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Submissions from 2023

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Azithromycin for bacterial watery diarrhea: A reanalysis of the antiBiotics for children with severe iarrhea (ABCD) trial incorporating molecular diagnostics, Patricia B. Pavlinac, James Platts-Mills, Jie Liu, Hannah E. Atlas, Jean Gratz, Darwin Operario, Aneeta Hotwani, Furqan Kabir, Farah Qamar, and Mohammad Tahir Yousafzai

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A multicenter observational study on outcomes of moderate and severe pediatric traumatic brain injuries-time to reappraise thresholds for treatment, Syeda Kashfi Qadri, Jan Hau Lee, Yanan Zhu, Paula Caporal, Juan D. Roa G, Sebastián González Dambrauskas, Adriana Yock-Corrales, Qalab Abbas, Yasser Kazzaz, and Luming Shi

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A global systematic review and meta-analysis on the emerging evidence on risk factors, clinical characteristics, and prognosis of multisystem inflammatory syndrome in adults (MIS-A), Mohammad Aadil Qamar, Syed Shabbir Afzal, Rubaid Azhar Dhillon, Mir Ibrahim Sajid, Zouina Sarfraz, Azza Sarfraz, Mehek Narmeen, Omar Irfan, Ivan Cherrez-Ojeda, and Ali Bin Sarwar Zubairi

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Community centred co-design methodology for designing and implementing socio-behavioural interventions to counter COVID-19 related misinformation among marginalized population living in the squatter settlements of Karachi, Pakistan: A methodology paper, Rubina Qasim, Waqas Ahmed Farooqui, Atiya Rahman, Rukhsana Haroon, Madiha Saleem, Muhammad Rafique, Fiza Noor, Afifa Ghani, Muhammad Yaqoob, and Mohammad Tahir Yousafzai

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COHESION: A core outcome set for the treatment of neonatal encephalopathy, Fiona A. Quirke, Shabina Ariff, Malcolm R. Battin, Caitlin Bernard, Linda Biesty, Frank H. Bloomfield, Mandy Daly, Elaine Finucane, Maira Niaz, and Farhana Tabassum

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Challenges and approaches of culturing the unculturable archaea, Muhammad Rafiq, Noor Hassan, Maliha Rehman, Muhammad Hayat, Gullasht Nadeem, Farwa Hassan, Naveed Iqbal, Hazrat Ali, Sahib Zada, and Yingqian Kang

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Life-threatening complication of retropharyngeal abscess in an infant: A case report, Ayaz Ur Rehman, Salman Khan, Awais Abbas, Hamdan Ahmed Pasha, Qalab Abbas, and Naveed ur Rehman Siddiqu

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Immunotherapy for prostate cancer: A current systematic review and patient centric perspectives, Laeeq Ur Rehman, Muhammad Hassan Nisar, Wajeeha Fatima, Azza Sarfraz, Nishwa Azeem, Zouina Sarfraz, and Karla Robles-Velasco

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Addressing the endometriosis knowledge gap for improved clinical care-A cross-sectional pre- and post-educational-intervention study among Pakistani women, Muhammad Saad, Aiman Rafiq, Anam Jamil, Zouina Sarfraz, Azza Sarfraz, Karla Robles-Velasco, and Ivan Cherrez-Ojeda

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Student experiences of simulation-based learning and its impact on their performance in objective structured clinical examination in pediatrics - A mixed method study, sana saeed, Azam Afzal, Farah Khalid, and Fyezah Jehan

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Process evaluation of paediatric fellowship training programs at a university hospital in Pakistan, sana saeed, Prem Chand, Asna Sulaiman, Muhammad Imran Nisar, Khadija N Humayun, Marib Ghulam Rasool Malik, and Fyezah Jehan

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Hybridizing video-based learning with simulation for flipping the clinical skills learning at a university hospital in Pakistan, sana saeed, Maryam Hameed Khan, Muhammad Muneeb Ullah Siddiqui, Anny Dhanwani, Areeba Hussain, and Muhammad Maisam Ali

