Recent advancements in gremlin-1: Breast cancer
Paediatrics and Child Health; General Surgery; Breast Surgery
One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or -independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.
Publication ( Name of Journal)
Journal of the Pakistan Medical Association
(2023). Recent advancements in gremlin-1: Breast cancer. Journal of the Pakistan Medical Association, 73(2), S155-S159.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/1340