Book Chapter or Conference Paper Title
Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyathea nilgiriensis (Holttum)
Book Title or Conference Proceedings Title
Drug Development for Cancer and Diabetes: A Path to 2030
Pathology (East Africa)
K. Saravanan, Chukwuebuka Egbuna, Horne Iona Averal, S. Kannan, S. Elavarasi, Bir Bahadur
In the present study, phytochemical, and bioactive compounds were identified in the ethylacetate extract of Cyathea nilgiriensis pith powder. Phyto-chemical studies showed the presence of flavonoids, alkaloids, glycosides, carbohydrate, phenols, and steroids. Totally four bioactive compounds were identified by GC-MS analysis. Among the 4 compounds, 1,2-Benzenedicarboxylic acid, butyl 2-ethylhexyl ester was selected as ligand. Molecular docking of ligand with diabetic target (protein tyrosine phosphatase 1 beta) was performed by autodock ver. 4.2.1. The ligand, 1,2-Benzenedicarboxylic acid butyl 2-ethyl hexyl ester was strongly bound with target protein tyro-sine phosphatase 1 beta. From the result, it is concluded that the bioactive compound 1,2-benzene dicarboxylic 2 ethyl hexyl ester may be used as the drug candidate for the treatment of diabetes mellitus after clinical validation.
(2020). Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyathea nilgiriensis (Holttum). Drug Development for Cancer and Diabetes: A Path to 2030, 293-303.
Available at: https://ecommons.aku.edu/book_chapters/345