal dialysis, Laura Sola, Nathan W. Levin, David W. Johnson, Roberto Pecoits-Filho, Harith M. Aljubori, Yuqing Chen, Stefaan Claus, Allan Collins, Brett Cullis, and Ahmed Twahir

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Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania, Samina Somji, Pascal Ruggajo, and Sibtain Moledina

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Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania, Samina Somji, Pascal Ruggajo, and Sibtain Moledina

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Adequacy of hemodialysis and its associated factors among patients undergoing chronic hemodialysis in dar es Salaam, Tanzania., Samina S. Somji, Paschal Ruggajo, and Sibtain Moledina

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Pre-marital predictors of marital violence in the WHO World Mental Health (WMH) Surveys, Cara M. Stokes, Jordi Alonso, Laura Helena Andrade, Lukoye Atwoli, Graça Cardoso, Wai Tat Chiu, Rumyana V. Dinolova, Oye Gureje, Aimee N. Karam, and Elie G. Karam

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Reliability and validity of the RS14 in orphaned and separated adolescents and youths in western Kenya, Sarah C. Sutherland, Harry S. Shannon, David Ayuku, David L. Streiner, Olli Saarela, Lukoye Atwoli, and Paula Braitstein

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Post-Vaccination Pharyngeal-Cervical-Brachial Variant of Guillain-Barré Syndrome, Funmilola T. Taiwo, Daniel E. Ezuduemoih, and Philip Adebayo

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Developing Ethical and Sustainable Global Health Educational Exchanges for Clinical Trainees: Implementation and Lessons Learned from the 30-Year Academic Model Providing Access to Healthcare (AMPATH) Partnership, Matthew Turissini, Tim Mercer, Jenny Baenziger, Lukoye Atwoli, Robert Einterz, Adrian Gardner, Debra Litzelman, and Paul Ayuo

Developing Ethical and Sustainable Global Health Educational Exchanges for Clinical Trainees: Implementation and Lessons Learned from the 30-Year Academic Model Providing Access to Healthcare (AMPATH) Partnership, Matthew Turissini, Tim Mercer, Jenny Baenziger, Lukoye Atwoli, Robert Einterz, Adrian Gardner, Debra Litzelman, Debra Litzelman, and Paul Ayuo

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Etiology, Treatment and Outcomes in Patients With Left Ventricular Thrombus - Experiences From an African Center, Mohamed Varwani, Jeilan Mohamed, Jasmit Shah, and Mzee Ngunga

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Revisiting Caroli Syndrome in a Tanzanian Patient, Casmir Wambura; Sharma, Munishi; and Salim Suran

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Revisiting Caroli Syndrome in a Tanzanian Patient, Casmir Wambura, Munish Sharma, and Salim Surani

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Randomized control trial of advanced cancer patients at a private hospital in Kenya and the impact of dignity therapy on quality of life, John Weru, Miriam Gatehi, and Alice Musibi

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Provision of Palliative Care Services for Cancer Patients in the Community in Africa, John Weru and Esther W. Nafula

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Primitive neuroectodermal tumor incidence, treatment patterns, and outcome: An analysis of the National Cancer Database, Matthew R. Woeste, Neal Bhutiani, Young K. Hong, Jasmit Shah, Woihwan Kim, Michael E. Egger, Prejesh Philips, Kelly M. McMasters, Robert C. G. Martin, and Charles R. Scoggins

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Global case studies for chronic kidney disease/end-stage kidney disease care, Chih-Wei Yang, David C.H. Harris, Valerie A. Luyckx, Masaomi Nangaku, Fan Fan Hou, Guillermo Garcia Garcia, Hasan Abu-Aisha, Abdou Niang, Laura Sola, and Ahmed Twahir

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Inadvertent Stone Migration During Pneumatic Lithotripsy: Still a Conundrum in the 21st Century, Ali Akbar Zehri, Miten Patel, Philip Adebayo, and Authar Ali

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Inadvertent Stone Migration During Pneumatic Lithotripsy: Still a Conundrum in the 21st Century, Ali Akbar Zehri, Miten Patel, Philip Adebayo, and Authar Ali

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Inadvertent Stone Migration During Pneumatic Lithotripsy: Still a Conundrum in the 21st Century, Ali Akbar Zehri, Miten Patel, Philip Adebayo, and Authar Ali

