Book Chapter or Conference Paper Title

Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyathea nilgiriensis (Holttum)

Document Type

Book Chapter

Book Title or Conference Proceedings Title

Drug Development for Cancer and Diabetes: A Path to 2030

Department

Pathology (East Africa)

Edition

1st Edition

ISBN

9780429330490

Editor

K. Saravanan, Chukwuebuka Egbuna, Horne Iona Averal, S. Kannan, S. Elavarasi, Bir Bahadur

Publisher

CRC Press

City

New York

Abstract

In the present study, phytochemical, and bioactive compounds were identified in the ethylacetate extract of Cyathea nilgiriensis pith powder. Phyto-chemical studies showed the presence of flavonoids, alkaloids, glycosides, carbohydrate, phenols, and steroids. Totally four bioactive compounds were identified by GC-MS analysis. Among the 4 compounds, 1,2-Benzenedicarboxylic acid, butyl 2-ethylhexyl ester was selected as ligand. Molecular docking of ligand with diabetic target (protein tyrosine phosphatase 1 beta) was performed by autodock ver. 4.2.1. The ligand, 1,2-Benzenedicarboxylic acid butyl 2-ethyl hexyl ester was strongly bound with target protein tyro-sine phosphatase 1 beta. From the result, it is concluded that the bioactive compound 1,2-benzene dicarboxylic 2 ethyl hexyl ester may be used as the drug candidate for the treatment of diabetes mellitus after clinical validation.

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