Predictors of poor quality of life after primary lower limb deep venous thrombosis: A perspective from a developing nation

Nadeem Ahmed Siddiqui, Aga Khan University
Asad Moosa, Aga Khan University
Fareed A. Shaikh, Aga Khan University
Noman Shahzad, Northern Lincolnshire and Goole NHS Foundation Trust, Scunthorpe, United Kingdom
Shahid Nazir, Aga Khan University
Ziad Sophie, Aga Khan University


Objective: We aimed to determine predictors of poor long term quality of life, using the VEINES Quality of Life (QOL) questionnaire, in patients with lower limb deep venous thrombosis (DVT).
Material and Methods: This study included adult patients with primary lower limb DVT between January 2007 and December 2017. Post thrombotic syndrome (PTS) was assessed using the Villalta score and Quality of Life (QoL) by the VEINES quality of life questionnaire.
Results: Our study included 125 patients, 57 (45.6%) of whom were males. The patient population's median age was 41 years (IQR: 34-47 years). The median follow up was 450 days (IQR: 390-1020 days). PTS occurred in 49 (39.2%) patients. Independent predictors of poor quality of life post DVT were progression to PTS, complete occlusion of vein, proximal (Ileofemoral) DVT, poor control of INR, poor compliance with compression stockings, severity of PTS, ileofemoral DVT and poor control of therapeutic anticoagulation.
Conclusion: Predictors who are independently associated with poor quality of life post DVT are PTS, inability to maintain therapeutic anticoagulation and ileofemoral DVT.