The current standard of care in glioblastoma management is surgery followed by chemotherapy and radiotherapy. Temozolomide is an alkylating agent most commonly used with a few other second line options. The efficacy of systemic chemotherapy in brain malignancies is limited due to the nature of the blood-brain barrier. Nanomedicine offers one avenue of improving drug delivery to these tumours in a more focussed and effective way in higher doses than currently possible, while simultaneously reducing systemic toxicity.
JPMA. The Journal of the Pakistan Medical Association
Kishwar Jafri, S. K.,
Bukhari, S. S.,
(2021). Nanomedicine in the treatment of glioblastoma. JPMA. The Journal of the Pakistan Medical Association, 71(11), 2678-2680.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_surg_neurosurg/326