Clinical outcomes and quality of life after endovascular embolization for vein of Galen aneurysmal malformation (VGAM): A study from a low-and middle-income country

Document Type

Article

Department

Neurosurgery; Radiology

Abstract

Objective: Vein of Galen aneurysmal malformations (VGAMs) represent the very epitome of challenge in pediatric neurosurgery. Despite the widespread acceptance of embolization for its treatment, due to the rarity of disease occurrence, its long-term outcomes and impact on the quality of life is not well-established. The study evaluates the long-term clinical outcomes and quality of life in patients undergoing endovascular embolization for VGAMs.
Methods: This is a retrospective review on a cohort of patients with VGAM who underwent endovascular embolization at our center between 2000 and 2022. Patients having aneurysm without true malformation, having dural/pial arteriovenous fistulas, who underwent any cycle of angioembolization from another center, or loss to follow-up were excluded. King's Outcome Scale for Childhood Injury (KOSCHI)/Extended Glasgow Outcome Score (GOSE) was used to evaluate the long-term neurological outcomes. Patients were classified into three groups: good outcome (KOSCHI = 5-4b), poor outcome (KOSCHI = 4a-2), and deceased. Eight items from the Rivermead Post-concussion Symptoms Questionnaire were used to evaluate the quality of life.|
Results: Twelve patients with VGAM underwent angioembolization. The majority were children (66.7%), followed by adults (25%) and neonates (8.3%). The most common VGAM type was mural (58.3%), followed by choroidal (25%) and mixed (16.6%). Near-complete or complete occlusion was achieved in 91.6% of cases. Long-term neurological outcomes, assessed using the KOSCHI/GOSE score, showed that 50% had good outcomes (4B-5A), while 25% had poor outcomes (4A), and 25% were deceased. Fisher's exact test revealed a significant association between the staged embolization and KOSCHI score (p = 0.018); however, Spearman's correlation suggested a weak, non-significant trend (a greater number of stages have higher KOSCHI/GOSE, p = 0.085), indicating possible confounding factors.
Conclusion: The long-term neurological outcomes of VGAM embolization remain variable. While staged embolization was significantly associated with outcomes, other factors may contribute. Larger studies are needed to determine the optimal approach for embolization to improve outcomes.

Comments

Pagination is not provided by the author/publisher.

Publication (Name of Journal)

Child's Nervous System

DOI

10.1007/s00381-025-06882-6

Link to Full Text

Share

COinS