Mental health concerns are now at the top of the list of threats to the economic and social well-being of the people and communities served by AKU. Children and youth, a huge demographic in served countries, are especially vulnerable with large proportions of the population already suffering the lifelong consequences of inaction.​
​The Brain and Mind Institute is a new entity that operates across the Aga Khan University’s multi-country campuses, connecting the rich tapestry of academic entities, and facilitating interdisciplinary research, education and related clinical programming in mental health and neurosciences. The Institute is developing an integrated mental health framework and its work program involves Read more...

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Submissions from 2016

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Zonal Changes in the Ultrastructure of the Epididymal Principal cell of the Greater Cane Rat (Thryonomys swinderianus), A. O. Adebayo, A. K. Akinloye, Amadi O. Ihunwo, V. O. Taiwo, and B. O. Oke

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Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro, H E. Barratt; H C. Budnick; R Parra; R J. Lolley; C N. Perry; and Olivera Nesic Taylor,

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The Distribution of Ki‐67 and Doublecortin Immunopositive Cells in the Brains of Three Microchiropteran Species, Hipposideros fuliginosus, Triaenops persicus, and Asellia tridens, Richard Chawana, Nina Patzke, Abdulaziz N. Alagaili, Nigel C. Bennett, Osama B. Mohammed, Consolate Kaswera, Emmanuel Gilissen, Amadi O. Ihunwo, and Paul R. Manger

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Dose-related effects of chronic resveratrol administration on neurogenesis, angiogenesis, and corticosterone secretion are associated with improved spatial memory retention following global cerebral ischemia, Catrinel Girbovan, Pamela Kent, Zul Merali, and Hélène Plamondon

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Economic assessment of a workplace cognitive behaviour therapy service, David Hitt, Tayyeb Tahir, Lyndon Davies, Srinivas Lanka, Chih Hoong Sin, Karen Naya, and Ann McMahon Ann McMahon

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The dynamics of adult neurogenesis in human hippocampus, Amadi O. Ihunwo, Lackson H. Tembo, and Charles Dzamalala

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Effects of intranasal and peripheral oxytocin or gastrin-releasing peptide administration on social interaction and corticosterone levels in rats, Pamela Kent, Alisha Awadia, Leah Zhao, Donna Ensan, Dinuka Silva, Christian Cayer, Jonathan S. James, Hymie Anisman, and Zul Merali

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Deconstructing the mental health crisis: 5 uneasy pieces, Zul Merali and Hymie Anisman

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Anxiolytic activity and active principles of Piper amalago (Piperaceae), a medicinal plant used by the Q'eqchi' Maya to treat susto, a culture-bound illness, M. Mullally, C. Cayer, A. Muhammad, B. Walshe-Roussel, F. Ahmed, P. E. Sanchez-Vindas, M. Otarola Rojas, Zul Merali, V. Cal, and T. Durst

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Altered monoamine system activities after prenatal and adult stress: A role for stress resilience?, Chris A. Oosterhof, Mostafa E.l. Mansari, Zul Merali, and Pierre Blier

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Gross anatomy curricula and pedagogical approaches for undergraduate physiotherapy students: a scoping review protocol, Dorothy Shead, Roos Ronel, Olivier Benita, and Amadi O. Ihunwo

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Preferred Features of E-Mental Health Programs for Prevention of Major Depression in Male Workers: Results From a Canadian National Survey, JianLi Wang, Raymond W. Lam, Kendall Ho, Mark Attridge, Bonnie M. Lashewicz, Scott B. Patten, Alain Marchand, Alice Aiken, Norbert Schmitz, and Zul Merali

Submissions from 2015

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The coagulating gland in the male greater cane rat (Thryonomys swinderianus): morphological and immunohistochemical features, A. O. Adebayo, A. K. Akinloye, Amadi O. Ihunwo, and B. O. Oke

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Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells, Natasha DeJarnett, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James McCracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, and Jasmit Shah

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Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide, Shawn Hayley, Lisheng Du, Darcy Litteljohn, Miklós Palkovits, Gábor Faludi, Zul Merali, Michael O. Poulter, and Hymie Anisman

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Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells, DeJarnett Natasha, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James McCracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, and Jasmit Shah

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Astrocyte morphology, heterogeneity, and density in the developing African giant rat (Cricetomys gambianus), Matthew A. Olude, Oluwaseun A. Mustapha, Oluwatunde A. Aderounmu, James O. Olopade, and Amadi O. Ihunwo

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Multiple sclerosis and breast cancer, PW O'Malley; ZD Mulla; and Olivera Nesic Taylor,

