Document Type
Article
Department
Pathology (East Africa)
Abstract
Patient data from eight clinical trials were pooled and analyzed to study the efficacy and safety of the six-dose versus four-dose regimen of artemether-lumefantrine (coartemether; Coartem) in children weighing 5-25 kg. A total of 544 patients with uncomplicated P. falciparum malaria (six-dose: 343; four-dose: 201), matched for demographic and baseline characteristics and individual coartemether doses were included in the analysis. Analysis of day 28 cure rate based on the intention-to-treat and evaluable populations yielded corrected cure rates for the six-dose regimen of 93% and 96% compared with 61% and 76%, respectively, for the four-dose regimen (P < 0.0001 for both comparisons). Similarly high cure rates were achieved with the six-dose regimen in non-immune infants weighing as little as 5 kg. The six- and four-dose regimens were equally well tolerated. The main finding of this analysis is that the six-dose regimen of coartemether is safe and more efficacious than the four-dose regimen in children. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Publication (Name of Journal)
American Journal of Tropical Medicine and Hygiene
Recommended Citation
Makanga, M.,
Premji, Z.,
Falade, C.,
Karbwang, J.,
Mueller, E.,
Andriano, K.,
Hunt, P.,
De Palacios, P.
(2006). Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: A pooled analysis of individual patient data. American Journal of Tropical Medicine and Hygiene, 74(6), 991-998.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_pathol/72
Comments
This work was published prior to author’s joining Aga Khan University