An aggressive presentation of anti-melanoma differentiation-associated gene 5 (MDA-5)-positive dermatomyositis with rapidly progressive interstitial lung disease: A case report

Authors

• Zamanali Khakhar, University of Nairobi, Kenya
• Shreedhi Patel, University of Nairobi, Kenya
• Rajiv Patel, Aga Khan UniversityFollow
• Soraiya Manji, Aga Khan UniversityFollow
• Fredrick Otieno, Aga Khan UniversityFollow
• Sayed Karar, Aga Khan UniversityFollow

Document Type

Article

Department

Internal Medicine (East Africa)

Abstract

Anti-melanoma differentiation-associated gene 5 (MDA-5) dermatomyositis is an uncommon condition that is frequently complicated by rapidly progressive interstitial lung disease (RP-ILD), resulting in a poor prognosis. Due to its aggressive course, management is often challenging and requires timely interventions to improve outcomes. This case of a female patient with anti-MDA-5-positive DM and RP-ILD aims to document this unique and uncommon condition, its aggressive clinical course, associated complications, diagnostic challenges, and management considerations.

Publication (Name of Journal)

Cureus

DOI

https://doi.org/10.7759/cureus.111003

Recommended Citation

Khakhar, Z., Patel, S., Patel, R., Manji, S., Otieno, F., Karar, S. (2026). An aggressive presentation of anti-melanoma differentiation-associated gene 5 (MDA-5)-positive dermatomyositis with rapidly progressive interstitial lung disease: A case report. Cureus, 18(6), 1-6.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_intern_med/609

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.