AMPATH Oncology: Baseline HPV detection in Kenyan women enrolled in a longitudinal study of modifiable factors predicting cervical dysplasia.

Document Type

Article

Department

Obstetrics and Gynaecology (East Africa)

Abstract

Background: Cervical cancer is caused by oncogenic HPV types. Kenyan women, HIV-infected or uninfected were studied to define modifiable factors predicting incidence and persistence of HPV and cervical dysplasia.

Methods: From 9/21/2015 to 10/4/2016, 223 women ages 18 to 45 years old with normal VIA at enrollment were enrolled in a longitudinal study in Kenya. Cervical swabs, behavioral data, and other data were collected. HPV typing was performed on clinician-obtained cervical swabs using the Roche Linear Array.

Results: Analysis of 219 evaluable participants was done, including 115 HIV-infected (median age 36 years) and 104 HIV-uninfected women (median age 33 years) (p = .0009). Among HIV-infected women, 86.8% were receiving anti-retroviral therapy (ART); median duration between HIV diagnosis and enrollment was 7.2 years (IQR 4.1-10.3); median CD4 count was 471 (IQR 310-612). There was a significant difference in number of lifetime sex partners between HIV-infected (median 4, IQR 3-8) and HIV-uninfected women (median 3, IQR 1.5-4), p = .0001. HPV detection is shown in Table 1.

Conclusions: Oncogenic HPV types, including types preventable by vaccination were prevalent in Kenyan women. HIV-infected women were more likely to have detection of HPV 16, other oncogenic HPV types, and multiple types in spite of ART. In this longitudinal study, other factors will be included such as behaviors, the effect of HIV viral load, CD4 count, and details of ART.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Journal of Clinical Oncology

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