Brugada Syndrome

Document Type

Book Chapter

AKU Student

no

Publication (Name of Journal)

StatPearls [Internet]

Department

Medicine

Publisher

StatPearls Publishing

Abstract

Brugada syndrome is a rare, potentially life-threatening inherited cardiac disorder that predisposes primarily young, otherwise healthy individuals to fatal ventricular arrhythmias and sudden cardiac death. The condition is most commonly caused by autosomal dominant mutations in the SCN5A gene, which encodes a cardiac sodium channel, although other genetic and environmental factors may modulate disease expression. These mutations impair sodium current, creating conduction abnormalities and predisposing to reentrant arrhythmias.
Clinical manifestations range from asymptomatic electrocardiographic abnormalities to syncope, nocturnal agonal respiration, or sudden cardiac arrest. Diagnosis relies on characteristic electrocardiographic findings, including right bundle branch block and ST-segment elevations in the right precordial leads (V1-V3), sometimes unmasked by fever or pharmacologic challenge. Management focuses on prevention of sudden death, primarily via implantable cardioverter-defibrillator placement, with adjunctive pharmacologic and lifestyle strategies in selected cases. Complications include recurrent ventricular arrhythmias and sudden cardiac death, and prognosis varies with risk stratification, early diagnosis, and adherence to recommended therapy.
This activity for healthcare professionals is designed to sharpen learners' skills in evaluating and managing Brugada syndrome. Participants will improve their understanding of the condition's etiology, risk factors, pathophysiology, clinical presentation, potential complications, and evidence-based diagnostic and therapeutic approaches. Greater proficiency will equip clinicians to collaborate successfully with interprofessional teams caring for individuals with Brugada syndrome.

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