Document Type
Article
Department
Paediatrics and Child Health
Abstract
Rotavirus (RV) is the leading cause of diarrhea-related death in children worldwide and ninety-five percent of rotavirus deaths occur in Africa and Asia. Rotavirus vaccines (RVV) can dramatically reduce RV deaths, but have low efficacy in low-income settings where they are most needed. The intestinal microbiome may contribute to this decreased RVV efficacy. This pilot study hypothesizes that infants' intestinal microbiota composition correlates with RVV immune responses and that RVV responders have different gut microbiota as compared to non-responders. We conducted a nested, matched case-control study comparing the pre-vaccination intestinal microbiota composition between 10 6-week old Pakistani RVV-responders, 10 6-week old Pakistani RVV non-responders, and 10 healthy Dutch infants. RVV response was defined as an Immunoglobulin A of ≥20 IU/mL following Rotarix™(RV1) vaccination in an infant with a pre-vaccination IgA
Publication (Name of Journal)
Gut Microbes
Recommended Citation
Harris, V.,
Ali, S.,
Fuentes, S.,
Kazi, A.,
Tate, J.,
Parashar, U.,
Wiersinga, W.,
Giaquinto, C.,
Weerth, C. D.,
Vos, W. D.
(2018). Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan. Gut Microbes, 9(2), 93-101.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/703
Comments
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