Congenital diaphragmatic hernia: Searching for answers

Authors

John R. Gosche, University of Mississippi Medical Center, United States
Saleem Islam, University of Mississippi Medical Center, United StatesFollow
Scott C. Boulanger, University of Mississippi Medical Center, United States

Document Type

Article

Department

Paediatric Surgery

Abstract

Background: Pulmonary hypoplasia and hypertension are the primary causes of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). At present, the origin of CDH and the causes of pulmonary hypoplasia and hypertension are unknown.
Data sources: This article reviews the available published data regarding the origin of CDH and the pathogenesis of the associated pulmonary hypertension and hypoplasia. These investigations have employed human tissues as well as two types of CDH animal models.
Conclusions: Investigations performed to date have not yet provided definitive answers regarding the pathogenesis of CDH. However, they have yielded many new and exciting discoveries and several opportunities for intervention. Ongoing research should open new possibilities to improve the outcome for these unfortunate babies with CDH.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

The American Journal of Surgery

Recommended Citation

Gosche, J. R., Islam, S., Boulanger, S. C. (2005). Congenital diaphragmatic hernia: Searching for answers. The American Journal of Surgery, 190(2), 324-332.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_surg_paediatr/179