The Department of Pathology and Laboratory Medicine at the Aga Khan University, Nairobi Campus is deeply committed to providing excellence in teaching and training residents in the disciplines of anatomical and clinical pathology, basic and translational research, scholarship and diagnostic services of the highest standard in the region. We boast a team of highly trained and skilled technical personnel and 15 expert-specialist faculty involved in collaborative and multidisciplinary research

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Submissions from 2009

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Early outcome of three cases of melanotic neuroectodermal tumour of infancy, F. M. A. Butt, S. W. Guthua, M. L. Chindia, and F. Rana

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Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas: a comparison between Italian and African samples, Alessandro Carugi, Anna Onnis, Giuseppina Antonicelli, Benedetta Rossi, Susanna Mannucci, Anna Luzzi, Stefano Lazzi, Cristiana Cristiana Bellan, Gian Marco Tosi, Shahin Sayed, Giulia De Falco, and Lorenzo Leoncini

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Cancer of the penis: case report, D. K. Kiptoon, P. M. Ngugi, and F. S. Rana

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Utility of free to total PSA ratio in the prediction of prostate cancer in patients with intermediate total PSA levels and negative digital rectal examination, Muthoni .J .F. Kirimi

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Rare lymphoid neoplasms coexpressing B- and T-cell antigens. The role of PAX-5 gene methylation in their pathogenesis, Stefano Lazzi, Cristiana Bellan, Anna Onnis, Giulia De Falco, Shahin Sayed, Ioannis Kostopoulos, Monica Onorati, Alessandro D'Amuri, Rosa Santopietro, and Carla Vindigni

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Prevalence of gastric mucosal interleukin-1 polymorphisms in Kenyan patients with advanced gastric cancer, Kimang’a Nyerere, Shahin Sayed, Gunturu Revathi, Peter Ojwang, Viviene Matiru, Smita Devani, Mahesh Shah, and Samuel Kariuki

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Median values for second-trimester maternal serum αlpha fetoprotein and human chorionic gonadotrophin (double test) at Aga Khan University Hospital-Nairobi, Nancy A. Okinda

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Coartem°: The journey to the clinic, Zul Premji

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Chlorproguanil - Dapsone - Artesunate versus artemether - Lumefantrine: A randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria, Zul Premji, R.E. Umeh, S. Owusu-Agyei, F. Esamai, E.U. Ezedinachi, S. Oguche, S. Borrmann, A. Sowunmi, S. Duparc, P.L. Kirby, A. Pamba, L. Kellam, R. Guiguemde, B. Greenwood, S.A. Ward, and P.A. Winstanley

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The influence of antiretroviral therapy on QTc interval amongst HIV patients at Aga Khan University Hospital, Nairobi, Jay Shavadia

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Disseminated cryptococcosis, an unusual cause of gross proteinuria in an HIV-infected patient, Jay Shavadia, Shahin Sayed, R Gunturu, Ahmed Sokwala, and Mohamed Said Abdullah

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Factors influencing adherence to referral advice following pre-referral treatment with artesunate suppositories in children in rural Tanzania, Daudi Simba, Marian Warsame, Omari Kimbute, Deodatus Kakoko, Max Petzold, Goran Tomson, Zul Premji, and Melba Gomes

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In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa, C. Sisowath, I. Petersen, M.I. Veiga, A. Martensson, Zul Premji, A. Bjorkman, D.A. Fidock, and J.P. Gil

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A comparative study of the genotype MTBDRplus® assay against a standard culture method for diagnosis and drug susceptibility testing of tuberculosis, Peris W. Thamaini

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External quality assurance of breast cancer pathologic reporting in Kenya, ME Trinkaus, Shahin Sayed, Samuel Gakinya, W Hanna, Zahir Moloo, and Y Rahim

Submissions from 2008

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Conclusions and recommendations of a who expert consultation meeting on iron supplementation for infants and young children in malaria endemic areas [Conclusions et recommandations à l'issue de la consultation de l'oms sur la lutte contre la carence martiale chez le nourrisson et le jeune enfant dans les pays d'endémie palustre], L. Allen, R.E. Black, N. Brandes, G. Brittenham, G. Chazot, C Chunming, J. Crawley, B. De Benoist, N. Dalmiya, I. Darnton-Hill, K. Dewey, S. El-Arifeen, O. Fontaine, C. Geissler, H. Haberle, P. Harvey, J. Hasler, C. Hershko, R. Hurrell, M.A. Juma, B. Lonnerdal, B. Lozoff, S. Lynch, H. Martines Salgado, E. McLean, J. Metz, S. Oppenheimer, Zul Premji, A. Prentice, M. Ramsan, C. Ratledge, R. Stoltzfus, and J. Tielsch