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Factors associated with medical students' career choices at a private university: a cross-sectional study, sana saeed dr, Mahanoor Raza, Areeba Hussain, Muhammad Maisam Ali, and Farah Khalid

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The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders, Afshin Saffari, Tracy Lau, Homa Tajsharghi, Ehsan Ghayoor Karimiani, Ariana Kariminejad, Stephanie Efthymiou, Giovanni Zifarelli, Tipu Sultan, Mehran Beiraghi Toosi, and Shahnaz Ibrahim

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Two-year duration of immunity of inactivated poliovirus vaccine: A follow-up study in Pakistan in 2020, Ali Faisal Saleem, Sadia Parkar, Syeda Mahjabeen Zehra, Zaubina Kazi, Asma Sadruddin Pethani, Yiting Zhang, Bernardo A. Mainou, Rocio Lopez Cavestany, Grace Macklin, and Visalakshi Jeyaseelan

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Correction: Infant body composition at 6 and 24 months: What are the driving factors?, Ina S. Santos, Caroline S. Costa, Andrew P. Hills, Shabina Ariff, V Pujitha Wickramasinghe, Shane Norris, Alexia J. Murphy-Alford, Christine Slater, Nishani Lucas, and Lukhanyo H. Nyati

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Infant body composition at 6 and 24 months: What are the driving factors?, Ina S. Santos, Caroline S. Costa, Andrew P. Hills, Shabina Ariff, V Pujitha Wickramasinghe, Shane Norris, Alexia J. Murphy-Alford, Christine Slater, Nishani Lucas, and Lukhanyo H. Nyati

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Standard RUTF vs. locally-made RUSF for acutely malnourished children: A quasi-experimental comparison of the impact on growth and compliance in a rural community of Pakistan, Azza Sarfraz, Sheraz Ahmed, Sajid Muhammad, Najeeb Rehman, Sanam Iram Soomro, Abdul Khaliq Qureshi, Sadaf Jakhro, Fayyaz Umrani, Sana Syed, and Syed Asad Ali

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Impact of diarrhoea and acute respiratory infection on environmental enteric dysfunction and growth of malnourished children in Pakistan: A longitudinal cohort study, Azza Sarfraz, Zehra Jamil, Sheraz Ahmed, Fayyaz Umrani, Abdul Khaliq Qureshi, Sadaf Jakhro, Muhammad Sajid, Najeeb Rehman, Arjumand Rizvi, Najeeha Talat Iqbal, Sana Syed, Junaid Iqbal, Kamran Sadiq, and Syed Asad Ali

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Differential coverage for vaccines in the expanded program on immunization (EPI) among children in rural Pakistan, Shahira Shahid, Sheraz Ahmed, Muhammad Farrukh Qazi, Rafey Ali, Syed Asad Ali, Anita K. M. Zaidi, Najeeha Talat Iqbal, Fyezah Jehan, and Muhammad Imran Nisar

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Knowledge, attitudes, and practices towards seasonal influenza vaccination among pregnant women and healthcare workers: A cross-sectional survey in Afghanistan, Shahira Shahid, Shafi Kalhoro, Hajra Khwaja, Mohammad Asif Hussainyar, Junaid Mehmood, Muhammad Farrukh Qazi, Abdinasir Abubakar, Shaza Mohamed, Fyezah Jehan, and Muhammad Imran Nisar

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Inappropriate supplementation of Vitamin D can result in toxicity: A crosssectional study of paediatrics population, Nazia Shamim, Hafsa Majid, Suneeta Khemani, Maliha Salim, Siraj Muneer, and Aysha Habib

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Pulse oximetry: Why oxygen saturation is still not a part of standard pediatric guidelines in low-and-middle-income countries (LMICs), Maheen Sheikh, Huzaifa Ahmad, Romesa Ibrahim, Muhammad Imran Nisar, and Fyezah Jehan

