Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings

Authors

Usman Ahmed, University of Alberta, Canada
Jeremy Soo, University of Alberta, Canada
Andrea Conroy, Indiana University School of Medicine,USA
Sophie Namasopo, Kabale District Hospital, Kenya
Robert Opoka, Aga Khan UniversityFollow
Ravi Bhargava, University of Alberta, Canada
Michael Hawkes, University of Alberta, Canada

Document Type

Article

Department

Paediatrics and Child Health (East Africa)

Abstract

In a prospective cohort study of 77 children with severe pneumonia from two hospitals in Uganda, we assessed soluble T cell immunoglobulin and mucin-domain containing protein 3 (sTIM-3) levels at hospital admission and their association with pneumonia severity and subsequent mortality. sTIM-3 levels were positively correlated with the Respiratory Index of Severity in Children (RISC) (ρ = 0.35, p = 0.0017), sTIM-3 levels were higher in children who required transfer to a tertiary hospital (p = 0.014) and in fatal cases (p = 0.011). In summary, sTIM-3 is associated with disease severity and predictive of mortality in childhood pneumonia in resource-limited settings.

Comments

This work was published before the author joined Aga Khan University.

Recommended Citation

Ahmed, U., Soo, J., Conroy, A., Namasopo, S., Opoka, R., Bhargava, R., Hawkes, M. (2022). Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/290