Neonatal sepsis in Pakistan Presentation and pathogens
Document Type
Article
Department
Paediatrics and Child Health
Abstract
The case records of all neonates admitted to the neonatal unit at Aga Khan University Hospital (Karachi) in a 30 month period (Nov. 86-April 89) were analysed. Of 60 neonates with confirmed sepsis, 33 (55%) had non-nosocomial infection (NNC) whereas 27 (45%) had nosocomial sepsis (NC). The most common organisms causing early-onset NNC sepsis were Klebsiella species (53%) and Escherichia coli (10%), whereas the organisms causing late-onset NNC sepsis included Salmonella parathypi (21%), Group A Streptococcus (21%), Escherichia coli (14%) and Pseudomonas species (14%). Klebsiella was the most common organism causing NC sepsis, others being Staphylococcus aureus (15%) and Serratia species (15%). The mortality in NC sepsis, early-onset and late onset NNC sepsis was 44%, 26% and 43%, respectively. Risk factors associated with NNC sepsis included low birthweight, prematurity and prolonged and complicated deliveries. There was a high incidence of drug resistance to ampicillin and gentamicin among gram-negative organisms causing sepsis (mean 67%).
Publication (Name of Journal)
Acta Paediatrica Scandinavica
Recommended Citation
Bhutta, Z. A.,
Naqvi, S. H.,
Muzaffar, T.,
Farooqui, B. J.
(1991). Neonatal sepsis in Pakistan Presentation and pathogens. Acta Paediatrica Scandinavica, 80(2018-06-07), 596-601.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/564