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Determinants of stunting among children under five in Pakistan, Sajid Bashir Soofi, Ahmad Khan, Sumra Kureishy, Imtiaz Hussain, Atif Habib, Muhammad Umer, Shabina Arif, Muhammad Sajid, Arjumand Rizvi, Imran Ahmed, Junaid Iqbal, and Zulfiqar Ahmed Bhutta

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GATA6-AS1 regulates intestinal epithelial mitochondrial functions, and its reduced expression is linked to intestinal inflammation and less favourable disease course in ulcerative colitis, Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Danielle Moshel, Marina BenShoshan, Kelli L. VanDussen, Nina Levhar, Haya Abbas-Egbariya, and Katia Beider

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GATA6-AS1 regulates intestinal epithelial mitochondrial functions, and its reduced expression is linked to intestinal inflammation and less favorable disease course in ulcerative colitis (UC), Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Danielle Moshel, Marina BenShoshan, Kelli L. VanDussen, Nina Levhar, Haya Abbas-Egbariya, Katia Beider, Rakefet Ben-Yishay, and Syed Asad Ali

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Maternal and environmental Impact assessment on neurodevelopment in early childhood years (MINE): A prospective cohort study protocol from a low, middle-income country, Zoya Surani, Sadia Parkar, Gul Afshan, Kinza Naseem Elahi, Zahra Hoodbhoy, Kiran Hilal, and Sidra Kaleem Jafri

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Global pediatric craniopharyngioma management modalities and outcomes, Alan R. Tang, Joseline Haizel-Cobbina, Muhammad Usman Khalid, Uchenna I. Peter-Okaka, Olivia L. Prosak, Naureen Mushtaq, and Michael C. Dewan

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Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan, Kirkby D. Tickell, Donna M. Denno, Ali Faisal Saleem, Zaubina Kazi, Benson O. Singa, Catherine Achieng, Charles Mutinda, Barbra A. Richardson, Kristjana H. Ásbjörnsdóttir, and Stephen E. Hawes

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Promoting science literacy and awareness across the globe: The role of scientists as science ambassadors, Matthew J. Tuttle, Daniela Cejas, Donghoon Kang, Francis Muchaamba, Britta Goncarovs, Yaprak Ozakman, Fatima Aziz, and Arnaud Orelle

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Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: A multinational, observational study, Jose Villar, Constanza P. Soto Conti, Robert B. Gunier, Shabina Ariff, Rachel Craik, Paolo I. Cavoretto, Stephen Rauch, Serena Gandino, Ricardo Nieto, Adele Winsey, and Zulfiqar Ahmed Bhutta

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Efficacy and tolerability of semaglutide in patients with type-2 diabetes mellitus: Experience of a tertiary care hospital, Pakistan, Maria Wajid, Saadia Sattar, Farah Khalid, and Muhammad Qamar Masood

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Pediatric critical care–associated parental traumatic stress: Beyond the first year*, Mekela Whyte-Nesfield, Daniel Kaplan, Peter S. Eldridge, Jiaxiang Gai Gai, William Cuddy, Karli Breeden, Nadia Ansari, Pamela Siller, Jenna M. Mennella, and Toah A. Nkromah

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Pregnant women's experiences with midwifery-led antenatal care services in peri-urban communities in Karachi, Pakistan, Nida Salman Yazdani, Kaniz Amna Haider, Amna Khan, Syed Ali Jaffar Zaidi, Akbar Rajani, Muhammad Imran Nisar, Fyezah Jehan, and Zahra Hoodbhoy

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Safety huddles in paediatric intensive care unit: Implementation and staff perception in a resource limited setting, Arsheen Zeeshan, Yasmin Hashwani, Muhammad Jawwad, Mohammad Tahir Yousafzai, Naveed ur Rehman Siddiqu, and Qalab Abbas

