Mental health concerns are now at the top of the list of threats to the economic and social well-being of the people and communities served by AKU. Children and youth, a huge demographic in served countries, are especially vulnerable with large proportions of the population already suffering the lifelong consequences of inaction.​
​The Brain and Mind Institute is a new entity that operates across the Aga Khan University’s multi-country campuses, connecting the rich tapestry of academic entities, and facilitating interdisciplinary research, education and related clinical programming in mental health and neurosciences. The Institute is developing an integrated mental health framework and its work program involves Read more...

Follow

Submissions from 2002

Link

Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains., Rick S. Shin, Hymie Anisman, Dan C. McIntyre, and Zul Merali

Submissions from 2001

Link

Posttraumatic stress symptoms and salivary cortisol levels, Hymie Anisman, Jenna Griffiths, Kimberly Matheson, Arun V. Ravindran, and Zul Merali

Link

Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: mouse strain-dependent outcomes, Hymie Anisman, Shawn Hayley, Kelly Owen, Thomas Borowski, and Zul Merali

Link

Rodent Models of Depression: Learned Helplessness Induced in Mice, Hymie Anisman, Zul Merali, K Brennan, and D Roberts

Link

Central monoamine activity in genetically distinct strains of mice following a psychogenic stressor: effects of predator exposure, Shawn Hayley, Thomas Borowski, Zul Merali, and Hymie Anisman

Link

Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects, Shawn Hayley, Susan Lacosta, Zul Merali, Nico Van Rooijen, and Hymie Anisman

Link

Time-dependent sensitization of corticotropin-releasing hormone, arginine vasopressin and c-fos immunoreactivity within the mouse brain in response to tumor necrosis factor-α, Shawn Hayley, William Staines, Zul Merali, and Hymie Anisman

Link

Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin, P Kent, Hymie Anisman, and Zul Merali

Link

Bombesin-induced HPA and sympathetic activation requires CRH receptors, P Kent, Tania Bédard, Samir Khan, Hymie Anisman, and Zul Merali

Link

Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat., Zul Merali, Pam Kent, David Michaud, Dan McIntyre, and Hymie Anisman

Submissions from 2000

Link

Acoustic startle and fear-potentiated startle in rats selectively bred for fast and slow kindling rates: relation to monoamine activity., Hymie Anisman, Kelly Owen, Shawn Hayley, Thomas Borowski, Zul Merali, and Dan C. McIntyre

Link

Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations, Karen Brebner, Shawn Hayley, Robert Zacharko, Zul Merali, and Hymie Anisman

Link

Dysthymia: a review of pharmacological and behavioral factors, J Griffiths, AV Ravindran, Zul Merali, and Hymie Anisman

Link

A prospective study of neuroendocrine and immune alterations associated with the stress of an oral academic examination among graduate students, K Lacey, M.D Zaharia, J Griffiths, A.V Ravindran, Zul Merali, and Hymie Anisman

Link

Central Monoamine Activity following Acute and Repeated Systemic Interleukin-2 Administration, Susan Lacosta, Zul Merali, and Hymie Anisman

Link

Neither acute nor chronic exposure to a naturalistic (predator) stressor influences the interleukin-1beta system, tumor necrosis factor-alpha, transforming growth factor-beta1, and neuropeptide mRNAs in specific brain regions, Carlos R. Plata-Salamán, Sergey E. Ilyin, Nicolas P. Turrin, Dave Gayle, Mark C. Flynn, Tanya Bedard, Zul Merali, and Hymie Anisman

Link

Lymphocyte proliferation among major depressive and dysthymic patients with typical or atypical features, Marilee D. Zaharia, Arun V. Ravindran, Jenna Griffiths, Zul Merali, and Hymie Anisman

Submissions from 1999

Link

Anhedonic and anxiogenic effects of cytokine exposure, Hymie Anisman and Zul Merali

Link

Understanding stress: characteristics and caveats, Hymie Anisman and Zul Merali

Link

Interleukin-1 beta production in dysthymia before and after pharmacotherapy, Hymie Anisman, Arun V. Ravindran, Jenna Griffiths, and Zul Merali

Link

Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features, Hymie Anisman, A.V Ravindran, Jenna Griffiths, and Zul Merali

Link

Interleukin-1 beta production in dysthymia before and after pharmacotherapy, Hymie Anisman, A.V Ravindran, Jenna Griffiths, and Zul Merali

Link

Influence of bombesin on threshold for feeding and reward in the rat, T Bushnik, C Bielajew, A T. Konkle, and Zul Merali

