Recent advancements in gremlin-1: Breast cancer
Document Type
Review Article
Department
Paediatrics and Child Health; General Surgery; Breast Surgery
Abstract
One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or -independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.
Publication (Name of Journal)
Journal of the Pakistan Medical Association
Recommended Citation
Inam, N.,
Hameed, A.,
Vohra, L.
(2023). Recent advancements in gremlin-1: Breast cancer. Journal of the Pakistan Medical Association, 73(2), S155-S159.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_paediatr/1340