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Impact of COVID-19 on feto-maternal and neonatal health in Karachi, Pakistan, A retrospective cohort study, Mahjabeen Zehra, Sadia Parkar, Zaubina Kazi, Asma Sadruddin Pethani, Ayesha Malik, Adnan Mirza, Falak Abro, Abdul Jabbar, and Ali Faisal Saleem Dr

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Needs assessment for faculty development in health professions education at a medical university in Karachi, Pakistan, Tabassum Zehra, sana saeed, Rahila Ali, Amber Sultan, and Areeba Hussain

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Synthesis, characterization, DPPH radical scavenging, urease enzyme inhibition, molecular docking simulation, and DFT analysis of imine derivatives of 4-formylpyridine with selective detection of Cu+2 Ions, Ambreen Zia, Syed Nawazish Ali, Erum Hasan, Mehreen Lateef, Syeda Rehana Zia, Sana Gul, Syeda Farah Bukhari, and Nazish Dildar

Submissions from 2022

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Unassigned complex unique recombinant forms related to CRF36_cpx in children identified in an HIV-1 outbreak in Pakistan, Syed Hani Abidi, Dilsha Siddiqui, Syed Faisal Mahmood, Amna Rehana Siddiqui, Apsara Ali Nathwani, Aneeta Hotwani, Sharaf Ali Shah, Palwasha Khan, Rashida Abbas Ferrand, and Fatima Mir

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Raoultella species associated sepsis in children: A case series at a tertiary hospital, Karachi, Falak Abro, Asma Sherazi, Sara Fatima, and Ali Faisal Saleem

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Impact of active physiotherapy rehabilitation on pain and global and functional improvement 1-2 months after lumbar disk surgery: A systematic review and meta-analysis, Kiran Afzal, Hafsah Gul Khattak, Abdul Ghafoor Sajjad, Syed Ali Hussain, Zouina Sarfraz, Azza Sarfraz, and Ivan Cherrez-Ojeda

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The correlation of D-dimer to stroke diagnosis within 24 hours: A meta-analysis, Adeel Ahmad, Zara Islam, Saad Manzoor Ahmad, Zouina Sarfraz, Azza Sarfraz, Miguel Felix, and Ivan Cherrez-Ojeda

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A changing epidemic and the rise of opioid-stimulant co-use, Saeed Ahmed, Zouina Sarfraz, and Azza Sarfraz

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Association of anti-rotavirus IgA seroconversion with growth, environmental enteric dysfunction and enteropathogens in rural Pakistani infants, Sheraz Ahmed, Junaid Iqbal, Kamran Sadiq, Fayyaz Umrani, Arjumand Rizvi, Furqan Kabir, Sana Syed, Sajid Muhammad, Aneeta Hotwani, and Najeeb Rehman

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Utility of genetic testing in pediatric epilepsy: Experience from a low to middle-income country, Fizza Akbar, Raisa Saleh, Salman Kirmani, Prem Chand, Khairunnisa Mukhtiar, Farida Jan, Raman Kumar, and Shahnaz Ibrahim

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Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs, Nadia Akseer, Emily Catherine Keats, Pravheen Thurairajah, Simon Cousens, Ana Pilar Bétran, Brietta M. Oaks, David Osrin, Ellen Piwoz, Exnevia Gomo, and Zulfiqar Ahmed Bhutta

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Etiology, clinical characteristics, and outcome of infective endocarditis: 10-year experience from a tertiary care center in Pakistan, Sara Salim Ali, Imran Ahmed Qureshi, Ahmed Ayaz, Ainan Arshad, Awais Farhad, Bushra Jamil, and Muhammad Rizwan Sohail

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Evaluation of pharmaceutically compounded oral caffeine on the impact of medication adherence and risk of readmission among preterm neonates: A single-center quasi-experimental study, Gul Ambreen, Manoj Kumar, Amin Ali, Syed Akbar Ali Shah, Syed Muzaffar Saleem, Ayesha Tahir, Muhammad Sohail Salat, Muhammad Shahzad Aslam, and Kashif Hussain

