Document Type
Article
Department
Haematology and Oncology, East Africa
Abstract
We studied the efficiency of a standard-kit preparation using 1 mg 111In-labeled 96.5 monoclonal antibody in combination with 19 mg of unlabeled antibody in the diagnostic imaging of 27 patients with documented metastatic melanoma. Twenty-three of 26 patients (88%) demonstrated immunoscintigraphic localization of tumor. Of 104 metastatic sites previously documented by conventional studies, 62 (60%) were identified by immunoscintigraphy. A total of 77 sites demonstrated localization of radiolabeled antibody. Fifty-four (70%) corresponded to known sites of disease; eight sites (10%) were "discovered" by immunoscintigraphy and subsequently confirmed by conventional studies; 15 imaged sites (20%) could not be confirmed by conventional studies. Size and location of metastasis appear to be important features that influence imaging efficiency. Tumor size (greater than or equal to 2 cm v less than 2 cm) appears to be the statistical dominant determinant. The feasibility and potential clinical use of radioimmune imaging of tumors is discussed.
Publication (Name of Journal)
Journal of Clinical Oncology
DOI
https://doi.org/10.1200/JCO.1988.6.6.1059
Recommended Citation
Saleh, M.,
Miller, D. M.,
Peterson, L.,
Russell, C. D.,
Unger, M. W.
(1988). Clinical use of a standard kit-preparation of radiolabeled monoclonal antibody 96.5 in the diagnostic imaging of metastatic melanoma.. Journal of Clinical Oncology, 6(6), 1059-1065.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_haematol_oncol/146
Comments
This work was published before the author joined Aga Khan University.