Bridging radiology and pathology: ATRX Loss and T2-FLAIR mismatch as early diagnostic and prognostic markers in diffuse gliomas
Document Type
Review Article
Department
Surgery
Abstract
ATRX mutation and the T2-FLAIR mismatch sign have emerged as complementary molecular and imaging markers in diffuse gliomas. ATRX loss defines IDH-mutant astrocytoma at the molecular level, while the mismatch sign provides a non-invasive radiological clue with high specificity but limited sensitivity. Used together, they improve diagnostic precision, refine prognostic assessment, and guide individualized treatment planning.
AKU Student
no
Publication (Name of Journal)
Journal of the Pakistan Medical Association
DOI
10.47391/JPMA.25-106
Recommended Citation
Tariq, Q.,
Ali, E. A.,
Arshad, R.,
Sohail, A.,
Yousaf, I.,
Shamim, M. S.
(2025). Bridging radiology and pathology: ATRX Loss and T2-FLAIR mismatch as early diagnostic and prognostic markers in diffuse gliomas. Journal of the Pakistan Medical Association, 75(12), 1986-1989.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_surg_neurosurg/425