Neurocognitive impairment in Ugandan children with sickle cell anemia compared to non-sickle siblings
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
Purpose: Sickle cell anemia (SCA) increases childhood risk of neurocognitive impairment from severe anemia and vascular brain injury. We hypothesized that impaired neurocognitive function was more prevalent in Ugandan children with SCA than in their non-SCA siblings. Materials and methods: In the BRAIN SAFE 1 cross-sectional study (Green NS, 2019), a sample of children ages 1-12 years were randomly selected from Mulago Hospital SCA clinic in Kampala. Their neurocognitive function was compared to that of unaffected siblings using age-appropriate tests: Mullen Scales of Early Learning (Mullen) for children under age five and Kaufman Assessment Battery for Children, second edition (KABC-II) for ages 5-12. Raw scores were converted into age-adjusted Z-scores compared to established community controls; Z-scores-2 or lower were categorized as impaired neurocognitive function.
Publication (Name of Journal)
HemaSphere
Recommended Citation
Bangirana, P.,
Idro, R.,
Opoka, R.,
Munube, D.,
Mupere, E.,
Kasyire, P.,
Green, N.,
Boehme, A.
(2022). Neurocognitive impairment in Ugandan children with sickle cell anemia compared to non-sickle siblings. HemaSphere, 6, 05-06.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/257
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
This work was published before the author joined Aga Khan University.