Implementation of a goal-directed care bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial

Authors

• Menglu Ouyang, University of New South Wales, Sydney, Australia
• Anila Anjum, Aga Khan UniversityFollow
• Francisca Gonzalez Mc Cawley, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Chile
• Mohammad Wasay, Aga Khan UniversityFollow
• Lu Ma, West China Hospital, Sichuan University, Chengdu, China
• Xin Hu, West China Hospital, Sichuan University, Chengdu, China
• Xiaoying Chen, University of New South Wales, Sydney, Australia
• Alejandra Malavera, University of New South Wales, Sydney, Australia
• Xi Li, West China Hospital, Sichuan University, Chengdu, China
• Paula Muñoz Venturelli, University of New South Wales, Sydney, Australia
• H Asita de Silva, University of Kelaniya, Kelaniya, Sri Lanka
• Nguyen Huy Thang, Stroke Unit, 115 Hospital, Ho Chi Minh City, Vietnam
• Kolawole W. Wahab, University of Ilorin & University of Ilorin Teaching Hospital, Ilorin, Nigeria
• Jeyaraj D. Pandian, Christian Medical College and Hospital, Ludhiana, India
• Octavio M. Pontes-Neto, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
• Carlos Abanto, National Institute of Neurological Sciences, Lima, Peru
• Venessa Cano- Nigenda, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Mexico City, Mexico
• Antonio Arauz, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Mexico City, Mexico
• Chao You, West China Hospital, Sichuan University, Chengdu, Chin
• Stephen Jan, Faculty of Medicine, University of New South Wales, Sydney, Australia

Document Type

Article

Department

Medicine; Neurology

Abstract

The third, stepped-wedge, cluster-randomized, Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3), has shown that a goal-directed multi-faceted Care Bundle incorporating protocols for the management of physiological variables was safe and effective for improving functional recovery in a broad range of patients with acute intracerebral hemorrhage (ICH). The INTERACT3 Care Bundle included time- and target-based protocols for the management of early intensive lowering of systolic blood pressure (SBP, targetNCT03209258) and the Chinese Clinical Trial Registry (ChiCTR-IOC-17011787).

Publication (Name of Journal)

PLOS Global Public Health

DOI

10.1371/journal.pgph.0003711

Recommended Citation

Ouyang, M., Anjum, A., Mc Cawley, F. G., Wasay, M., Ma, L., Hu, X., Chen, X., Malavera, A., Li, X., Venturelli, P. M., Silva, H. d., Thang, N. H., Wahab, K. W., Pandian, J. D., Pontes-Neto, O. M., Abanto, C., Nigenda, V. C., Arauz, A., You, C., Jan, S. (2024). Implementation of a goal-directed care bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial. PLOS Global Public Health, 4(12), 1-14.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_med/729