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Submissions from 2021

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Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase, Syed Hani Abidi, Nahlah Makki Almansour, Daulet Amerzhanov, Khaled S. Allemailem, Wardah Rafaqat, Mahmoud A A. Ibrahim, Philip la Fleur, Martin Lukac, and Syed Ali

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Phylogenetic and drug-resistance analysis of HIV-1 sequences from an extensive paediatric HIV-1 outbreak in Larkana, Pakistan, Syed Hani Abidi, George Makau Nduva, Dilsha Siddiqui, Wardah Rafaqat, Syed Faisal Mahmood, Amna Rehana Siddiqui, Apsara Ali, Aneeta Hotwani, Rashida Abbas Ferrand, and Fatima Mir

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Therapeutic potential of curcumin in reversing the depression and associated pseudodementia via modulating stress hormone, hippocampal neurotransmitters, and BDNF levels in Rats, Asia Afzal, Zehra Batool, Sadia Sadir, Laraib Liaquat, Sidrah Shahzad, Saiqa Tabassum, Saara Ahmad, Noor Kamil, Tahira Perveen, and Saida Haider

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Is hypothyroidism associated with outcomes in fracture patients? Data from a trauma registry, Tashfeen Ahmad, Zehra Abdul Muhammad, and Sarah Nadeem

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Student research mentorship programme: A novel solution for promoting research in medical school, Inaara Akbar, Russell Seth Martins, and Syeda Sadia Fatima

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Multi-subunit SARS-CoV-2 vaccine design using evolutionarily conserved T- and B- cell epitopes, Burkitkan Akbay, Syed Hani Abidi, Mahmoud A A. Ibrahim, Zhussipbek Mukhatayev, and Syed Ali

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Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross-sectional study in Pakistan, Faiza Alam, Rehana Rehman, Syeda Sadia Fatima, Mussarat Ashraf, and Taseer Ahmed Khan

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Association of novel stop-gained leukaemia inhibitory factor receptor gene (rs121912501) variant, leukaemia inhibitory factor and ovarian steroids with unexplained infertility among Pakistani women, Rabiya Ali, Mehir Un Nisa Iqbal, Rehana Rehman, and Taseer A. Khan

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General public perception of social media, impact of covid-19 pandemic, and related misconceptions, Rabiya Ali, Shireen Jawed, Mukhtiar Baig, Ahmed Azam Malik, Fatima Syed, and Rehana Rehman

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Impact of a standardised parenteral nutrition protocol: A quality improvement experience from a NICU of a developing country, Gul Ambreen, Uswa Jiwani, Waqar Khowaja, Ali Shabbir Hussain, Kashif Hussain, Syed Shamim Raza, Arjumand Rizvi, Uzair Ansari, Khalil Ahmad, Simon Demas, and Shabina Ariff

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Protamine 1/protamine 2 mRNA ratio in nonobstructive azoospermic patients, Sofia Amjad, Shamim Mushtaq, Rehana Rehman, Adnan Munir, Nida Zahid, and Pirzada Qasim Raza Siddique

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Spermatozoa retrieval in azoospermia and expression profile of JMJD1A, TNP2, and PRM2 in a subset of the Karachi population, Sofia Amjad, Shamim Mushtaq, Rehana Rehman, Nida Zahid, Adnan Munir, and Pirzada Qasim Raza Siddiqui

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Molecular and radiological characterization of glioblastoma multiforme using magnetic resonance imaging, Fazal M. Arain, Anjiya Shaikh, Muhammad Waqas, Muhammad Usman Tariq, Muhammad Faraz Raghib, Ghulam Haider, Muhammad Shahzad Shamim, Fatima Mubarak, Sheema H Hasan, Syed Ather Enam, and Adnan Abdul Jabbar

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Morphological changes in the experimental model of polycystic ovary syndrome and effects of vitamin D treatment, Arfa Azhar, Ghulam Haider, Zehra Naseem, Nida Farooqui, Mohammad U. Farooqui, and Rehana Rehman