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Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury, Jingjing Zhao, Daniel J. Conklin, Yiru Guo, Xiang Zhang, Detlef Obal, Luping Guo, Ganapathy Jagatheesan, Kartik Katragadda, Liqing He, and Jasmit Shah

Theses/Dissertations from 2019

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Eligibility and patient barriers to peritoneal dialysis in patients with advanced chronic kidney disease, Saleem Mohamed Abdulkarim

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Adult-onset Still’s disease triggered by pregnancy, Saleem Abdulkarim, Fredrick Otieno, and Sayed Karar

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Factors associated with cardiac dysfunction following anthracyline-based chemotherapy in adults in a tertiary hospital in Nairobi, Joseph Odunga Abuodha

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A delay in diagnosis: thrombotic thrombocytopenia purpura occurring in systemic lupus erythematous, Zoya Adam, Ahmed Sokwala, Jasmit Shah, and Sayed Karar

Pick’s disease and subdural haematoma: A diagnostic red herring, Philip Adebayo, Funmilola Taiwo, Fatma Bakshi, and Sunham Nur

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Differential impact of risk factors on stroke occurrence among men versus women in West Africa: the SIREN study, Albert Akpalu, Mulugeta Gebregziabher, Bruce Ovbiagele, Fred Sarfo, Henry Iheonye, Rufus Akinyemi, Onoja Matthew Akpa, Hemant K. Tiwari, Kolawole W. Wahab, and Philip Adebayo

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The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda, Violet Awori, Gertrude Nakigozi, Alice Kisakye, James Batte, Aggrey Anok, Richard Mayanja, Noeline Nakasujja, Kevin R. Robertson, Ronald H. Gray, and Maria J. Wawer

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Metastatic Breast Cancer in Kenya: Presentation, Pathologic Characteristics, and Patterns-Findings From a Tertiary Cancer Center, Etoroabasi Ekpe, Asim Jamal, Jasmit Shah, Judith S. Jacobson, and Shahin Sayed

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A Study to Assess the Relationship between Attention Deficit Hyperactivity Disorder and Obstructive Sleep Apnea in Adults, Sean Hesselbacher, Akshar A. Aiyer, Salim R. Surani, Alishah A. Suleman, and Joseph Varon

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Cardiovascular risk factors among people living with HIV in rural Kenya: a clinic-based study, Kenneth Juma, Roseanne Nyabera, Sylvia Mbugua, George Odinya, James Jowi, Mzee Ngunga, David Zakus, and Gerald Yonga

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Fostering productive conversations in a Kenyan tertiary intensive care unit: lessons learnt, Sayed Karar, Jamila Nambafu, and Feroza Daroowalla

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Using CIRUPA to Help Foster Communication with Families about Brain Death in Sub‑Saharan Africa, Sayed Karar, Anthony Ochola, Fatima Juma, and Feroza Daroowalla

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Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI), David G. Kiely, David L. Levin, Paul M. Hassoun, Dunbar Ivy, Pei-Ni Jone, Jumaa Bwika, Steven M. Kawut, Jim Lordan, Angela Lungu, and Jeremy A. Mazurek

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Cytological diagnosis of cryptococcosis in a biliary specimen: Report of a rare case with brief review of literature, Neeta Kumar, Ruchika Gupta, Shahin Sayed, Zahir Moloo, Rodney Adam, Gunturu Revathi, and Smita Devani

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Global burden of atherosclerotic cardiovascular disease in people with hepatitis C virus infection: a systematic review, meta-analysis, and modelling study, Kuan Ken Lee, Dominik Stelzle, Rong Bing, Mohamed Anwar, Fiona Strachan, Sophia Bashir, David E. Newby, Jasmit Shah, Michael Chung, and Gerald S. Bloomfield

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Randomized controlled trial of influenza vaccine in patients with heart failure to reduce adverse vascular events (IVVE): Rationale and design, Mark Loeb, Hisham Dokainish, Antonio Dans, Lia M. Palileo-Villanueva, Ambuj Roy, Ambuj Roy, Kamilu Karaye, Jun Zhu, Yan Liang, and Gerald Yonga

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Prevalence and outcome of asymptomatic Cryptococcal antigenemia in art naive and art experienced HIV patients in Dar es salaam, Tanzania, Charles Mandela Makakala

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Minority and majority pretreatment HIV-1 drug resistance associated with failure of first-line nonnucleoside reverse-transcriptase inhibitor antiretroviral therapy in Kenyan women, Ross S. Milne, Rachel A. Silverman, Ingrid A. Beck, Jennifer Mckernan-Mullin, Wenjie Deng, Thomas R. Sibley, Sandra Dross, James N. Kiarie, Samah R. Sakr, and Michael Chung

