Document Type
Article
Department
Urology; Paediatric Surgery
Abstract
Background: Renal and ureteric stones (RS) can form due to genetic, metabolic, environmental, and diet-hydration related factors. Studies have shown that patients with family history (FH) of RS have higher likelihood of recurrence.
Materials and methods: We conducted a retrospective cross-sectional study on 114 pedigrees to investigate the impact of FH on recurrence of RS and examine patterns of inheritance. Results: Family history of renal stone disease was found in 42% of all patients. There was a significant increase of stone recurrence in RS patients with a positive FH (p=0.001). Seventy-one percent of patients with recurrent stones had at least one family member with RS. Interestingly, male penetrance was higher in RS recurrence, where a greater proportion of males had no FH of RS, indicating that there may be other factors involved as well. Conclusion: Family history in RS patients should be continuously explored for the possible underlying genetic influence, whilst keeping in mind the dietary habits of the family.
Publication ( Name of Journal)
Cureus
Recommended Citation
Biyabani, S.,
Talati, J. J.,
Umer, D.,
Kazmi, Z.,
Soomro, H. U.,
Mansoor, R.
(2021). Analysis of 114 pedigrees of renal stone patients: A retrospective review. Cureus, 13(2), e13464.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_surg_urol/175
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
Pagination are not provided by the author/publisher