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Targeting neuroinvasion by SARS-CoV-2: Emerging trends in drug and antibody delivery to combat COVID-19, Abdul Mannan Baig

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Docking prediction of levodopa in the receptor binding domain of spike protein of SARS-CoV-2, Abdul Mannan Baig, Areeba Khaleeq, Hira Syeda, and Noor Bibi

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'Targeting the feast of a sleeping beast': Nutrient and mineral dependencies of encysted acanthamoeba castellanii, Abdul Mannan Baig, Naveed Ahmed Khan, Preet Katyara, Salima Lalani, Rozeena Baig, Mehdia Nadeem, Noor Akbar, Fizza Nazim, and Areeba Khaleeq

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Online medical education and examinations during COVID-19: Perspectives of a teaching associate, Syed Mujtaba Baqir and Fatima Mustansir

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Flipped laboratory sessions using video vignette and active learning: A hybrid approach for online teaching, Sabah Farhat, Rehana Rehman, and Syeda Sadia Fatima

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Online assessment in undergraduate medical education: Challenges and solutions from a LMIC university, Syeda Sadia Fatima, Romana Idrees, Kauser Jabeen, Saniya Sabzwari, and Sadaf Khan

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Association of chemerin gene promoter methylation in maternal blood and breast milk during gestational diabetes, Syeda Sadia Fatima, Rehana Rehman, Jibran Sualeh Muhammad, Russell S. Martins, Nuruddin Badruddin Mohammed, and Unab Khan

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Spasmolytic effect of grewia asiatica fruit extract on isolated smooth muscles is mediated via multiple pathways, Muhammad Nabeel Ghayur, Saeed Ahmad, and Anwarul Hassan Gilani

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Meropenem-induced pancytopenia in a preterm neonate: A case report, Kashif Hussain, Muhammad Sohail Salat, Naureen Mohammad, Ambreen Mughal, Sidra Idrees, Javaid Iqbal, and Gul Ambreen

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Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies, Maria Iqbal, Reza Maroofian, Büşranur Çavdarlı, Florence Riccardi, Michael Field, Siddharth Banka, Dalal K. Bubshait, Yun Li, Jozef Hertecant, and Shahid Mahmood Baig

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Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction, Zehra Jamil, Najeeha Talat Iqbal, Romana Idress, Zubair Ahmad, Kamran Sadiq, Junaid Iqbal, Sana Syed, Aneeta Hotwani, Furqan Kabir, Kumail Ahmed, Sheraz Ahmed, Fayyaz Umrani, Fatima Aziz, Adil Kalam, and Syed Asad Ali

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Level I nodal positivity as a factor for involvement of the submandibular gland in oral cavity carcinoma: A case series report, Hamdan Ahmed Pasha, Rahim Dhanani, Shayan Khalid, Kulsoom Ghias, and Mumtaz Jamshed Khan

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Endometriosis, infertility and MicroRNA's: A review, Mohummad Hasan Raza Raja, Nida Farooqui, Nadeem Zuberi, Mussarat Ashraf, Arfa Azhar, Rozeena Baig, Bisma Badar, and Rehana Rehman

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A novel missense mutation in TNNI3K causes recessively inherited cardiac conduction disease in a consanguineous Pakistani family, Shafaq Ramzan, Stephanie Tennstedt Stephanie Tennstedt, Muhammad Tariq, Sheraz Khan, Hafiza Noor Ul Ayan, Aamir Ali, Matthias Munz, Holger Thiele, Asad Aslam Korejo, and Shahid Mahmood Baig

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Editorial: Vitamin D deficiency and sufficiency in reproduction and bone metabolism, Rehana Rehman, Faiza Alam, Mukhtiar Baig, Aysha Habib Khan, and Naseer Ahmed

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An innovation in flipped class room: A teaching model to facilitate synchronous and asynchronous learning during a pandemic, Rehana Rehman and Syeda Sadia Fatima

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COVID-19 pandemic awareness, attitudes, and practices among the Pakistani general public, Rehana Rehman, Shireen Jawed, Rabiya Ali, Khola Noreen, Mukhtiar Baig, and Javaria Baig