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Clinical audit and outcomes of hyper-acute ischaemic stroke treatment in the largest regional cohort at a tertiary neurology referral centre in Nairobi, Kenya, Caroline Mithi, A. Vakil, Jasmit Shah, Benjamin Wachira, Edwin Mogere, and Dilraj Sokhi

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Barriers to definitive hyper-acute management of stroke at a tertiary facility in Nairobi, Kenya, Caroline Wangui Mithi

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May Measurement Month 2017: the results of blood pressure screening of 14 845 individuals in Kenya—Sub-Saharan Africa, Elijah N. Ogola, Felix Barasa, Anders Barasa, Bernard M. Gitura, Benson Njunguna, Thomas Beaney, Xin Xia, and Neil R. Poulter

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Healthy Heart Africa-Kenya: A 12-Month Prospective Evaluation of Program Impact on Health Care Providers' Knowledge and Treatment of Hypertension, Elijah N. Ogola, Francis O. Okello, Jane L. Herr, Elizabeth Macgregor-Skinner, Ashling Mulvaney, and Gerald Yonga

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Khat use and psychotic symptoms in a rural Khat growing population in Kenya: a household survey, Linnet Ongeri, Fredrick Kirui, Erastus Muniu, Veronica Manduku, Leah Kirumbi, Lukoye Atwoli, Safari Agure, Peter Wanzala, Lydia Kaduka, Mercy Karimi, Richard Mutisya, Elizabeth Echoka, Joseph Mutai, David Mathu, and Charles Mbakaya

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Pregabalin for Treatment of Docetaxel-Related Hand-Foot Syndrome, Kelvin Orare, Jamila Nambafu, Sitna Mwanzi, and Sayed Karar

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OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories, Nuttada Panpradist, Ingrid A. Beck, Justin Vrana, Nikki Higa, David McIntyre, Parker S. Ruth, Isaac So, Enos C. Kline, Ruth Kanthula, and Michael Chung

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Acinetobacter infections: a retrospective study to determine in hospital mortality rate and clinical factors associated with mortality, Rajiv Patel, Jasmit Shah, Gunturu Revathi, Wangari Siika, and Reena Shah

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Acinetobacter infections: a retrospective study to determine inhospital mortality rate and clinical factors associated with mortality, R. V. Patel, J. S. Shah, R Gunturu, W. Siika, and Reena Shah

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Utilization of healthcare services among Chinese migrants in Kenya: a qualitative study, Jialing Qiu, Duo Song, Juan Nie, Mengyi Su, Chun Hao, Jing Gu, Yuantao Hao, James N. Kiarie, and Michael Chung

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Disease activity and functional status and their relation to depression in patients with rheumatoid arthritis, Joe Rosana Rakiro

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Comparison of the sofa and qsofa scores in predicting in-hospital mortality among adult critical care patients with suspected Infection., Mohammed Said

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Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection, Mohammed A. Said, Wangari Siika, Vitalis Mung’ayi, and Reena Shah

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BayesMetab: treatment of missing values in metabolomic studies using a Bayesian modeling approach, Jasmit Shah, Guy N. Brock, and Jeremy Gaskins

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Delivering Difficult News in a Tertiary Hospital in Sub-Saharan Africa—A Consensus Study Among Residents, Karishma Sharma, Jasmit Shah, and Sayed Karar

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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda, Anne Stevenson, Dickens Akena, Rocky E. Stroud, Lukoye Atwoli, Megan M. Campbell, Lori B. Chibnik, Edith Kwobah, Symon M. Kariuki, Alicia R. Martin, and Victoria de Menil

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Access to care and financial burden for patients with breast cancer in Ghana, Kenya, and Nigeria, Majid Twahir, Rasaaq Adisa Oyesegun, Joel Yarney, Andrew Gachii, Clement Edusa, Chukwumere Nwogu, Gitangu Mangutha, Philip Anderson, Emmanuel Benjamin, Borna Müller, and Charles Ngoh

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Outcomes in patients with acute coronary syndrome in a referral hospital in sub-Saharan Africa, Mohamed Varwani, Jeilan Mohamed, Mzee Ngunga, and Anders Barasa

