Introduction:We report a case of sero-negative celiac disease in Pakistan. Case Presentation: A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms.
Negative serology should not rule out celiac disease, intestinal biopsy should be performed if there is strong clinical suspicion.
Publication ( Name of Journal)
(2009). Sero-negative celiac disease with dermatitis herpetiformes: a case report.. Cases Journal, 2, 7512.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_surg_surg/78