Dengue fever Igg sero-prevalence and associated factors in apparently healthy population age 15 To 60 years in South Kordofan State, Sudan 2012
Date of Award
2012
Document Type
Thesis
Degree Name
Master of Science in Epidemiology & Biostatistics (MSc Epidemiology & Biostats)
Department
Community Health Sciences
Abstract
Background: Dengue is a vector-borne virus, which is transmitted to humans by infected Aedes mosquitoes. Dengue is currently classified as the most predominant mosquito born disease since its burden have been rising in the recent years and become a public health problem of global importance. Dengue is documented to have occurred in Sudan, mainly in eastern part including Red Sea and Kassalastates. South Kordofan state is known to have the presence of the responsible vector in addition to the free movement within Sudan. It is also a border state with the new republic of South Sudan in addition to confirmation of many sporadic dengue cases and no previous studies were conducted, this ranked it as a priority state to be investigated. Objectives: To estimate the prevalence of Dengue IgG antibodies in Lagawa locality population age 16-60 years in 2012 and to identify the main associated predictors for this outcome. Methodology: A cross sectional community-based study conducted in Lagawa locality in 2012. The sample size was 600 obtained by a multi stage cluster sampling technique. A structured questionnaire and blood sample testing were used to obtainour data. Results: Overall Dengue IgG prevalence was found to be 27.7% in Lagawa locality. Inspected indoor mosquito breeding was found to be the most significant predictor of dengue IgG serological outcome. Water storage at households is associated with our outcome. Participants who reside in greater Lagawa popular administrative units were found to be at higher risk of DF IgG serological outcome than those who are living out of Lagawa. Male participants were at lower risk of DF IgG compared to females. Younger participants (<35 years) found to be at greater risk for DF IgG compared to the elders. Travelling history to Red Sea State and north South Sudan was found to be a significantly predicting the outcome adjusted. History of fever during the preceding three months is associated with higher risk of DF IgG serological outcome. Mosquito nets use is shown to be a protective tool in our analysis, particularly when the participant uses the net during both day and night. In addition those who use the nets on daily basis are more protected than interruptedly use them.Interestingly we did not find an evidence for cross immunity with other favi virus since Yellow fever vaccination was found to be not significantly associated with DF IgG positivity. Many other socio-demographic factors were found not to be significantly associated with DF IgG serological outcome in Lagawa locality in this study. Conclusion: Dengue looks to be having a burden in Lagawa locality on the top of its current complicated political and geographical contexts. Our results suggesting the high contribution of indoor (household) behaviors predisposing to Dengue infection by sustaining some risky behaviors that needs to be corrected and looked at. We need to raise the community awareness about dengue fever in Lagawa locality and implement a vector control program with community participation.
Recommended Citation
Soghaier, M. A. (2012). Dengue fever Igg sero-prevalence and associated factors in apparently healthy population age 15 To 60 years in South Kordofan State, Sudan 2012 (Unpublished doctoral thesis). Aga Khan University, Karachi, Pakistan.