Nanomedicine in the treatment of glioblastoma

Authors

Syeda Kubra Kishwar Jafri, Aga Khan University
Syed Sarmad Bukhari, Aga Khan UniversityFollow
Muhammad Shahzad Shamim, Aga Khan UniversityFollow

Document Type

Article

Department

Neurosurgery

Abstract

The current standard of care in glioblastoma management is surgery followed by chemotherapy and radiotherapy. Temozolomide is an alkylating agent most commonly used with a few other second line options. The efficacy of systemic chemotherapy in brain malignancies is limited due to the nature of the blood-brain barrier. Nanomedicine offers one avenue of improving drug delivery to these tumours in a more focussed and effective way in higher doses than currently possible, while simultaneously reducing systemic toxicity.

Publication (Name of Journal)

JPMA. The Journal of the Pakistan Medical Association

Recommended Citation

Kishwar Jafri, S. K., Bukhari, S. S., Shamim, M. (2021). Nanomedicine in the treatment of glioblastoma. JPMA. The Journal of the Pakistan Medical Association, 71(11), 2678-2680.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_surg_neurosurg/326