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Biomarkers for impending risk of osteoporosis in premenopausal women, Rehana Rehman, Ali Usman, Aisha Sheikh, and Rozeena Baig

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Probabilistic measures of HIV-1 transmission in different HIV-1 key population groups of Larkana, Pakistan, Syed Rizwan-Ul-Hasa, Abiha Abdullah, Shakil Arshad Siddiqui, Shakil Ahmed, Sharaf Ali Shah, Fatima Mir, and Syed Hani Abidi

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COVID-19 age-dependent immunology and clinical outcomes: Implications for vaccines, Azza Sarfraz, Saman Hasan Siddiqui, Junaid Iqbal, Syed Asad Ali, Zahra Hasan, Zouina Sarfraz, and Najeeha Talat Iqbal

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Male infertility: Role of vitamin D and oxidative stress markers, Maheen Shahid, Sher Khan, Mussarat Ashraf, Hina Akram Mudassir, and Rehana Rehman

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Relationship of BMI with Junk Food, sleep pattern, exam performance and awareness about its ill health effects in healthy teenagers, Saba Tariq, Sundus Tariq, Saffee Tariq, and Rehana Rehman

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Pericardial fluid proteomic label-free quantification of differentially expressed proteins in ischemic heart disease patients with systolic dysfunction by nano-LC-ESI-MS/MS analysis, Junaid Ullah, Satwat Hashmi, Arslan Ali, Faisal Khan, Shahid Ahmed Sami, Nageeb Basir, Syedah Saira Bokhari, Hasanat Sharif, Hesham R. El-Seedi, and Syed Ghulam Musharraf

Submissions from 2020

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Depression screening, a prerequisite in patients undergoing investigative proto-oncogene mutation tests, Saara Ahmad, Asra Khan, and Bisma Badr

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Functional and clinical outcomes of open versus closed radius and ulna shaft fractures in adults: A prospective cohort study, Tashfeen Ahmad, Zehra Abdul Muhammad, and Pervaiz Hashmi

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Analysis of anti-microbial and anti-biofilm activity of hand washes and sanitizers against S. aureus and P. aeruginosa, Khalid Ahmed, Hamza Ahmed, Fasih Ali Ahmed, Alisha Akbar Ali, Jehangir Akbar, Junaid Rana, Uroosa Tariq, and Syed Hani Abidi

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Fingolimod (FTY720) preserves high energy phosphates and improves cardiac function in heterotopic heart transplantation model, Naseer Ahmed, Javeria Farooq, Soban Sadiq, Sultan Ayoub Meo, Azam Jan, Faisal H. Cheema, Giuseppe Faggian, and Alessio Rungatscher

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Protective role of peroxiredoxin-4 in heart failure, Naseer Ahmed, Masooma Naseem, and Javeria Farooq

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Clinicopathologic features predictive of distant metastasis in patients diagnosed with invasive breast cancer, Basim Ali, Fatima Mubarik, Nida Zahid, and Abida K. Sattar

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Galectin-3: A cardiomyocyte antiapoptotic mediator at 24-hour post myocardial infarction, Suhail Al-Salam, Satwat Hashmi, Govindan S. Jagadeesh, and Saeed Tariq

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Neonatal fluid and electrolytes profile effect on amphotericin B associated nephrotoxicity in neonatal tertiary care unit of Karachi-Pakistan, Gul Ambreen, Arshalooz Rahman, Kashif Hussain, Mehreen Sohail, Saba Javed, Syed Shamim, Umer Ali, Khalil Ahmad, and Arjumand Rizvi

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Efficacy of colistin in multidrug-resistant neonatal sepsis: Experience from a tertiary care center in Karachi, Pakistan, Gul Ambreen, Muhammad Sohail Salat, Kashif Hussain, Syed Shamim Raza, Umer Ali, Syed Iqbal Azam, Junaid Iqbal, and Zafar Fatmi