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Diagnostic accuracy of point-of-care ultrasound compared to standard-of-care methods for endotracheal tube placement in neonates, Shabina Ariff, Khushboo Q. Ali, Mark O. Tessaro, Uzair Ansari, Shaun Morris, Sajid Bashir Soofi, and Hasan S. Merali

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Understanding perceptions and practices for designing an appropriate community-based kangaroo mother care implementation package: Qualitative exploratory study, Shabina Ariff, Ikram Maznani, Maria Asif Bhura, Zahid Memon, Tayyaba Arshad, Tariq Ahmed Samejo, Shujaat Zaidi, Muhammad Umer, Imran Ahmed, Muhammad Atif Habib, Sajid Bashir Soofi, and Zulfiqar Ahmed Bhutta

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Implementation research to increase treatment coverage of possible serious bacterial infections in young infants when a referral is not feasible: lessons learnt, Shabina Ariff, Sajid Bashir Soofi, Zamir Suhag, Suhail Chanar, Maria Asif Bhura, Zaib Dahar, Imran Ahmed, Ali Turab, Atif Habib, Yasir Bin Nisar, and Zulfiqar Ahmed Bhutta

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Homozygous LEPR mutation as a cause of early onset childhood obesity in a Pakistani girl, Muzna Arif, Fozia Memon, Khadija N Humayun, and Salman Kirmani

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Newborn screening for congenital hypothyroidism through dried blood spot in Low middle income country (LMIC): Experience from a tertiary care center, Muzna Arif, Fozia Memon, Khadija N Humayun, and Salman Kirmani

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Role of inhaled antibiotics in children and adolescents with cystic fibrosis: Experience from the tertiary care center, Danish Abdul Aziz, Aiza Abbas, Anusha Alam, and Namrah Aziz

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Association of vitamin D levels and asthma exacerbations in children and adolescents: Experience from a tertiary care center, Danish Abdul Aziz, Aiza Abbas, Werdah Viquar, and Ali Munawar Hussain

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Neurodevelopment and recovery from wasting, Harriet M. Babikako, Celine Bourdon, Emmie Mbale, Peace Aber, Annet Birabwa, Josephine Chimoyo, Wieger Voskuijl, Zaubina Kazi, John Mukisa, and Ali Faisal Saleem

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Risk factors associated with extensively drug-resistant typhoid in an outbreak setting of lyari town Karachi, Pakistan, Rabab Batool, Sonia Qureshi, Mohammad Tahir Yousafzai, Abdul Momin Kazi, Miqdad Ali, and Farah Naz Qamar

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Growth Faltering in Small and Sick Newborn Infants: Does it Matter?, Zulfiqar Ahmed Bhutta

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Optimizing prevention and community-based management of severe malnutrition in children, Zulfiqar Ahmed Bhutta

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Diabetes in Pakistan: Addressing the crisis, Zulfiqar Ahmed Bhutta, Zia Ul Haq, and Abdul Basit

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A healthy future for children and adolescents - Authors' reply, Zulfiqar Ahmed Bhutta, Tyler Vaivada, Maureen M. Black, and Robert E. Black

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Health and development from preconception to 20 years of age and human capital, Robert E. Black, Li Liu, Fernando P. Hartwig, Francisco Villavicencio, Andrea Rodriguez-Martinez, Luis P. Vidaletti, Jamie Perin, Maureen M. Black, Hannah Blencowe, and Zulfiqar Ahmed Bhutta

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Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines, John E. Bowen, Amin Addetia, Ha V Dang, Cameron Stewart, Jack T. Brown, William K. Sharkey, Kaitlin R. Sprouse, Kumail Ahmed, Asefa Shariq Ansari, and Najeeha Talat Iqbal

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SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines, John E. Bowen, Young-Jun Park, Cameron Stewart, Jack T. Brown, William K. Sharkey, Alexandra C. Walls, Anshu Joshi, Kumail Ahmed, Asefa Shariq, and Najeeha Talat Iqbal

