Detection of types of HPV among HIV-infected and HIV-uninfected Kenyan women undergoing cryotherapy or loop electrosurgical excision procedure

Authors

Elkanah Omenge, Aga Khan UniversityFollow
Jordan P. Emont, Brown University, USA
Aaron Ermel, Indiana University, USA
Tao Liu, Brown University, USA
Victor Omodi, Moi University, Kenya
Yan Tong, Indiana University School of Medicine, USA
Peter Itsura, Moi University, Kenya
Philip Tonui, Moi University, Kenya.
Titus Maina, Maseno University, Kenya
John M. Ong’echa, Kenya Medical Research Institute, Kenya

Document Type

Article

Department

Obstetrics and Gynaecology (East Africa)

Abstract

Objective: To assess the baseline types of HPV infection among HIV-positive and HIV-negative women in western Kenya undergoing cryotherapy or loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia.

Methods: A prospective observational study was conducted of baseline HPV characteristics of women undergoing visual inspection with acetic acid (VIA) and cryotherapy or LEEP. After a positive VIA in HIV-positive and HIV-negative women, data on demographics, CD4 count, and use of antiretroviral therapy and a cervical swab were collected. HPV typing was performed using the Roche Linear Array.

Results: Of 175 participants, 86 (49.1%) were HIV-positive and had a higher prevalence of low-risk HPV types (odds ratio [OR] 5.28, P=0.005) compared with HIV-negative women. The most common high-risk (HR)-HPV types in HIV-positive women were HPV 16 (13.9%) and HPV 18 (11.1%). HIV-positive women requiring LEEP were more likely to have HR-HPV types (OR 6.67, P=0.012) and to be infected with multiple HR-HPV types (OR 7.79, P=0.024) compared to those undergoing cryotherapy.

Conclusion: HIV-positive women requiring LEEP versus cryotherapy had a higher prevalence of any HR-HPV type and multiple HR-HPV types. There were no such differences in HPV types identified among HIV-negative women.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

International Journal of Gynecology & Obstetrics

DOI

https://doi.org/10.1002/ijgo.13330

Recommended Citation

Omenge, E., Emont, J. P., Ermel, A., Liu, T., Omodi, V., Tong, Y., Itsura, P., Tonui, P., Maina, T., Ong’echa, J. M. (2020). Detection of types of HPV among HIV-infected and HIV-uninfected Kenyan women undergoing cryotherapy or loop electrosurgical excision procedure. International Journal of Gynecology & Obstetrics, 151(2), 279-286.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_obstet_gynaecol/660

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.