Document Type
Article
Department
Surgery; Orthopaedic Surgery
Abstract
Abstract
OBJECTIVE:
To compare the frequency of blood transfusion after surgery for fixation of inter-trochanteric fractures in patients given tranexamic acid versus placebo.
METHODS:
The randomised control trial was conducted at the Aga khan university hospital from May 1 to October 31, 2014, and comprised patients diagnosed with Inter-trochanteric fracture based on X-ray imaging. The patients were randomised into two equal groups based on a computer-generated random number table. The Intervention group received two doses of 10mg/kg body weight of tranexamic acid just before surgery and three hours later intravenously. The Control group received two doses of 10mg/kg body weight of normal saline at similar intervals. Numbers of blood transfusions required postoperatively were noted based on the postoperative haemoglobin readings.
RESULTS:
There were 100 patients who were divided into groups of 50(50%) each. Mean post-op haemoglobin for the intervention group was 10.2±2.4 g/dl and for the control group it was 8.9±2.4 g/dl (p=0.007). Nine (18%) patients in intervention group required blood transfusion compared to 21(42%) in control group (p=0.009).
CONCLUSIONS:
Administering tranexamic acid was a useful and safe option for reducing requirement of blood transfusion postoperatively after inter-trochanteric hip fracture
Publication (Name of Journal)
JPMA: Journal of the Pakistan Medical Association
Recommended Citation
Mohib, Y.,
Rashid, R.,
Ali, M.,
Zubairi, A.,
umer, m.
(2015). Does tranexamic acid reduce blood transfusion following surgery for inter-trochanteric fracture? a randomized control trial. JPMA: Journal of the Pakistan Medical Association, 65(11), S17-s20.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_surg_surg/240