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Association of long-term consumption of repeatedly heated mix vegetable oils in different doses and hepatic toxicity through fat accumulation, Gul Ambreen, Afshan Siddiq, and Kashif Hussain

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Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of murraya koenigii, Gul Ambreen, Afshan Siddiq, Kashif Hussain, Abdul Saboor Hussain, and Zara Naz

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Synonymous polymorphism rs201256011 in dopamine receptor type 2 gene is associated with schizophrenia and PANSS score in Pakistani population: A first report, Qurat-Ul-Ain Amir, Farina Hanif, Washdev Washdev, Fareena Bilwani, and Shabana Usman Simjee

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Application of an integrated cheminformatics-molecular docking approach for discovery for physicochemically similar analogs of fluoroquinolones as putative HCV inhibitors, Faraz Anwar, Ramsha Khalid, Alina Hasanain, Sadaf Naeem, Shamshad Zarina, Syed Hani Abidi, and Syed Ali

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Polycystic ovary syndrome, subfertility and vitamin D deficiency, Arfa Azhar, Fatima Abid, and Rehana Rehman

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Can neurotropic free-living amoeba serve as a model to study SARS-CoV-2 pathogenesis?, Abdul Mannan Baig

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Chronic COVID syndrome: Need for an appropriate medical terminology for Long-COVID and COVID long-haulers, Abdul Mannan Baig

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Computing the effects of SARS-CoV-2 on respiration regulatory mechanisms in COVID-19, Abdul Mannan Baig

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Covert pathways to the cranial cavity: Could these be potential routes of SARS-CoV-2 to the brain?, Abdul Mannan Baig

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Neurological manifestations in COVID-19 caused by SARS-CoV-2, Abdul Mannan Baig

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Updates on what ACS reported: Emerging evidences of COVID-19 with nervous system involvement, Abdul Mannan Baig

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Ocular COVID-19: Eyes as a reservoir to conceal and spread SARS-CoV-2, Abdul Mannan Baig, Saara Ahmad, Areeba Khaleeq, Hamna Rafique, Shafiqa Rajput, Meher Angez, Ayesha Nasir Hameed, Talha Nawaz, and Preet Katyara

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Evidence of the COVID-19 virus targeting the CNS: Tissue distribution, host-virus interaction, and proposed neurotropic mechanisms, Abdul Mannan Baig, Areeba Khaleeq, Usman Ali, and Hira Syeda

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Elucidation of cellular targets and exploitation of the receptor-binding domain of SARS-CoV-2 for vaccine and monoclonal antibody synthesis, Abdul Mannan Baig, Areeba Khaleeq, and Syeda Hira

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Docking prediction of amantadine in the receptor binding domain of spike protein of SARS-CoV-2, Abdul Mannan Baig, Areeba Khaleeq, and Hira Syeda

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Deleterious outcomes in long-hauler COVID-19: The effects of SARS-CoV-2 on the CNS in chronic COVID syndrome, Abdul Mannan Mannan Baig

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Future oncotargets: Targeting overexpressed conserved protein targets in androgen independent prostate cancer cell lines, Abdul Mannan Baig, Zohaib Rana, Mohammad Mohsin Mannan, Areeba Khaleeq, Fizza Nazim, Preet Katyara, and Farhat Abbas

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Heralding healthcare professionals: Recognition of neurological deficits in COVID-19, Abdul Mannan Baig and Erin C. Sanders

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Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease 2019 (COVID-19), Abdul Mannan Baig and Erin C. Sanders

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Survival on the heart transplant waiting list, Syed Shahyan Bakhtiyar, Elizabeth L. Godfrey, Shayan Ahmed, Harveen Lamba, Jeffrey Morgan, Gabriel Loor, Andrew Civitello, Faisal H. Cheema, Whitson B. Etheridge, John Goss, and Abbas Rana

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Is dengue the new rising global health problem? The outbreak of 2019 in Pakistan, Mariam Baloch, Abdul Mannan Baig, and Rohan K. Ochani

