Long-term clinical outcomes of adults hospitalized for Covid-19 Pneumonia
Document Type
Article
Department
Internal Medicine (East Africa)
Abstract
We conducted a multicenter, observational, 12-month follow-up study to identify the extended health burden of severe COVID-19 pneumonia by characterizing long-term sequelae of acute infection in participants previously enrolled in clinical trials for severe COVID-19 pneumonia requiring hospitalization. Overall, 134 (77.5%) of 173 participants completed the study. At 12 months, 51 (29.5%) participants reported cough, 60 (34.7%) reported dyspnea, 56 (32.4%) had residual lung texture abnormalities on high-resolution computed tomography scans, 26 (15.0%) had impaired forced vital capacity, 52 (30.1%) had cognitive impairment, and 77 (44.5%) reported fatigue. Disease severity during acute infection and age were associated with persistent lung texture abnormalities; history of hypertension was associated with higher prevalence of fatigue and more frequent dyspnea and cough; and age and obesity were associated with long-term cognitive impairment. Our findings underscore the long-term health burden of severe COVID-19 pneumonia, reinforcing the importance of regular monitoring in older persons and those with underlying illnesses.
Publication (Name of Journal)
Emerging Infectious Diseases
DOI
https://doi.org/10.3201/eid3106.241097
Recommended Citation
Rosas, I.,
Benitez, A.,
McKinnell, J.,
Shah, R.,
Waters, M.,
Hunter, B.,
Jeanfreau, R.,
Tsai, L.,
Neighbors, M.,
Trzaskoma, B.
(2025). Long-term clinical outcomes of adults hospitalized for Covid-19 Pneumonia. Emerging Infectious Diseases, 31(6).
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_intern_med/474