United States trends in thrombolysis for older adults with acute ischemic stroke

Document Type



General Surgery


Objective: Thrombolysis for ischemic stroke has been increasing in the United States. We sought to investigate recent trends in thrombolysis use in older adults.
Methods: A retrospective, observational analysis of hospitalization data from the Nationwide Inpatient Sample (NIS) in 2005-2010 was performed. Older adults (≥65 years) admitted with a primary diagnosis of acute ischemic stroke were included. Trends in the population-based rates of thrombolysis and outcomes from the NIS were evaluated using the Cochran-Armitage test.
Results: Thrombolysis in older adult stroke patients increased from 1.7% to 5.4% (2005-2010; trend PConclusions: Rates of thrombolysis in older adults progressively increased, especially in the oldest old. Increases were largely driven by urban and high volume hospitals.


This work was published before the author joined Aga Khan University

Publication (Name of Journal)

Clinical Neurology and Neurosurgery