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Ethnopharmacology of Souroubea sympetala and Souroubea gilgii (Marcgraviaceae) and identification of betulinic acid as an anxiolytic principle, Eva Puniani, Christian Cayer, Pamela Kent, Martha Mullally, Pablo Sánchez-Vindas, Victor Cal, Zul Merali, John T. Arnason, and Tony Durst

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Metabolomics data analysis and missing value issues with application to infarcted mouse hearts, Jasmit Shah, Guy N. Brock, and Shesh N. Rai

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Four clinical concepts: a template for cognitive integration of clinical and basic sciences, Olivera Nesic Taylor,; Dale Quest; Thomas Gest; Debra E. Bramblett; and Dan Blunk

Submissions from 2014

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Structural, ultrastructural and immunohistochemical analysis of the vesicular gland in the male greater cane rat (Thryonomys swinderianus), A. O. Adebayo, A. K. Akinloye, S. G. Olukole, and Amadi O. Ihunwo

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Anatomical and Immunohistochemical Characteristics of the Prostate Gland in the Greater Cane Rat (Thryonomys swinderianus), A. O. Adebayo, A. K. Akinloye, S. G. Olukole, Amadi O. Ihunwo, and B. O. Oke

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Structural, ultrastructural and immunohistochemical analysis of the vesicular gland in the male greater cane rat (Thryonomys swinderianus), A. O. Adebayo, A. K. Akinloye, S. G. Olukole, Amadi O. Ihunwo, and B. O. Oke

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Gross, Histological and Ultrastructural Features of the Bulbourethral Gland in the Greater Cane Rat (Thryonomys swinderianus), A. O. Adebayo; A. K. Akinloye; S. G. Olukole; M. O. Oyeyemi,; V. O. Taiwo; Amadi O. Ihunwo; and B. O. Oke

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Cytokine variations and mood disorders: influence of social stressors and social support, Marie-Claude Audet, Robyn J. McQuaid, Zul Merali, and Hymie Anisman

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Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin, Richard Chawana, Abdulaziz AlagailiAlagaili, Nina Patzke, M. A. Spocter, O. B. Mohammed, Consolate Kaswera, Emmanuel Gilissen, N. C. Bennett, Amadi O. Ihunwo, and Paul R. Manger

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Metabolic remodeling of white adipose tissue in obesity, Timothy D. Cummins, Candice R. Holden, Brian E. Sansbury, Andrew A. Gibb, Jasmit Shah, Nagma Zafar, Yunan Tang, Jason Hellmann, Shesh N. Rai, and Matthew Spite

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Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains, Lisheng Du, Zul Merali, Michael O. Poulter, Miklós Palkovits, Gábor Faludi, and Hymie Anisman

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The cancer drug tamoxifen: a potential therapeutic treatment for spinal cord injury, Jutatip Guptarak; John E. Wiktorowicz; Rovshan G. Sadygov; Dragoslava Zivadinovic; Adriana A Paulucci-Holthauze; Olivera Nesic Taylor,; and Leoncio Vergara

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Effects of electroconvulsive seizures on depression-related behavior, memory and neurochemical changes in Wistar and Wistar-Kyoto rats, C. Kyeremanteng, J. C. MacKay, J. S. James, P. Kent, C. Cayer, H. Anisman, and Zul Merali

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Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food, Jennifer Christine MacKay, Jonathan Stewart James, Christian Cayer, Pamela Kent, Hymie Anisman, and Zul Merali

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Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: similarities to autism spectrum disorders, Zul Merali, J. Presti-Torres, J. C. Mackay, J. Johnstone, L. Du, A. St-Jean, D. Levesque, P. Kent, G. Schwartsmann, and R. Roesler

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The Mini-Mental State Examination as a diagnostic and screening test for delirium: systematic review and meta-analysis, Alex J. Mitchell, Deepak Shukla, Hafsa A. Ajumal, Brendon Stubbs, and Tayyeb Tahir

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Souroubea sympetala (Marcgraviaceae): a medicinal plant that exerts anxiolysis through interaction with the GABAA benzodiazepine receptor, Martha Mullally, Christian Cayer, Kari Kramp, Marco Otárola Rojas, Pablo Sanchez Vindas, Mario Garcia, Luis Poveda Alvarez, Tony Durst, Zul Merali, Vance L. Trudeau, and John T. Arnason

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Adult neurogenesis in the four-striped mice (Rhabdomys pumilio), Olatunbosun O. Olaleye and Amadi O. Ihunwo