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Primary cerebral angitis of the central nervous system: case report, S. Das, J. O. Jowi, K. Hameed, and F. S. Rana

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Pathological sub-types, risk factors and outcome of stroke at the Nairobi hospital, Kenya, James Jowi and Peter Mativo

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Causes, magnitude and management of burns in under-fives in district hospitals in Dar es Salaam, Tanzania., M. Justin-Temu, G. Rimoy, Zul Premji, and G. Matemu

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Genetic analysis of HIV-1 subtypes in Nairobi, Kenya, Suhail Khoja, Peter Ojwang, Saeed Khan, Nancy Okinda, Reena Harania, and Syed Ali

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Impact of training in clinical and microscopy diagnosis of childhood malaria on antimalarial drug prescription and health outcome at primary health care level in Tanzania: A randomized controlled trial, B. Ngasala, M. Mubi, M. Warsame, M.G. Petzold, A.Y. Massele, L.L. Gustafsson, G. Tomson, Zul Premji, and A. Bjorkman

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Laparoscopic management of an ovarian ectopic pregnancy: case report, Y. Patel, Sikolia Wanyonyi, and F. S. Rana

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The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: A review of the evidence, Zul Premji, S. Abdulla, B. Ogutu, A. Ndong, C.O. Falade, I. Sagara, N. Mulure, O. Nwaiwu, and G. Kokwaro

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Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial, Abdulla S., Sagara I., Borrmann S., D'Alessandro U., González R., M. Hamel, Bernhards Ogutu, A. Mårtensson, J. Lyimo, H. Maiga, P. Sasi, Alain Nahum, Quique Bassat, E. Juma, and Zul Premji

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Willingness and ability to pay for artemisinin-based combination therapy in rural Tanzania, E.C. Saulo, B.C. Forsberg, Zul Premji, S.M. Montgomery, and A. Bjorkman

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Utility of liver biopsy in HIV-infected patients presenting with febrile illnesses and inconclusive evaluation, J. Shavadia, Sitna Mwanzi, F. Rana, and Majid Twahir

Submissions from 2007

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Erratum to "Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania" [Mol. Biochem. Parasitol. 149 (2006) 208-215] (DOI:10.1016/j.molbiopara.2007.01.007), A.K. Bei, C.D. Membi, J.C. Rayner, M. Mubi, B. Ngasala, A.A. Sultan, Zul Premji, and M.T. Duraisingh

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Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania, A.K. Bei, C.D. Membi, J.C. Rayner, M. Mubi, B. Ngasala, A.A. Sultan, Zul Premji, and M.T. Duraisingh

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Cheilitis glandularis progressing to squamous cell carcinoma in an HIV-infected patient: case report, F. M. A. Butt, M. L. Chindia, F. S. Rana, and A. Ashani

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Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania, Andreas Martensson, Johan Ursing, M. Isabel Veiga, Lisa Wiklund, Christopher Membi, Scott M. Montgomery, Zul Premji, Anna Farnert, Andres Bjorkman, and Billy Ngasala

Submissions from 2006

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Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes, Elisabeth Hugosson, Scott M. Montgomery, Zul Premji, Marita Troye-Blomberg, and Anders Bjorkman

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Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: A pooled analysis of individual patient data, M. Makanga, Zul Premji, C. Falade, J. Karbwang, E.A. Mueller, K. Andriano, P. Hunt, and P.I. De Palacios

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Embryonal rhabdomyosarcoma with uterine inversion: case report, SBO Ojwang, F Rana, Shahin Sayed, and WK ARUASA

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Bronchoscopic study on aetiology of chronic cough in HIV-infected adults with negative sputum smears for Mycobacterium tuberculosis at Kenyatta National Hospital, Nairobi, A. M. Siika, J. M. Chakaya, Gunturu Revathi, S. S. Mohamed, and K.M .. Bhatt

Submissions from 2005

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Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malaria, C. Duggan, W.B. MacLeod, N.F. Krebs, J.L. Westcott, W.W. Fawzi, Zul Premji, V. Mwanakasale, J.L. Simon, K. Yeboah-Antwi, and D.H. Hamer

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Efficacy and safety of artemether-lumefantrine (Coartem®) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria, C. Falade, M. Makanga, Zul Premji, C.E. Ortmann, M. Stockmeyer, and P. Ibarra de Palacios

