Impact of multiplex PCR blood-culture identification panels on clinical outcomes, antimicrobial stewardship, and economic impact in US hospitals: A systematic review and meta-analysis
Document Type
Review Article
Department
Medicine
Abstract
Background: We performed a systematic review and meta-analysis synthesizing evidence on multiplex PCR blood culture identification (BCID) panels and their effects on clinical, antimicrobial stewardship, and economic outcomes.
Methods: We searched PubMed, Scopus, Embase, CINAHL, Web of Science, and the Cochrane Library for studies evaluating time to appropriate therapy, mortality, length of stay (LOS), antimicrobial optimization, and cost in adult inpatients.
Results: Twenty studies encompassing 4587 patients with bloodstream infections across U.S. hospitals were included. BCID implementation showed shorter time to appropriate antimicrobial therapy by 17.28 hours (95% CI, -24.00 to -10.56) and hospital LOS by 1.25 days (95% CI, -1.79 to -.71). No statistically significant effect on mortality was observed (OR, 1.04; 95% CI, .81-1.34). Economic outcomes were not significantly different.
Conclusions: BCID panels were associated with shorter time to effective therapy; however, a timely clinical response is necessary.
Publication (Name of Journal)
Open Forum Infect Dis
DOI
10.1093/ofid/ofag370
Recommended Citation
Muqtadir, J.,
Bhatti, S.,
Batool, I.,
Lesho, E. P.
(2026). Impact of multiplex PCR blood-culture identification panels on clinical outcomes, antimicrobial stewardship, and economic impact in US hospitals: A systematic review and meta-analysis. Open Forum Infect Dis, 13(7), 1-10.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_med_med/804