Link

Stressor-induced alterations in serotonergic activity in an animal model of depression, Thomas J. Connor, Cai Song, Brian E. Leonard, Hymie Anisman, and Zul Merali

Link

Anatomical basis for pressure on the common peroneal nerve, Amadi O. Ihunwo and N. D. Dimitrov

Link

Effects of acute restraint stress on endogenous adrenomedullin levels, S Khan, D Michaud, T W. Moody, Hymie Anisman, and Zul Merali

Link

Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxiogenic-like effects, Susan Lacosta, Zul Merali, and Hymie Anisman

Link

Influence of acute and repeated interleukin-2 administration on spatial learning, locomotor activity, exploratory behaviors, and anxiety, Susan Lacosta, Zul Merali, and Hymie Anisman

Link

Influence of Psychosocial, Psychogenic and Neurogenic Stressors on Several Aspects of Immune Functioning in Mice, Zheng Wu Lu, Shawn Hayley, Arun V. Ravindran, Zul Merali, and Hymie Anisman

Link

Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats, Dan C. McIntyre, Pam Kent, Shawn Hayley, Zul Merali, and Hymie Anisman

Link

Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects, Judy Mclntosh, Hymie Anisman, and Zul Merali

Link

The role of bombesin and bombesin-related peptides in the short-term control of food intake, Zul Merali, Judy Mclntosh, and Hymie Anisman

Link

Hypertrophic cardiomyopathy: Case report, A. U. Mukhtar and Amadi O. Ihunwo

Link

Treatment of primary dysthymia with group cognitive therapy and pharmacotherapy: clinical symptoms and functional impairments, Arun V. Ravindran, Hymie Anisman, Zul Merali, Yoland Charbonneau, John Telner, Robert J. Bialik, Andrew Wiens, Jack Ellis, and Jenna Griffiths

Link

Circulating lymphocyte subsets in obsessive compulsive disorder, major depression and normal controls, Arun V. Ravindran, Jenna Griffiths, Zul Merali, and Hymie Anisman

Link

Influence of acute tryptophan depletion on mood and immune measures in healthy males, Arun V. Ravindran, Jenna Griffiths, Zul Merali, V J. Knott, and Hymie Anisman

Submissions from 1998

Link

Neural plasticity, neuropeptides and anxiety in animals--implications for understanding and treating affective disorder following traumatic stress in humans, R Adamec, Pam Kent, Hymie Anisman, T Shallow, and Zul Merali

Link

Differential effects of interleukin (IL)-1β, IL-2 and IL-6 on responding for rewarding lateral hypothalamic stimulation, Hymie Anisman, L Kokkinidis, Thomas Borowski, and Zul Merali

Link

Stressor-induced corticotropin-releasing hormone, bombesin, ACTH and corticosterone variations in strains of mice differentially responsive to stressors., Hymie Anisman, Susan Lacosta, Pamela Kent, Dan C. McIntyre, and Mohamoud Merali

Link

Do early-life events permanently alter behavioral and hormonal responses to stressors?, Hymie Anisman, Marilee D. Zaharia, Michael J. Meaney, and Zul Merali

Link

Lipopolysaccharide, central in vivo biogenic amine variations, and anhedonia, Thomas Borowski, Larry Kokkinidis, Zul Merali, and Hymie Anisman

Link

An assessment of the effects of central interleukin-1beta, -2, -6, and tumor necrosis factor-alpha administration on some behavioural, neurochemical, endocrine and immune parameters in the rat., Thomas J. Connor, Cai Song, Brian E. Leonard, Zul Merali, and Hymie Anisman

Link

Influence of interleukin-1beta on exploratory behaviors, plasma ACTH, corticosterone, and central biogenic amines in mice., Susan Lacosta, Zul Merali, and Hymie Anisman

Link

Influence of a Psychogenic and a Neurogenic Stressor on Several Indices of Immune Functioning in Different Strains of Mice, Z W. Lu, Cai Song, A V. Ravindran, Zul Merali, and Hymie Anisman

Link

Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala, Zul Merali, Judy Mclntosh, Pam Kent, David Michaud, and Hymie Anisman

Link

Sustained bombesin exposure results in receptor down-regulation and tolerance to the chronic but not acute effects of bombesin on ingestion, Hélène Plamondon, Carole Lambert, and Zul Merali

Link

Circulating lymphocyte subsets in major depression and dysthymia with typical or atypical features, Arun V. Ravindran, Jenna Griffiths, Zul Merali, and Hymie Anisman

