Bombesin-induced HPA and sympathetic activation requires CRH receptors
Document Type
Article
Department
Brain and Mind Institute
Abstract
Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.
Publication (Name of Journal)
Peptides
Recommended Citation
Kent, P.,
Bédard, T.,
Khan, S.,
Anisman, H.,
Merali, Z.
(2001). Bombesin-induced HPA and sympathetic activation requires CRH receptors. Peptides, 22(1), 57-65.
Available at:
https://ecommons.aku.edu/bmi/158
Comments
This work was published before the author joined Aga Khan University.