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A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease, Elisa Calì, Sheng-Jia Lin, Clarissa Rocca, Yavuz Sahin, Aisha Al Shamsi, Salima El Chehadeh, Myriam Chaabouni, SYNaPS Study Group, Shahnaz Ibrahim, and Salman Kirmani

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Spectrum of common pediatric neurological disorders: A cross-sectional study from three tertiary care centres across Pakistan, Prem Chand, Shahnaz Ibrahim, Khairunnisa Mukhtiar, Safia Awan, Durray Shahwar Abid Khan, Asna Sulaiman, Sajid Muhammad, Zahra Ali Padhani, Jai K. Das, and Mohammad Wasay

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Physician's attitudes on pulmonary rehabilitation following COVID-19: A brief perspective from a developing country, Ivan Cherrez-Ojeda, Emanuel Vanegas, Miguel Felix, María José Farfán Bajaña, Azza Sarfraz, Zouina Sarfraz, Genesis Camacho, Alanna Barrios-Ruiz, and Jack Michel

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Childhood mortality during and after acute illness in Africa and south Asia: A prospective cohort study, Childhood Acute Illness and Nutrition (CHAIN) Network, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Ali Fazal Khan, Ali Faisal Saleem, Benson O. Singa, Blaise Siezanga Gnoumou, Caroline Tigoi, Syed Asad Ali, and Zaubina Kazi

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Performance of machine learning classifiers in classifying stunting among under-five children in Zambia, Obvious Nchimunya Chilyabanyama, Roma Chilengi, Roma Chilengi, Michelo Simuyandi, Caroline C. Chisenga, Masuzyo Chirwa, Kalongo Hamusonde, Rakesh Kumar Saroj, Najeeha Talat Iqbal, and Innocent Ngaruye

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Associations between eight earth observation-derived climate variables and enteropathogen infection: An independent participant data meta-analysis of surveillance studies with broad spectrum nucleic acid diagnostics, Josh M. Colston, Benjamin F. Zaithcik, Hamada S. Badr, Eleanor Burnett, Syed Asad Ali, Ajit Rayamajhi, Syed M. Satter, Daniel Eibach, Ralf Krumkamp, M Imran Nisar, Anita K. M. Zaidi, and Zulfiqar Ahmed Bhutta

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Risk factors for community-acquired bacterial infection among young infants in South Asia: A longitudinal cohort study with nested case–control analysis, Nicholas E. Connor, Mohammad Shahidul Islam, Luke C. Mullany, Nong Shang, Zulfiqar Ahmed Bhutta, Anita K. M. Zaidi, Sajid Bashir Soofi, Muhammad Imran Nisar, Pinaki Panigrahi, and Kalpana Panigrahi

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Alleviating hidden hunger: An infallible bridge to improved health and nutrition, Jai K. Das and Zahra Ali Padhani

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Risk of obstructive sleep apnea and traffic accidents among male bus drivers in Ecuador: Is there a significant relationship?, Miguel Felix, María Belén Intriago Alvarez, Emanuel Vanegas, María José Farfán Bajaña, Zouina Sarfraz, Azza Sarfraz, Jack Michel, and Ivan Cherrez-Ojeda

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Women's health: Optimal nutrition throughout the lifecycle, Edith J M Feskens, Regan Bailey, Zulfiqar Ahmed Bhutta, Hans-Konrad Biesalski, Heather Eicher-Miller, Klaus Krämer, Wen-Harn Pan, and James C. Griffiths

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Newborn weight change and predictors of underweight in the neonatal period in Guinea-Bissau, Nepal, Pakistan and Uganda, Valerie J. Flaherman, Amy S. Ginsburg, Muhammad Imran Nisar, Muddassir Altaf, Khushboo Liaquat, Benazir Baloch, Najeeb Rehman, Yasir Shafiq, Shabina Ariff, and Fyezah Jehan

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Prevalence of hearing loss in children living in low- and middle-income countries over the last 10 years: A systematic review, Hillary V. Ganek, Ada Madubueze, Catherine E. Merritt, and Zulfiqar Ahmed Bhutta

