Two-year duration of immunity of inactivated poliovirus vaccine: A follow-up study in Pakistan in 2020

Authors

Ali Faisal Saleem, Aga Khan UniversityFollow
Sadia Parkar, Aga Khan UniversityFollow
Syeda Mahjabeen Zehra, Aga Khan UniversityFollow
Zaubina Kazi, Aga Khan UniversityFollow
Asma Sadruddin Pethani, Aga Khan UniversityFollow
Yiting Zhang, Centers for Disease Control and Prevention, United States
Bernardo A. Mainou, Centers for Disease Control and Prevention, United States
Rocio Lopez Cavestany, World Health Organization, Switzerland
Grace Macklin, World Health Organization, Switzerland
Visalakshi Jeyaseelan, World Health Organization, Switzerland

Document Type

Article

Department

Paediatrics and Child Health

Abstract

This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies two years post-immunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% one and two years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi. Clinical Trial Registration NCT03286803.

Comments

Volume, issue, and pagination are not provided by the author/publisher.

Publication (Name of Journal)

The Journal of Infectious Diseases

Recommended Citation

Saleem, A., Parkar, S., Zehra, S. M., Kazi, Z., Pethani, A. S., Zhang, Y., Mainou, B. A., Cavestany, R. L., Macklin, G., Jeyaseelan, V. (2023). Two-year duration of immunity of inactivated poliovirus vaccine: A follow-up study in Pakistan in 2020. The Journal of Infectious Diseases.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/1379