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The pervasive triad of food security, gender inequity and women's health: Exploratory research from sub-Saharan Africa, A.A. Hyder, S. Maman, J.E. Nyoni, S.A. Khasiani, N. Teoh, Zul Premji, and S. Sohani

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Increasing prevalence of multidrug-resistant non-typhoidal salmonellae, Kenya, 1994–2003, Samuel Kariuki, Gunturu Revathi, Nyambura Kariuki, Jane Muyodi, Joyce Mwituria, Agnes Munyalo, Dorothy Kagendo, Lawrence Murungi, and Anthony C. Hart

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Bacterial isolates in severely malnourished children at Kenyatta National Hospital, Nairobi, N. Noorani, William Macharia, D. Oyatsi, and Gunturu Revathi

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Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period, M.A. Sattler, D. Mtasiwa, M. Kiama, Zul Premji, M. Tanner, G.F. Killeen, and C. Lengeler

Submissions from 2004

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Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: Double-blind randomised controlled trial, A. Alloueche, W. Bailey, S. Barton, J. Bwika, P. Chimpeni, C.O. Falade, F.A. Fehintola, J. Horton, S. Jaffar, T. Kanyok, P.G. Kremsner, J.G. Kublin, T. Lang, M.A. Missinou, and Zul Premji

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Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites, S.J. Bates, P.A. Winstanley, W.M. Watkins, A. Alloueche, J. Bwika, T.C. Happi, P.G. Kremsner, J.G. Kublin, Zul Premji, and C.H. Sibley

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Higher IL-10 levels are associated with less effective clearance of Plasmodium falciparum parasites, E. Hugosson, S.M. Montgomery, Zul Premji, M. Troye-Blomberg, and A. Bjorkman

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Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance, K. Mugittu, M. Ndejembi, A. Malisa, M. Lemnge, Zul Premji, A. Mwita, W. Nkya, J. Kataraihya, S. Abdulla, H.-P. Beck, and H. Mshinda

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Averting a malaria disaster in Africa - Where does the buck stop?, C.J.M. Whitty, R. Allan, V. Wiseman, S. Ochola, M.V. Nakyanzi-Mugisha, B. Vonhm, M. Mwita, C. Miaka, A. Oloo, Zul Premji, C. Burgess, and T.K. Mutabingwa

Submissions from 2003

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Age, temperature, and parasitaemia predict chloroquine treatment failure and anaemia in children with uncomplicated Plasmodium falciparum malaria, D.H. Hamer, W.B. MacLeod, E. Addo-Yobo, C.P Duggan, B. Estrella, W.W. Fawzi, J.K. Konde-Lule, V. Mwanakasale, Zul Premji, F. Sempertegui, F.P. Ssengooba, K. Yeboah-Antwi, and J.L. Simon

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Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria, E. Hugosson, D. Tarimo, M. Troye-Blomberg, S.M. Montgomery, Zul Premji, and A. Bjorkman

Submissions from 2002

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Acridine Orange for malaria diagnosis: Its diagnostic performance, its promotion and implementation in Tanzania, and the implications for malaria control, J. Keiser, J. Utzinger, Zul Premji, Y. Yamagata, and B.H. Singer

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A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by chloroquine treatment in Tanzania, A.G. Schneider, Zul Premji, I. Felger, T. Smith, S. Abdulla, H.-P. Beck, and H. Mshinda

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Effect of zinc on the treatment of Plasmodium falciparum malaria in children: A randomized controlled trial, F. Sempertegui, B. Estrella, F.R. Toapanta, D.S. Torres, D.E. Calahorrano, K. Yeboah-Antwi, E. Addo-Yobo, P. Arthur, S. Newton, Zul Premji, M. Hubert, C.S. Makwaya, F. Ssengooba, J. Konde-Lule, E. Mukisa, D.H. Hamer, W. MacLeod, C. Duggan, W. Fawzi, J. Simon, V. Mwanakasale, M. Mulenga, T. Sukwa, and J. Tshiula

Submissions from 2001

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An analysis of anemia and child mortality, B.J. Brabin, Zul Premji, and F. Verhoeff

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Acute haemolysis in childhood falciparum malaria, H. Ekvall, P. Arese, F. Turrini, K. Ayi, F. Mannu, Zul Premji, and A. Bjorkman

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Hemoglobin concentration in children in a malaria holoendemic area is determined by cumulated Plasmodium falciparum parasite densities, H. Ekvall, Zul Premji, S. Bennett, and A. Bjorkman