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Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study, Francesca Giuliani, Daniel Oros, Robert B. Gunier, Sonia Deantoni, Stephen Rauch, Roberto Casale, Ricardo Nieto, Enrico Bertino, Albertina Rego, Camilla Menis, and Shabina Ariff

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Burden, clinical characteristics, risk factors, and seasonality of adenovirus 40/41 diarrhea in children in eight low-resource settings, Godfrey Guga, Sarah Elwood, Caroline Kimathi, Gagandeep Kang, Margaret N. Kosek, Aldo A M Lima, Pascal O. Bessong, Amidou Samie, Najeeha Talat Iqbal, and Zulfiqar Ahmed Bhutta

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Measuring contraceptive method mix, prevalence, and demand satisfied by age and marital status in 204 countries and territories, 1970-2019: A systematic analysis for the Global Burden of Disease Study 2019, Annie Haakenstad, Olivia Angelino, Caleb M S Irvine, Zulfiqar Ahmed Bhutta, Kelly Bienhoff, Corinne Bintz, Kate Causey, M Ashworth Dirac, Nancy Fullman, and Emmanuela Gakidou

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Effect of bovine lactoferrin on seroconversion following polio vaccine administration in children: Protocol for a double-blinded randomised controlled trial, Atif Habib, Sidrah Nausheen, Shanila Nooruddin, Tooba Javed, Tariq Samejo, Amjad Hussain, Suneeta Namdave, Sehrish Amirali, Muhammad Umer, and Lumaan Sheikh

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Health workers' experience of a digital health intervention implemented in peri-urban communities in Karachi, Pakistan, Kaniz Amna Haider, Omar Gulam, Rehan Adamjee, Benazir Baloch, and Zahra Hoodbhoy

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Diagnostic accuracy of various immunochromatographic tests for NS1 antigen and IgM antibodies detection in acute dengue virus infection, Mughees Haider, Saira Yousaf, Asifa Zaib, Azza Sarfraz, Zouina Sarfraz, and Ivan Cherrez-Ojeda

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Mental health and positive development prevention interventions: Overview of systematic reviews, Leila Harrison, Naeha Sharma, Omar Irfan, Michele Zaman, Tyler Vaivada, and Zulfiqar Ahmed Bhutta

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A case report on fibular aplasia, tibial campomelia, oligosyndactyly syndrome variant in a male infant, Hina Mumtaz Hashmi, Nazia Shamim, Vinod Kumar, Adnan Mirza, Salman Kirmani, Babar Irfan, and Hania Hasan

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Routine immunization coverage and immunization card retention in Pakistan: Results from a cross-sectional national survey, Imtiaz Hussain, Ahmad Khan, Dale A. Rhoda, Imran Ahmed, Muhammad Umer, Uzair Ansari, Muhammad Akram Shah, Soofia Yunus, Sajid Bashir Soofi, and Zulfiqar Ahmed Bhutta

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Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible, Kashif Hussain, Muhammad Sohail Salat, Shahzad Rauf, Manoj Rathi, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Rahila Ikram, and Gul Ambreen

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Optimal iron content in ready-to-use therapeutic foods for the treatment of severe acute malnutrition in the community settings: A protocol for the systematic review and meta-analysis, Aamer Imdad, Melissa François, Fanny F. Chen, Abigail Smith, Olivia Tsistinas, Emily Tanner Smith, Jai K. Das, and Zulfiqar Ahmed Bhutta

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Enteroinvasive Escherichia Coli O96: H19 is an emergent biofilm-forming pathogen, Junaid Iqbal, Niharika Malviya, Jennifer A. Gaddy, Chengxian Zhang, Andrew J. Seier, Kathryn P. Haley, Ryan S. Doster, Ana E. Farfán-García, and Oscar G. Gómez-Duarte