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Comparison of intraarticular distal humerus fracture outcomes treated with or without olecranon osteotomy - A case series, Naveed Baloch, Tashfeen Ahmad, and Zehra Abdul Muhammad

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What does it mean for a case to be ‘local’? The importance of local relevance and resonance for bioethics education in the Asia-pacific region, Sara M. Bergstresser, Kulsoom Ghias, Stuart Lane, Wee-Ming Lau, Isabel S S. Hwang, Olivia M Y. Ngan, Robert L. Klitzman, and Ho Keung Ng

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Alcohol consumption and obesity: The hidden scare with COVID-19 severity, Bushra Bilal, Faizan Saleem, and Syeda Sadia Fatima

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Physician-scientist or basic scientist? Exploring the nature of clinicians' research engagement, Anna T. Cianciolo, Jordon Mitzelfelt, Allen Ghareeb, Mohammad Faizan Zahid, Rozmeen Akbar, and Kulsoom Ghias

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Revisiting respiratory syncytial virus's interaction with host immunity, towards novel therapeutics, C Efstathiou, Syed Hani Abidi, J Harker, and N J. Stevenson

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Role of some MiRNA affecting polycystic ovarian syndrome and SIRT1 levels, Nida Farooqui, Quratulain Maha, and Rehana Rehman

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Paediatric porphyria and human hemin: A treatment challenge in a lower middle income country, Syeda Anum Fatima, Humaira Jurair, Qalab Abbas, and Arshalooz Rahman

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Impact of humanities and social sciences curriculum in an undergraduate medical education programme, Kulsoom Ghias, Kausar S. Khan, Rukhsana Ali, Shireen Azfar, and Rashida Ahmed

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Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress, Saida Haider, Laraib Liaquat, Saara Muddasir, Zehra Batool, Rafat Ali Siddiqui, Saiqa Tabassum, Sidrah Shahzad, Sahar Rafiq, and Narjis Naz

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Supplementation of taurine insulates against oxidative stress, confers neuroprotection and attenuates memory impairment in noise stress exposed male wistar rats, Saida Haider, Irfan Sajid, Zehra Batool, Syeda Madiha, Sadia Sadir, Noor Kamil, Laraib Liaquat, Saara Ahmad, Saiqa Tabassum, and Saima Khaliq

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A novel variant in dopamine receptor type 2 gene is associated with schizophrenia, Farina Hanif, Qurat-Ul-Ain Amir, Washdev Washdev, Fareena Bilwani, Shabana Usman Simjee, and Zeba Haque

Introduction to research ethics and integrity, Satwat Hashmi and Ehtisham Altaf

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An antibiotic stewardship program in a surgical ICU of a resource-limited country: Financial impact with improved clinical outcomes, Kashif Hussain, Muhammad Faisal Khan, Gul Ambreen, Syed Shamim Raza, Seema Irfan, Kiren Habib, and Hasnain Zafar

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Neurodevelopment outcome of neonates treated with intraventricular colistin for ventriculitis caused by multiple drug-resistant pathogens-A case series, Kashif Hussain, Muhammad Sohail Salat, Gul Ambreen, and Javaid Iqbal

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Intravenous vs intravenous plus aerosolized colistin for treatment of ventilator-associated pneumonia - A matched case-control study in neonates, Kashif Hussain, Muhammad Sohail Salat, Gul Ambreen, Ambreen Mughal, Sidra Idrees, Mehreen Sohail, and Javaid Iqbal

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Manuscript writing and publication workshop: An invoking pilot study on enhancing cognitive research capabilities in health sciences institutes of Pakistan, Mehwish Hussain, Rehana Rehman, and Mukhtiar Baig

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Neurological manifestations of COVID-19, Dureshahwar Kanwar, Abdul Mannan Baig, and Mohammad Wasay

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An in silico approach to analyze HCV genotype-specific binding-site variation and its effect on drug-protein interaction, Ramsha Khalid, Muhammad Faraz Anwar, Muhammad Aanish Raees, Sadaf Naeem, Syed Hani Abidi, and Syed Ali

