Mirror image or molecular mirage? Investigating hormone receptor disconcordance in breast cancer brain metastases
Document Type
Article
Department
Neurosurgery
Abstract
Breast cancer brain metastases (BCBM) are a significant clinical challenge, especially in aggressive subtypes like HER2-positive and triple-negative breast cancer. This review discusses hormone receptor discordance, it's existence and contributing factors, the role of the bloodbrain barrier (BBB) in metastatic progression, and therapeutic modalities. While local treatments such as surgery and radiotherapy remain foundational, advances in systemic and immunotherapeutic approaches show promising potential. A deeper understanding of molecular mechanisms driving BCBM is essential to guide effective treatments and improve patient outcomes.
Publication (Name of Journal)
Journal of the Pakistan Medical Association
DOI
10.47391/JPMA.25-65
Recommended Citation
Tariq, Q.,
Ali, E. A.,
Ahmad, N.,
Anis, S.,
Yousaf, I.,
Shamim, M.
(2025). Mirror image or molecular mirage? Investigating hormone receptor disconcordance in breast cancer brain metastases. Journal of the Pakistan Medical Association, 75(8), 1304-1306.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_surg_neurosurg/420