Submissions from 1997

Link

Influence of Psychogenic and Neurogenic Stressors on Endocrine and Immune Activity: Differential Effects in Fast and Slow Seizing Rat Strains, Hymie Anisman, Z W. Lu, Cai Song, Pamela Kent, D. C. Mcintyre, and Zul Merali

Link

Chronic stressors and depression: distinguishing characteristics and individual profiles, Hymie Anisman and Zul Merali

Link

Neuroendocrine measures and lymphocyte subsets in depressive illness: influence of a clinical interview concerning life experiences, Jenna Griffiths, Arun V. Ravindran, Zul Merali, and Hymie Anisman

Link

Distribution of median nerve to muscles of the anterior compartment of the arm., Amadi O. Ihunwo, S. P. Osinde, and A. U. Mukhtar

Link

ARE BOMBESIN-LIKE PEPTIDES INVOLVED IN THE MEDIATION OF STRESS RESPONSE?, Pam Kent, Hymie Anisman, and Zul Merali

Link

Pharmaco-ontogeny of bombesin's suppression of food intake and its attenuation by histamine H3 receptor agonists., Pamela Kent, Hélène Plamondon, and Zul Merali

Link

Effects of interleukin-1β and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study, Zul Merali, Hymie Anisman, and Susan Lacosta

Link

Anorectic action of bombesin requires receptor for corticotropin-releasing factor but not for oxytocin, Hélène Plamondon and Zul Merali

Link

Regulation of ingestion by CRF and bombesin-like peptides: distinct meal-related peptide level changes., Hélène Plamondon and Zul Merali

Submissions from 1996

Link

Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation, Hymie Anisman, Larry Kokkinidis, and Zul Merali

Link

Pharmaco-Ontogenic Modulation of Feeding by Oxytocin, Bombesin, and Their Antagonists, Zul Merali and Hélène Plamondon

Link

Variations of lymphocyte subsets associated with stress in depressive populations, Arun V. Ravindran, Jenna Griffiths, Zul Merali, and Hymie Anisman

Link

Primary dysthymia: A study of several psychosocial, endocrine and immune correlates, A.V Ravindran, Jenna Griffiths, Zul Merali, and Hymie Anisman

Submissions from 1995

Link

Lymphocyte subsets associated with major depression and dysthymia: Modification by antidepressant treatment., Arun V. Ravindran, Jenna Griffiths, Zul Merali, and Hymie Anisman

Link

N-methyl-D-aspartate receptor antagonist activity and phencyclidine-like behavioral effects of the pentadecapeptide, [Ser1]histogranin, Vijay K. Shukla, Simon Lemaire, Michel Dumont, and Zul Merali

Submissions from 1994

Link

Time-dependent in vivo mesolimbic dopamine variations following antigenic challenge, Susan Lacosta, Zul Merali, S. Zalcman, and Hymie Anisman

Link

Does the histaminergic system mediate bombesin/GRP-induced suppression of food intake?, Zul Merali and K Banks

Link

Neuropeptide Y: Intrastriatal injections produce contralateral circling that is blocked by a dopamine antagonist in rats, Elizabeth Moore, Zul Merali, and Richard J. Beninger

Link

Push-pull perfusion reveals meal-dependent changes in the release of bombesin-like peptides in the rat paraventricular nucleus, Hélène Plamondon and Zul Merali

Submissions from 1993

Link

Characterization of Histogranin Receptors in Human Peripheral Blood Lymphocytes, Simon Lemaire, Jenna Griffiths, C Lapierre, I Lemaire, Zul Merali, and A V. Ravindran

Link

Rapid alterations of hypothalamic and hippocampal bombesin-like peptide levels with feeding status, Zul Merali and C C. Kateb

Link

Blockade of brain bombesin/GRP receptors increases food intake in satiated rats, Zul Merali, T W. Moody, and D Coy

Link

Effects of neonatal blockade of bombesin (BN) receptors with [D-Phe6, phi Leu13-Cpa14]BN(6-14) on adult behavior and sensitivity to BN., H D. Piggins, Terry W. Moody, and Zul Merali

Link

Effects of central neuromedin B and related peptides on blood glucose, Hélène Plamondon and Zul Merali

Submissions from 1992

Link

Ontogeny of bombesin/gastrin-releasing peptide binding sites in rat brain, Rena Getz, Carol Merchant, Jeffrey Rosenstein, Zul Merali, and Terry W. Moody

Link

A single meal elicits regional changes in bombesin-like peptide levels in the gut and brain, Claude C. Kateb and Zul Merali

