Breast cancer and diabetes mellitus-related mortality among U.S. adults: A 25-year CDC WONDER analysis (1999-2023)

Document Type

Article

Department

Surgery; Breast Surgery

Abstract

Background: Breast cancer (BC) and diabetes mellitus (DM) frequently coexist, posing significant clinical challenges. Evaluating long-term mortality trends helps assess the impact of healthcare practices and public health policies. This study examines mortality trends involving breast cancer and DM in US adults aged > 25, stratified by demographics and geography.
Methods: We conducted a retrospective analysis of CDC WONDER mortality data from 1999 to 2023 for individuals aged ≥ 25 years. BC and DM were identified using ICD-10 codes C50 and E10-E14. Age-adjusted mortality rates (AAMR) per 100,000 were calculated. Joinpoint regression estimated annual percentage changes (APC) with 95% confidence intervals (CI).
Results: From 1999 to 2023, 79,139 deaths involving BC and DM. Overall, AAMR remained stable (AAPC 0.23; 95% CI, -0.002 to 0.475, p > 0.05). Females had higher AAMR (2.42) than males (0.05). Non-Hispanic (NH) Blacks had the highest AAMR (2.69), followed by Hispanics (1.31), NH Whites (1.28). Older adults, rural residents, and the Midwest region had higher mortality.
Conclusion: Mortality involving BC and DM has remained largely stable over two decades, but disparities by sex, age, race/ethnicity, and geography persist, highlighting the need for targeted interventions in high-risk populations.

Publication (Name of Journal)

Journal of Diabetes & Metabolic Disorders

DOI

10.1007/s40200-026-02074-4

Link to Full Text

Share

COinS