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The olfactory bulb structure of African giant rat (Cricetomys gambianus, Waterhouse 1840) I: cytoarchitecture, Ayo Mathew Olude, T. K. Ogunbunmi, J. O. Olopade, and Amadi O. Ihunwo

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Adult neurogenesis in the African giant rat (Cricetomysgambianus, waterhouse), Ayo Mathew Olude, James Olukayode Olopade, and Amadi O. Ihunwo

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Gastrin-releasing peptide receptor signaling in the integration of stress and memory, Rafael Roesler, Pamela Kent, Tatiana Luft, Gilberto Schwartsmann, and Zul Merali

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A multi-loss super regression learner (MSRL) with application to survival prediction using proteomics, Jasmit Shah, Somnath Datta, and Susmita Datta

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Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level, Patricia B de la Tremblaye, Julie Raymond, Marc R. Milot, Zul Merali, and Hélène Plamondon

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Depletion of Circulating CD34+/KDR+ Cells in Type 2 Diabetes is Associated With Glycemic Control, Nagma Zafar, Sathya S. Krishnasamy, Jasmit Shah, James McCracken, Candice R. Holden, Natasha K. DeJarnett, Wesley T. Abplanalp, Bradford G. Hill, Daniel J. Conklin, and Timothy O’Toole

Submissions from 2013

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Characterization of the anxiolytic activity of Nunavik Rhodiola rosea, Christian Cayer, Fida Ahmed, Vicky Filion, Ammar Saleem, Alain Cuerrier, Marc Allard, Guy Rochefort, Zul Merali, and John T. Arnason

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Adult neurogenesis in eight Megachiropteran species, Richard Chawana, Nina Patzke, Consolate Kaswera, Emmanuel Gilissen, Amadi O. Ihunwo, and Paul R. Manger

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Inhibition of IL-6 signaling: a novel therapeutic approach to treating spinal cord injury pain, Jutatip Guptarak; Sheshali Wanchoo; Julieann Durham-Lee; Yewen Wu; Dragoslava Zivadinovic; Adriana Paulucci-Holthauzen; and Olivera Nesic Taylor,

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Soothing the Threatened Brain: Leveraging Contact Comfort with Emotionally Focused Therapy, Susan M. Johnson, Melissa Burgess Moser, Lane Beckes, Andra Smith, Rebecca Halchuk, Karen Hasselmo, Paul S. Greenman, Zul Merali, and James A. Coan

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Stress and eating: a dual role for bombesin-like peptides, Zul Merali, S. Graitson, J. C. MacKay, and P. Kent

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Activation of gastrin-releasing peptide receptors at the infralimbic cortex elicits gastrin-releasing peptide release at the basolateral amygdala: implications for conditioned fear, Zul Merali, C. Mountney, P. Kent, and H. Anisman

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Adult neurogenesis in a giant otter shrew (Potamogale velox), Nina Patzke, Consolate Kaswera, Emmanuel Gilissen, Amadi O. Ihunwo, and Paul R. Manger

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Organization and chemical neuroanatomy of the African elephant (Loxodonta africana) hippocampus, Nina Patzke, Olatunbosun Olaleye, Mark Haagensen, Patrick R. Hof, Amadi O. Ihunwo, and Paul R. Manger

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In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis, Nina Patzke, M. A. Spocter, Karl Æ. Karlsson, Mads F. Bertelsen, Mark Haagensen, Richard Chawana, Sonja Streicher, Consolate Kaswera, Emmanuel Gilissen, Abdulaziz N. Alagaili, Osama B. Mohammed, Roger L. Reep, Nigel C. Bennett, Jerry M. Siegel, Amadi O. Ihunwo, and Paul R. Manger

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Histology and ultrastructure of transitional changes in skin morphology in the juvenile and adult four-striped mouse (Rhabdomys pumilio), Eranée Stewart, Moyosore Salihu Ajao, and Amadi O. Ihunwo

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Development of NMDAR antagonists with reduced neurotoxic side effects: a study on GK11, Delphine Vandame; Lauriane Ulmann; Marisa Teigell; Monica Prieto-Cappellini; Jacques Vignon; Alain Privat; Regino Perez-Polo; Olivera Nesic Taylor,; and Helene Hirbec

Submissions from 2012

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Induction of angiopoietin-2 after spinal cord injury, JC Durham-Lee; Y Wu; VUL Mokkapati; AA Paulucci-Holthauzen; and Olivera Nesic Taylor,

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A study of brain and serum brain-derived neurotrophic factor protein in Wistar and Wistar-Kyoto rat strains after electroconvulsive stimulus, C. Kyeremanteng, J. James, J. Mackay, and Zul Merali