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Estimating the costs of HIV clinic integrated versus non-integrated treatment of pre-cancerous cervical lesions and costs of cervical cancer treatment in Kenya, Elisabeth L. Vodicka, Michael Chung, Marita R. Zimmermann, Rose J. Kosgei, Fan Lee, Nelly R Mugo R. Mugo, Timothy C. Okech, Samah R. Sakr, Andy Stergachis, Louis Garrison, and Joseph B. Babigumira

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Extension for Community Healthcare Outcomes-Palliative Care in Africa Program: Improving Access to Quality Palliative Care, Sriram Yennurajalingam, Charles E. Amos, John Weru, Edwina Beryl, Addo Opare-Lokko, Joseph Anthony Arthur, Kristy Nguyen, Olaitan Soyannwo, Runcie C.W. Chidebe, Janet L. Williams, Zhanni Lu, Ellen Baker, Sanjeev Arora, Eduardo Bruera, and Suresh Reddy

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Healthy Heart Africa: a prospective evaluation of programme outcomes on individuals' hypertension awareness, screening, diagnosis and treatment in rural Kenya at 12 months, Gerald Yonga, Francis O. Okello, Jane L. Herr, Ashling Mulvaney, and Elijah N. Ogola

Theses/Dissertations from 2018

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Long-term outcomes and factors associated with mortality among patients with moderate to severe pulmonary hypertension in Kenya, Abdulaziz Mansur Abeid

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EMG indications and findings in a sub-Saharan African neurorehabilitation center, Philip Adebayo, Funmilola T. Taiwo, and Mayowa O. Owolabi

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APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke, R Akinyemi, H K. Tiwari, D K. Arnett, B Ovbiagele, M R. Irvin, K Wahab, F. Sarfo, V Srinivasasainagendra, A AAdeoye, and Philip Adebayo

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Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project, Rufus O. Akinyemi, Kazeem Akinwande, Samuel Diala, Osi Adeleye, Abiodun Ajose, Kehinde Issa, Dorcas Owusu, Isaac Boamah, Isah Suleiman Yahaya, and Philip Adebayo

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The association between asymptomatic and mild neurocognitive impairment and adherence to antiretroviral therapy among people living with human immunodeficiency virus, Violet Awori, Peter Mativo, Gerald Yonga, and Reena Shah

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Constrictive Bronchiolitis Attributable to Inhalation of Toxic Agents: Considerations for a Case Definition., Daniel E. Banks, Caroline A. Bolduc, Sayed Karar, and Michael J. Morris

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Spontaneous regression of a primary squamous cell lung cancer following biopsy: a case report, Nathan Esplin, Khadija Fergiani, Timothy B. Legare, John W. Stelzer, Hammad Bhatti, and Sayed Karar

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A Randomized control trial of English-speaking advanced cancer patients at AKUs medical and surgical clinics and the impact on QOL of one session of Dignity Therapy, Miriam Gatehi-Muriithi

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Post-traumatic stress disorder, major depressive disorder and generalised anxiety disorder, among university students following a terrorist attack in Kenya, Florence Jaguga, Ann Mwangi, Mary Mahugu, Rogers Songole, Benson Gakinya, David Ayuku, Daniel Kinyanjui, Edith Kwobah, and Lukoye Atwoli

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Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect, Asim Jamal, Maeve Mullooly, Shahin Sayed, Rose Ndumia, Innocent Abayo, James Orwa, Ronald Wasike, Zahir Moloo, and Gretchen L. Gierach

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Improving Metastatic Breast Cancer Care in Kenya Using Information Technology, Asim Jamal, Shahin Sayed, C. Cathomi, and F. Chite

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Prevalence of Irritable Bowel Syndrome, Psychological Ill-Health and Health-Seeking Behavior in a Population of Nigerian Medical Students, Abiodun Christopher Jemilohun, Olukayode Abayomi, and Philip Adebayo

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Treatment of Anal Cancer Pain – A Case Report, Sayed Karar and Saleem Abdulkarim

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The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas, Ronald C. Kessler, Sergio Aguilar-Gaxiola, Jordi Alonso, Evelyn J. Bromet, Oye Gureje, Elie G. Karam, Karestan C. Koenen, Sing Lee, Howard Liu, Beth-Ellen Pennell, Maria Vladimirovna Petukhova, Nancy A. Sampson, Victoria Shahly, Dan J. Stein, and Lukoye Atwoli