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Zinc supplementation and the prevention and treatment of sepsis in young infants: A systematic review and meta-analysis, Omar Irfan, Robert E. Black, Zohra S. Lassi, and Zulfiqar Ahmed Bhutta

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Early postoperative arrhythmias after pediatric congenital heart disease surgery: A 5-year audit from a lower- to middle-income country, Sidra Ishaque, Saleem Akhtar, Asma Akbar Ladak, Russell Seth Martins, Muhammad Kamran Younis Memon, Alisha Raza Kazmi, Fatima Mahmood, and Anwar Ul Haque

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Community-based asthma assessment in young children: Adaptations for a multicentre longitudinal study in South Asia, Mohammad Shahidul Islam, Samin Huq, Steven Cunningham, Jurgen Schwarze, ASMD Ashraful Islam, Mashal Amin, Farrukh Raza, Benazir Baloch, Muhammad Imran Nisar, and Sajid Bashir Soofi

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Prevention and management of high-burden noncommunicable diseases in school-age children: A systematic review, Reena P. Jain, Daina Als, Tyler Vaivada, and Zulfiqar Ahmed Bhutta

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Frequency of use and preferences for information and communication technologies in patients with sleep apnea: A multicenter, multinational, observational cross-sectional survey study, Veronica R. Jaritos, Emanuel Vanegas, Juan Facundo Nogueira, Sebastian Leiva Agüero, Vanina Giovini, Jorge Rey de Castro, Yadira Rodríguez Reyes, José Luis Carrillo Alduenda, Pammela Torres Gittaim, Zaira Romero, and Azza Sarfraz

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The WHO global tuberculosis 2021 report - not so good news and turning the tide back to end TB, Chakaya Jeremiah, Eskild Petersen, Rebecca Nantanda, Brenda N. Mungai, Giovanni Battista Migliori, Farhana Amanullah, Patrick Lungu, Francine Ntoumi, and Nagalingeswaran Kumarasamy

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Compounding inequalities: Adolescent psychosocial wellbeing and resilience among refugee and host communities in jordan during the COVID-19 pandemic, Nicola Jones, Sarah Baird, Bassam Abu Hamad, Zulfiqar Ahmed Bhutta, Erin Oakley, Manisha Shah, Jude Sajdi, and Kathryn M. Yount

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COVID-19, nutrition, and gender: An evidence-informed approach to gender-responsive policies and programs, Anna Kalbarczyk, Noora-Lisa Aberman, Bregje S M van Asperen, Rosemary Morgan, Zulfiqar Ahmed Bhutta, Bianca Carducci, Rebecca Heidkamp, Saskia Osendarp, Neha Kumar, and Anna Lartey

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Exploring terminology for puerperal sepsis and its symptoms in urban Karachi, Pakistan to improve communication, care-seeking, and illness recognition, Anna Kalbarczyk, Fatima Mir, Shabina Ariff, Aspara Ali, Abdul Momin Kazi, Gurpreet Kaur, Farheen Yousuf, Farzeen Hirani, Shazia Sultana, Linda A. Bartlett, Amnesty E. Lefevre, and Sajid Bashir Soofi

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Acute stress in parents of patients admitted to the pediatric intensive care unit: A two-center cross-sectional observational study, Daniel Kaplan, Mekela Whyte Nesfield, Peter S. Eldridge, WIlliam Cuddy, Nadia Ansari, Pamela Siller, and Simon Li

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Malaria reduction drove childhood stunting decline in Uganda: A mixed-methods country case study, Emily C. Keats, Richard B. Kajjura, Anushka Ataullahjan, Muhammad Islam, Breagh Cheng, Ahalya Somaskandan, Kimberly D. Charbonneau, Erica Confreda, Rachel Jardine, and Zulfiqar A. Bhutta

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Knowledge and Practices on the Prevention and management of diarrhea in children under-2 years among women dwelling in urban slums of Karachi, Pakistan, Asif Khaliq, Amreen 1, Nazia Jameel, and Stefanie J. Krauth