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Ionomic profiling of pericardial fluid in ischemic heart disease, Noman Khan, Satwat Hashmi, Amna Jabbar Siddiqui, Sabiha Farooq, Shahid Ahmed Sami, Nageeb Basir, Syedah Saira Bokhari, Hasanat Sharif, Sanaullah Junejo, and Syed Ghulam Musharraf

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Understanding of metals dysregulation in patients with systolic and diastolic dysfunction in ischemic heart disease, Noman Khan, Satwat Hashmi, Amna Jabbar Siddiqui, Sabiha Farooq, Shahid Ahmed Sami, Nageeb Basir, Syeda Saira Bokhari, Hasanat Sharif, Sanaullah Junejo, Hesham R. El-Seedi, and Syed Ghulam Musharraf

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Technology-based learning tools in medical lab sessions, Sher Khan, Asra Khan, and Saara Ahmad

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Effects of feed additives on chicken growth and their residues in meat instigating deleterious consequences on the liver health of consumers - A prospective human study, Saara Muddasir, Iftikhar Ahmed, Saida Haider, Zehra Batool, Laraib Liaquat, Fatima Ahmed, Asra Khan, Tahira Perveen, Mirza Jawad ul Hasnain, Saima Khaliq, and Saad Bilal Ahmed

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Relation of copeptin with diabetic and renal function markers among patients with diabetes mellitus progressing towards diabetic nephropathy, Tooba Noor, Farina Hanif, Zareen Kiran, Rehana Rehman, Muhammad Tassaduq Khan, Zeba Haque, and Kelash Nankani

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Knowledge, attitudes, and practices against the growing threat of COVID-19 among medical students of Pakistan, Khola Noreen, Zil-E Rubab, Muhammad Umar, Rehana Rehman, Mukhtiar Baig, and Fizzah Baig

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Outbreak of coronavirus disease 2019 (COVID 19) in Pakistan: Psychological impact and coping strategies of health care professionals, Khola Noreen, Muhammad Umar, Syed Arshad Sabir, and Rehana Rehman

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Multiple mechanisms of flaxseed: Effectiveness in inflammatory bowel disease, Amber Hanif Palla, Anwar Gilani, Samra Bashir, and Najeeb Ur Rehman

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Association of polymorphism c.-124G>A and c.-16 C>T in the promoter region of human INHA gene with altered sperm parameters; a pilot study, Wardah Rafaqat, Muhammad Rohan Kayani, Tasneem Fatima, Saeeda Shaharyar, Shagufta Khan, Mussarat Ashraf, Usman Afzal, and Rehana Rehman

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Association of circulatory kisspeptin levels and hormonal interplay with male infertility: A cross-sectional study in Karachi, Pakistan, Rehana Rehman, Kaleem Ahmed, Nida Zahid, Faiza Alam, and Syeda Sadia Fatima

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Oxidative stress and male infertility: A cross sectional study, Rehana Rehman, Sofia Amjad, Hemaila Tariq, Nida Zahid, Masnoon Akhter, and Mussarat Ashraf

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Teaching "shock pathophysiology" by flipped classroom: Views and perspectives, Rehana Rehman, Satwat Hashmi, Rozmeen Akbar, and Syeda Sadia Fatima

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Role of oxidative stress and altered thyroid hormones in unexplained infertility, Rehana Rehman, Hiba Ismail Rajpar, Mussarat Ashraf, Najeeha Talat Iqbal, Salima Lalani, and Faiza Alam

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Impact of wellness indicators on intellectual dimensions of medical teachers of Karachi: Findings from cross sectional study, Rehana Rehman, Sadiqa Syed, Mehwish Hussain, Tayyab Raza Fraz, and Saif Ullah Shaikh

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Impact of serum and follicular fluid kisspeptin and estradiol on oocyte maturity and endometrial thickness among unexplained infertile females during ICSI, Rehana Rehman, Amara Zafar, Arzina Aziz Ali, Mukhtiar Baig, and Faiza Alam