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Hepatitis B Virus Infection in Tanzania: Current Status and Challenges, Semvua B. Kilonzo, Daniel W. Gunda, Bonaventura C. T. Mpondo, Fatma Bakshi, and Hyasinta Jaka

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Social work integration and performance of palliative care at the Aga Khan University Hospital, Nairobi County, Kenya, Cosmas Kipkoech, Johnson Mavole, Simon Ikonze Ndulu, and John Weru

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Substance use and universal access to HIV testing and treatment in sub-Saharan Africa: implications and research priorities, Kathryn E. Lancaster, Angela Hetrick, Antoine Jaquet, Adebola Adedimeji, Lukoye Atwoli, Donn J. Colby, Angel M. Mayor, Angela Parcesepe, and Jennifer Syvertsen

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Initial Rhythm and Resuscitation Outcomes for Patients Developing Cardiac Arrest in Hospital: Data From Low-Middle Income Country, Mzee Ngunga, Gerald Yonga, Benjamin Wachira, and Justin A. Ezekowitz

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Acinetobacter infections: a retrospective study to determine in – hospital mortality rate and clinical factors associated with mortality, Rajiv Patel

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Prevalence of HLA-B*5701 in a Kenyan population with HIV infection, Reena Shah, H. Nabiswa, Nancy Okinda, Gunturu Revathi, Mark Hawken, and Nelson M.

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Evaluation of alcohol screening and community-based brief interventions in rural western Kenya: a quasi-experimental study, Risa Takahashi, Calistus Wilunda, Karani Magutah, Wanja Mwaura-Tenambergen, Lukoye Atwoli, and Usaneya Perngparn

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Pseudomyxoma pleurii and peritonei secondary to sigmoid colon adenocarcinoma: a rare clinico-pathologico-radiological presentation, Casmir Wambura, Ahmed Jusabani, and Salim Surani

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ECHO palliative care in Africa (ECHO-PACA): Improving access to quality palliative care., Sriram Yennu, Charles E. Amos Jr, John Weru, Edwina Beryl Victoria, Joseph Anthony Arthur, Olaitan Soyannwo, Runcie C.W. Chidebe, Eduardo Bruera, and Suresh Reddy

Submissions from 2017

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Dyke–Davidoff–Masson syndrome in a Nigerian, Philip Adebayo, Amnat Bakare, Modupe M. Bello, Opeyemi D. Olaewe, and Kolawole W. Wahab

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P253 Knowledge of electromyography (EMG) among sub-Saharan African patients - A pilot survey, Philip Adebayo, Funmilola Taiwo, and Mayowa Owolabi

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Erectile dysfunction in men with and without lower urinary tract symptoms in Nigeria., Patrick Temi Adegun, Peter Olufemi Areo, Abidemi Solomon, Samuel Ayokunle Dada, and Philip Adebayo

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Exploring Overlaps Between the Genomic and Environmental Determinants of LVH and Stroke: A Multicenter Study in West Africa, Abiodun M. Adeoye, Bruce Ovbiagele, Philip Kolo, Lambert Appiah, Akinyemi Aje, Oladimeji Adebayo, Fred Sarfo, Joshua Akinyemi, Gregory Adekunle, and Philip Adebayo

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Interleukin–6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men, Rufus Akinyemi, Donna K. Arnett, Hemant K. Tiwari, Bruce O. Ovbiagele, Fred Sarfo, Vinodh Srinivasasainagendra, Marguerite Ryan Irvin, Abiodun Adeoye, Rodney T. Perry, and Philip Adebayo

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mHealth in palliative care for cancer patients & care givers, Newton Andebe, Peter Waiganjo, and John Weru

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Risk Factors for Hypoxia and Tachypnea Among Adolescents With Vertically-acquired HIV in Nairobi, Engi F. Attia, Noel S. Weiss, Elizabeth Maleche Obimbo, Christine J. McGrath, Anthony Cagle, Eoin T. West, El Antouny G. Neveen, Attwa Mena, Crothers Kristina, and Michael Chung

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Multi-organ dysfunction in Sickle Cell Disease: a rare presentation and its management in resource-limited setting., Fatma Bakshi, Semvua B. Kilonzo, Daniel W. Gunda, and Elichilia R. Shao

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Dasatinib-Induced Chylothorax in Chronic Myeloid Leukemia, Zulfiqar Zulfiqar Qutrio Baloch Qutrio Baloch, Agha Abbas Shabber, Bhatti Hammad, and Sayed Karar