The severity of acute viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency: A case-control study

Document Type

Article

Department

Medicine

Abstract

Objective: To compare outcomes and severity parameters in patients with acute viral hepatitis and those with acute viral hepatitis and glucose-6-phosphate dehydrogenase deficiency.
Methods: The retrospective, case-control study was conducted at Aga Khan University Hospital, Karachi, and comprised data from June 1, 2016, to January 31, 2022, related to patients with acute viral hepatitis having glucose 6-phosphate dehydrogenase deficiency in group A, and patients with acute viral hepatitis without G6PD deficiency in control group B. Data was analysed using SPSS 19.
Results: Of the 27 male patients, 9 (33.3%) were in group A, with a mean age of 28.89 ± 6.7 years, while group B had 18 (66.6%) patients, with a mean age of 28.11 ± 8.6 years. There was no female subject in the sample. The haemoglobin levels were lower in group A patients (p=0.06). Total bilirubin, direct bilirubin, serum creatinine, and the length of hospital stay were significantly different between the groups (p< 0.05).
Conclusions: Acute hepatitis in patients with G6PD deficiency may present with a more severe course complicated by haemolysis, hyperbilirubinaemia, acute liver failure, and acute kidney injury. Early recognition of G6PD deficiency is essential for appropriate monitoring and prevention of complications.

Publication (Name of Journal)

J Pak Med Assoc

DOI

10.47391/JPMA.21107

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