Link

On the ontogenetic and sequential characteristics of bombesin-induced grooming in the infant rat., Hugh Piggins and Zul Merali

Link

Short- and long-term behavioral effects of neonatal exposure to bombesin, Hugh Piggins and Zul Merali

Submissions from 1991

Link

Re-evaluation of the role of dopamine in intracranial self-stimulation using in vivo microdialysis, Elftherios Miliaressis, Claudie Emond, and Zul Merali

Submissions from 1990

Link

Effects of dopamine D1 and D2 receptor agonists and antagonists on bombesin-induced behaviors., Zul Merali and Hugh Piggins

Submissions from 1989

Link

Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: Implications of impaired dopamine function, Qadeer Ahmad and Zul Merali

Link

The effects of concurrent D-1 and D-2 dopamine receptor blockade with sch 23390 and eticlopride, on bombesin-induced behaviours, Hugh Piggins and Zul Merali

Submissions from 1988

Link

The spontaneously diabetic wistar-bb rat manifests altered grooming and catalepsy responses: Implications of impaired dopamine function, Qadeer Ahmad and Zul Merali

Link

Laser or Razor? A Novel Experimental Peripheral Nerve Repair Technique, J C. de la Torre, M Karaca, Zul Merali, T Fortin, and M Richard

Link

Associated norepinephrine loss following calcium-induced spinal paralysis, J C. de la Torre, D Morassutti, Zul Merali, T. Fortin, and M Richard

Link

Specific neuroanatomical and neurochemical correlates of grooming and satiety effects of bombesin, S A. Johnston and Zul Merali

Link

Specific neuroanatomical and neurochemical correlates of locomotor and grooming effects of bombesin, S A. Johnston and Zul Merali

Link

Behavioral and neurochemical profile of the spontaneously diabetic Wistar BB rat, Zul Merali, Qadeer Ahmad, and Jennifer Veitch

Link

(D-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists, Zul Merali, Carol A. Merchant, Jacqueline N. Crawley, David H. Coy, Peter Heinz-Erian, Robert T. Jensen, and Terry W. Moody

Link

The effects of anxiolytics and other agents on rat grooming behavior., T W. Moody, Zul Merali, and J N. CRAWLEY

Submissions from 1985

Link

Role of dopaminergic system(s) in mediation of the behavioural effects of bombesin, Zul Merali, S Johnston, and J Sistek

Submissions from 1983

Link

Bombesin-induced behavioural changes: antagonism by neuroleptics, Zul Merali, S Johnston, and S. Zalcman

Submissions from 1982

Link

Effects of parenteral vanadium administration on pulmonary metabolism of rats, Sam Kacew, Mano R. Parulekar, and Zul Merali

Link

Effects of fluphenazine decanoate (a long-acting phenothiazine) on serum prolactin and amphetamine-induced behavioural changes, Zul Merali and G. Toth

Link

Stress controllability and plasma prolactin levels in the rat, John I. Telner, Zul Merali, and Radhey L. Singhal

Link

Time-dependent changes in plasma prolactin level and stress controllability in rats, John I. Telner, Zul Merali, and Radhey L. Singhal

Submissions from 1981

Link

Prolactin levels and amphetamine-induced behavioural changes following fluphenazine decanoate administration, Zul Merali

Submissions from 1980

Link

DIABETOGENIC EFFECTS OF CHRONIC ORAL CADMIUM ADMINISTRATION TO NEONATAL RATS, Zul Merali and R L. SINGHAL

Submissions from 1979

Link

Alteration of cyclic nucleotide levels in brain following intracranial self-stimulation in the rat, Eleftherios Miliaressis and Zul Merali

Submissions from 1978

Link

Effects of morphine, naloxone, d,l-cyclazocine, and d-amphetamine on behaviour controlled by a schedule of interresponse time reinforcement, Dyane Adam-Carrière, Zul Merali, and Roger Stretch

Submissions from 1977

Link

Sequential changes in hepatic polyamine, deoxyribonucleic acid, and cyclic adenosine 3′,5′-monophosphate metabolism after subacute exposure to cadmium in rats, S. Kacew, Zul Merali, A N. Thakur, and R L. Singhal

Link

Cadmium alters behaviour and the biosynthetic capacity for catecholamines and serotonin in neonatal rat brain, R B. Rastogi, Zul Merali, and R L. Singhal

Submissions from 1976

Link

Cadmium: sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas, S Kacew, Zul Merali, and R L. Singhal