Frequency and risk factors of permanent hypoparathyroidism after total thyroidectomy: An experience at a tertiary care hospital in Pakistan

Authors

Anum Naushad, Aga Khan University
Sadia Sattar, Aga Khan University
Muhammad SalikFollow
Maria Wajid, Aga Khan UniversityFollow
Farah Khalid, Aga Khan UniversityFollow
Ali Shabbir Hussain, Aga Khan UniversityFollow
Moghira Siddiqui, Aga Khan UniversityFollow
Qamar Masood, Aga Khan UniversityFollow

Document Type

Article

Department

Medicine; Diabetes/Endocrinology and Metabolism; Paediatrics and Child Health; Surgery

Abstract

Objectives: Thyroid surgeries are among the most common operations performed in the world. Hypocalcemia following total thyroidectomy (TT) is a common complication that is sometimes difficult to correct. This study aims to determine the frequency of hypocalcemia and permanent hypoparathyroidism (PtHPT) following TT.
Methods: A total of 363 patient records were reviewed who underwent TT for any reason. Thirty-eight patients did not have a follow-up in the clinic in the postoperative period and were excluded from the final analysis with the final sample as 325. For patients who developed hypocalcemia during the postoperative hospital stay, their lowest calcium levels were recorded and medical records were reviewed for the period of one year for the requirement of oral calcium and active form of vitamin D (calcitriol or alpha calcidiol) in the outpatient setting. Patients who required calcium and vitamin D supplementation for up to 1 year were labeled as having PtHPT. Risk factors were analyzed among those who developed PtHPT.
Results: From a total of 325 patients postoperative hypocalcemia developed in 163 (50.2%) patients, and 162 (49.8%) patients remained normocalcemic. Permanent hypoparathyroidism was found in 42(12.9%) patients and transient HPT in 121 (37.2%). Age, severe postoperative hypocalcemia (PoHC), and readmission for hypocalcemia were independent risk factors for PtHPT.
Conclusions: Transient hypoparathyroidism (THPT) is common in our setup. Patients who develop severe hypocalcemia postoperatively and need readmission should be closely followed for the development of PtHPT.

Comments

Volume, issue, and pagination are not provided by the author/publisher.

Publication (Name of Journal)

Ear, Nose, & Throat Journal

Recommended Citation

Naushad, A., Sattar, S., Salik, M., Wajid, M., Khalid, F., Hussain, A. S., Siddiqui, M., Masood, Q. (2023). Frequency and risk factors of permanent hypoparathyroidism after total thyroidectomy: An experience at a tertiary care hospital in Pakistan. Ear, Nose, & Throat Journal.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_med_diabet_endocrinol_metab/115