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A refined blood collection method for quantifying corticosterone, Marc R. Milot, Jonathan S. James, Zul Merali, and Hélène Plamondon

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Bombesin receptor regulation of emotional memory, Rafael Roesler, Pamela Kent, Nadja Schroder, Gilberta Schwartsmann, and Zul Merali

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Delirium, Tayyeb Tahir

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Delirium, Tayyeb Tahir

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Molecular pathway reconstruction and analysis of disturbed gene expression in depressed individuals who died by suicide, Vladimir Zhurov, John D. H. Stead, Zul Merali, Miklos Palkovits, Gabor Faludi, Caroline Schild-Poulter, Hymie Anisman, and Michael O. Poulter

Submissions from 2011

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Amiloride improves locomotor recovery after spinal cord injury, Julieann C. Durham-Lee; Venkata Usha L Mokkapati; Kathia M. Johnson; and Olivera Nesic Taylor,

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Effects of intracerebral ventricular administration of gastrin-releasing peptide and its receptor antagonist RC-3095 on learned fear responses in the rat, Zul Merali, Christine Mountney, Pam Kent, and Hymie Anisman

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In vivo levels of corticotropin-releasing hormone and gastrin-releasing peptide at the basolateral amygdala and medial prefrontal cortex in response to conditioned fear in the rat, Christine Mountney, Hymie Anisman, and Zul Merali

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Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae), Martha Mullally, Kari Kramp, Chris Cayer, Ammar Saleem, Fida Ahmed, Calum McRae, John Baker, Andrew Goulah, Marco Otorola, and Zul Merali

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Organisation and chemical neuroanatomy of the African elephant (Loxodonta africana) olfactory bulb, Ayanda Ngwenya, Nina Patzke, Amadi O. Ihunwo, and Paul R. Manger

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Effect of melatonin on neuronal nitric oxide synthase expressing cells in the brain following global cerebral ischemia, Engela Smith Petri, Moyosore Salihu Ajao, Olatunbosun Olaleye, and Amadi O. Ihunwo

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Effect of melatonin on neuronal nitric oxide synthase expressing cells in the brain following global cerebral ischemia, Engela Smith Petri, Moyosore Salihu Ajao, Olatunbosun Olaleye, and Amadi O. Ihunwo

Submissions from 2010

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Perspectives on neonatal hypoxia/ischemia-induced edema formation, Diana Carolina Ferrari; Olivera Nesic Taylor,; and Jose Regino Perez-Polo

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Cell proliferation and total granule cell number in dentate gyrus of transgenic Tg2576 mouse, Amadi O. Ihunwo and Reinhard Schliebs

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Altered Organization of GABA(A) Receptor mRNA Expression in the Depressed Suicide Brain, Michael O. Poulter, Lisheng Du, Vladimir Zhurov, Miklós Palkovits, Gábor Faludi, Zul Merali, and Hymie Anisman

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A randomized controlled trial of quetiapine versus placebo in the treatment of delirium, Tayyeb Tahir, Eamonn Eeles, Venugopal Karapareddy, Prem Muthuvelu, Sian Chapple, Bethan Phillips, Toyin Adyemo, Daniel Farewell, and Jonathan I. Bisson

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Aquaporins in spinal cord injury: the janus face of aquaporin 4, Olivera Nesic Taylor,; J. D. Guest; D. Zivadinovic; P. A. Narayana; J .J. Herrera; R. J. Grill; V. U.L Mokkapati; B. B. Gelman; and J. Lee

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Vascular Endothelial Growth Factor and Spinal Cord Injury Pain, Olivera Nesic Taylor,; Laura M. Sundberg; Juan J. Herrera; Venkata U.L . Mokkapati; Julieann Lee; and Ponnada A. Narayana

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Vascular endothelial growth factor and spinal cord injury pain, Olivera Nesic Taylor,; Laura M. Sundberg; Juan J. Herrera; Venkata UL Mokkapati; Julieann Lee; and Ponnada A. Narayana

Submissions from 2009

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Ethnopharmacology of Q’eqchi’ Maya antiepileptic and anxiolytic plants: Effects on the GABAergic system, Rosalie Awad, Fida Ahmed, Natalie Bourbonnais-Spear, Martha Mullally, Chieu Anh Ta, Andrew Tang, Zul Merali, Pedro Maquin, Francisco Caal, and Victor Cal

