Drug-induced movement disorder and confusion associated with duloxetine

Authors

Sarah Hasan Siddiqui., Aga Khan University
Nadeem Ahmed Memon, Aga Khan University
Ravi Shanker, Aga Khan University

Document Type

Report

Department

Neurology

Abstract

A 60-year-old woman with major depressive disorder, developed high blood pressure, confusion and dyskinesias of face, neck and jaw, following an increase in her dose of duloxetine. Routine blood tests including toxic, infective and metabolic workup were unremarkable. Cerebrospinal fluid analysis and electroencephalogram were also normal. MRI brain showed bilaterally symmetrical diffusion-restricted areas in deep cerebral white matter. Duloxetine was held on suspicion of drug adverse effect. She had complete resolution of symptoms within 48 hours and resolution of MRI brain changes over 6 weeks. Serotonin norepinephrine reuptake inhibitors such as duloxetine may have the potential to cause drug-induced movement disorders, confusion and high blood pressure and should be used cautiously especially in elderly.

Comments

Case report.

Abstract/Volume,issue and pagination are not provided by the Publisher.

Publication (Name of Journal)

BMJ case reports.

Recommended Citation

Siddiqui., S. H., Memon, N. A., Shanker, R. (2018). Drug-induced movement disorder and confusion associated with duloxetine. BMJ case reports..
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_neurol/123