GRADE-ADOLOPMENT of clinical practice guideline for postmenopausal osteoporosis management—A Pakistani context

Authors

Sarah Nadeem, Aga Khan UniversityFollow
Alina Pervez, Aga Khan UniversityFollow
Muhammad Abbas Abid, Aga Khan UniversityFollow
Rehab Naeem Khalid, Aga Khan UniversityFollow
Nashia Ali Rizvi, Aga Khan UniversityFollow
Salima Saleem Aamdani, Aga Khan UniversityFollow
Mohsin Ali Mustafa, Aga Khan UniversityFollow
Sibtain Ahmed, Aga Khan UniversityFollow
Mehmood Riaz, Aga Khan UniversityFollow
Shahryar Noordin, Aga Khan UniversityFollow
Lena Jafri, Aga Khan UniversityFollow
Hafsa Majid, Aga Khan UniversityFollow
Masood Umer, Aga Khan UniversityFollow
Nawazish Zehra, Aga Khan UniversityFollow
Aisha Sheikh, Aga Khan UniversityFollow
Adil H. Haider, Aga Khan UniversityFollow
Aysha Habib, Aga Khan UniversityFollow

Document Type

Article

Department

Diabetes/Endocrinology and Metabolism; Medical College Pakistan; Pathology and Laboratory Medicine; Medicine; Surgery; General Surgery

Abstract

Due to its high prevalence, we aimed to create postmenopausal osteoporosis clinical practice guideline via GRADE-ADOLOPMENT for Pakistan. We recommend a higher dose (2000-4000 IU) of vitamin D for osteoporotic patients who are old, have malabsorption, or are obese. The guideline will help standardize care provision and improve health care outcomes for osteoporosis.
Purpose: Postmenopausal osteoporosis affects one in every five postmenopausal women in Pakistan. An evidence-based clinical practice guideline (CPG) is needed to standardize care provision to optimize health outcomes. Hence, we aimed to develop CPG for the management of postmenopausal osteoporosis in Pakistan.
Methods: The GRADE-ADOLOPMENT process was used to adopt (as is or with minor changes), exclude (omit), or adapt (modify based on local context) recommendations to the source guideline (SG)-clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update from American Association of Clinical Endocrinology (AACE).
Results: The SG was "adoloped" to cater to the local context. The SG consisted of 51 recommendations. Forty-five recommendations were adopted as is. Due to unavailability of drugs, 4 recommendations were adopted with minor changes, and one was excluded, while one recommendation was adopted with the inclusion of use of a surrogate FRAX tool specific for Pakistan. One recommendation regarding vitamin D dosage was adapted to recommend a dose of 2000-4000 IU of vitamin D in patients with obesity, malabsorption, and old age.
Conclusion: The developed Pakistani postmenopausal osteoporosis guideline consists of 50 recommendations. The guideline created recommends a higher dose (2000-4000 IU) of vitamin D for patients who are old, have malabsorption, or are obese, which is an adaptation from the SG by the AACE. This higher dose is justified as lower doses prove to be suboptimal in these groups and should be complemented with baseline vitamin D and calcium levels.

Comments

Pagination are not provided by the author/publisher.

Publication (Name of Journal)

Archives of Osteoporosis

Recommended Citation

Nadeem, S., Pervez, A., Abid, M. A., Khalid, R. N., Rizvi, N. A., Aamdani, S. S., Mustafa, M. A., Ahmed, S., Riaz, M., Noordin, S., Jafri, L., Majid, H., Umer, M., Zehra, N., Sheikh, A., Haider, A. H., Habib, A. (2023). GRADE-ADOLOPMENT of clinical practice guideline for postmenopausal osteoporosis management—A Pakistani context. Archives of Osteoporosis, 18(71).
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_diabet_endocrinol_metab/116