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Behavioural Patterns and Corticosterone Levels Induced by Chronic Psychosocial Stress in the Four-Striped Mice (Rhabdomys pumilio), Thirosha Chetty, Moyosore Salihu Ajao, Paul R. Manger, and Amadi O. Ihunwo

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Behavioural Patterns and Corticosterone Levels Induced by Chronic Psychosocial Stress in the Four-Striped Mice (Rhabdomys pumilio), Thirosha Chetty, Moyosore Salihu Ajao, Paul R. Manger, and Amadi O. Ihunwo

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Comparison of clinical assessment and actigraphy in the characterization of delirium, Eamonn M P Eeles, Tayyeb Tahir, Antony Johansen, Jonathon I Bisson Jonathon I Bisson, and Ruth E. Hubbard

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Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary, Zul Merali, S. Hayley, P. Kent, J. McIntosh, T. Bédard, and H. Anisman

Submissions from 2008

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Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects, Hymie Anisman, Lisheng Du, Mikos Palkovits, Gabor Faludi, Gabor G. Kovacs, Peter Szontagh-Kishazi, Zul Merali, and Michael O. Poulter

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Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders, Hymie Anisman, Zul Merali, and Shawn Hayley

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Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies, Hymie Anisman, Zul Merali, and John D. H. Stead

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Drug treatment of delirium: past, present and future, Richard S. Bourne, Tayyeb Tahir, Mark Borthwick, and Elizabeth L. Sampson

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Distribution and morphology of putative catecholaminergic and serotonergic neurons in the brain of the greater canerat, Thryonomys swinderianus, Sarika Dwarika, Busisiwe c. Maseko, Amadi O. Ihunwo, Kjell Fuxe, and Paul R. Manger

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Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions, Bruno P. Guiard, Mostafa E.l. Mansari, Zul Merali, and Pierre Blier

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Anatomy: Spotlight on Africa, Beverley Kramer, Nalini Pather, and Amadi O. Ihunwo

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Effects of corticosterone on corticotrophin-releasing hormone and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex), Zul Merali, Hymie Anisman, Jonathan S. James, Pam Kent, and Jay Schulkin

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Nesfatin-1 increases anxiety- and fear-related behaviors in the rat, Zul Merali, C. Cayer, P. Kent, and H. Anisman

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Effects of gastrin-releasing peptide agonist and antagonist administered to the basolateral nucleus of the amygdala on conditioned fear in the rat, Christine Mountney, Hymie Anisman, and Zul Merali

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GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes, Michael O. Poulter, Lisheng Du, Ian C.G. Weaver, Miklós Palkovits, Gábor Faludi, Zul Merali, Moshe Szyf, and Hymie Anisman

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Nuclear factor-κB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes, Danny Salah Rafati; Katja Geissle; Kathia Johnson; Geda Unabia; Claire Hulsebosch; Olivera Nesic Taylor,; and J. Regino Perez-Polo

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Nuclear organization and morphology of serotonergic neurons in the brain of the Nile crocodile, Crocodylus niloticus, Stacey-Le Rodrigues, Busisiwe c. Maseko, Amadi O. Ihunwo, Kjell Fuxe, and Paul R. Manger

Submissions from 2007

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Interferon-α effects are exaggerated when administered on a psychosocial stressor backdrop: Cytokine, corticosterone and brain monoamine variations, Hymie Anisman, Michael O. Poulter, Reno Gandhi, Zul Premji, and Shawn Hayleya

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Corticotropin releasing hormone receptor alterations elicited by acute and chronic unpredictable stressor challenges in stressor-susceptible and resilient strains of mice, Hymie Anisman, Priya Prakash, Zul Merali, and Michael O. Poulter

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Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system, R. Awad, D. Levac, P. Cybulska, V. L. Trudeau, Zul Merali, and J. T. Arnason

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Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior, Tania Bédard, Christine Mountney, Pam Kent, Hymie Anisman, and Zul Merali

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Ethnopharmacological investigation of plants used to treat susto, a folk illness, Natalie Bourbonnais-Spear, Rosalie Awad, Zul Merali, Pedro Maquin, Victor Cal, and John Thor Arnason

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Phosphorylation of Bcl-xL after spinal cord injury, Diana M. Cittelly; Olivera Nesic Taylor,; and Jose Regino Perez-Polo

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Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors, Reno Gandhi, Shawn Hayley, Julie Gibb, Hymie Anisman, and Zul Merali

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Psychosocial Stress Evoked by a Virtual Audience: Relation to Neuroendocrine Activity, Owen Kelly, Kimberly Matheson, Alejandra Martinez, Zul Merali, and Hymie Anisman