Submissions from 2000

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Micronutrient and iron supplementation and effective anti-malarial treatment synergistically improve childhood anaemia, H. Ekvall, Zul Premji, and A. Bjorkman

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Acute adenolymphangitis due to bancroftian filariasis in Rufiji district, south east Tanzania, D.B. Gasarasi, Zul Premji, P.G.M. Mujinja, and R. Mpembeni

Submissions from 1999

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Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania, Zul Premji, C. Makwaya, and J.N. Minjas

The use of permethrin-impregnated bednets for malaria control in coastal Tanzania: Preliminary entomological impact on vectors, E.A. Temu, J.N. Minjas, Z. Premji, R.H. Hunt, and C.J. Shiff

Submissions from 1998

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Chloroquine treatment for uncomplicated childhood malaria in an area with drug resistance: Early treatment failure aggravates anaemia, H. Ekvall, Zul Premji, and A. Bjorkman

Submissions from 1997

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Mosques against malaria, M.S. Mfaume, P.J. Winch, A.M. Makemba, and Zul Premji

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Community based studies on childhood mortality in a malaria holoendemic area on the Tanzanian coast, Zul Premji, P. Ndayanga, C. Shiff, J. Minjas, P. Lubega, and J. MacLeod

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Social and cultural factors affecting rates of regular retreatment of mosquito nets with insecticide in Bagamoyo District, Tanzania, P.J. Winch, A.M. Makemba, V.R. Makame, M.S. Mfaume, M.C. Lynch, Zul Premji, J.N. Minjas, and C.J. Shiff

Submissions from 1996

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Treatment practices for degedege, a locally recognized febrile illness, and implications for strategies to decrease mortality from severe malaria in Bagamoyo District, Tanzania, A.M. Makemba, P.J. Winch, V.M. Makame, G.L. Mehl, Zul Premji, J.N. Minjas, and C.J. Shiff

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Changes in weight gain and anaemia attributable to malaria in Tanzanian children living under holoendemic conditions, C. Shiff, W. Checkley, P. Winch, Zul Premji, J. Minjas, and P. Lubega

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Local terminology for febrile illnesses in Bagamoyo District, Tanzania and its impact on the design of a community-based malaria control programme, P.J. Winch, A.M. Makemba, S.R. Kamazima, M. Lurie, G.K. Lwihula, Zul Premji, J.N. Minjas, and C.J. Shiff

Submissions from 1995

Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium falciparum malaria and in vitro susceptibility to artemisinin, chloroquine, and mefloquine, M.H. Alin, C.M. Kihamia, A. Bjorkman, B.A. Bwijo, Z. Premji, G.J.B. Mtey, and M. Ashton

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Anaemia and Plasmodium falciparum infections among young children in an holoendemic area, Bagamoyo, Tanzania, Zul Premji, Y. Hamisi, C. Shiff, J. Minjas, P. Lubega, and C. Makwaya

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Changes in malaria associated morbidity in children using insecticide treated mosquito nets in the Bagamoyo District of Coastal Tanzania, Zul Premji, P. Lubega, Y. Hamisi, E. Mchopa, J. Minjus, W. Checkley, and C. Shiff

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Insecticide-treated bed nets in control of malaria in Africa, C. Shiff, Zul Premji, and J. Minjas

Submissions from 1994

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Chloroquine resistant Plasmodium falciparum in coastal Tanzania. A challenge to the continued strategy of village based chemotherapy for malaria control, Zul Premji, J.N. Minjas, and C.J. Shiff

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Laboratory diagnosis of malaria by village health workers using the rapid manual ParaSight™-F test, Zul Premji, J.N. Minjas, and C.J. Shiff

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The PoroSightR-F test: A simple rapid manual dipstick test to detect Plasmodium falciparum infection, C.J. Shiff, J. Minjas, and Zul Premji

Submissions from 1993

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The rapid manual ParaSight®-F test. A new diagnostic tool for Plasmodium falciparum infection, C.J. Shiff, Zul Premji, and J.N. Minjas

Submissions from 1990

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Standard and reduced doses of sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum in Tanzania, with determination of drug concentrations and susceptibility in vitro, U. Hellgren, C.M. Kihamia, Y. Bergqvist, M. Lebbad, Zul Premji, and L. Rombo

Submissions from 1989

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Local anaesthetic cream for the alleviation of pain during venepuncture in Tanzanian schoolchidren, U. Hellgren, C.M. Kihamia, Zul Premji, and K. Danielson