Angiography-derived physiology versus pressure wire-based fractional flow reserve for coronary revascularization guidance: A systematic review and meta-analysis

Authors

• Mokshit Mehul Shah, GMERS Medical College and Hospital, India
• Sarosh Fatima, Dow Medical College, Pakistan
• Mariam Khachatryan, Fanarjyan Clinic, Armenia
• Igwilo Chukwudumebi Angela, College of Medicine, Nigeria
• Umair Arshad, Services Institute of Medical Sciences, Pakistan
• Mirzar Muhammad Hadeed Khawar, Services Institute of Medical Sciences, Pakistan
• Jahnoy St Jacques, University of the West Indies, Jamaica
• Naima Agha, Foundation University Medical College, Pakistan
• Hamza Hashmi, Aga Khan University
• Bigenimana Adimirabilis Malombe, Catholic University of Health and Allied Science (CUHAS)-Bugando, Tanzania
• Zeeshan Ayaz, Khyber Medical University, Pakistan
• Muneeb Khawar, King Edward Medical University, Pakistan

Document Type

Article

Department

Medicine

Abstract

Pressure-wire-based fractional flow reserve (FFR) is the gold standard for physiological assessment of intermediate coronary stenoses but remains underutilized owing to procedural complexity, cost, and the need for hyperemic agents. Angiography-derived physiology (ADP) platforms offer a wire-free, adenosine-free alternative. This systematic review and meta-analysis compared the clinical outcomes of ADP-guided versus FFR-guided revascularization in patients with coronary artery disease.

Comments

Issue no. was not provided by author/publisher.

Publication (Name of Journal)

JRSM cardiovascular disease

DOI

10.1177/20480040261469414

Recommended Citation

Shah, M. M., Fatima, S., Khachatryan, M., Angela, I. C., Arshad, U., Khawar, M. M., Jacques, J. S., Agha, N., Hashmi, H., Malombe, B. A., Ayaz, Z., Khawar, M. (2026). Angiography-derived physiology versus pressure wire-based fractional flow reserve for coronary revascularization guidance: A systematic review and meta-analysis. JRSM cardiovascular disease, 15(-), 1-13.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_med/798