Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyathea nilgiriensis (Holttum)
Document Type
Book Chapter
Edition
1st Edition
ISBN
9780429330490
Editor
K. Saravanan, Chukwuebuka Egbuna, Horne Iona Averal, S. Kannan, S. Elavarasi, Bir Bahadur
Publication (Name of Journal)
Drug Development for Cancer and Diabetes: A Path to 2030
Department
Pathology (East Africa)
Publisher
CRC Press
City
New York
Abstract
In the present study, phytochemical, and bioactive compounds were identified in the ethylacetate extract of Cyathea nilgiriensis pith powder. Phyto-chemical studies showed the presence of flavonoids, alkaloids, glycosides, carbohydrate, phenols, and steroids. Totally four bioactive compounds were identified by GC-MS analysis. Among the 4 compounds, 1,2-Benzenedicarboxylic acid, butyl 2-ethylhexyl ester was selected as ligand. Molecular docking of ligand with diabetic target (protein tyrosine phosphatase 1 beta) was performed by autodock ver. 4.2.1. The ligand, 1,2-Benzenedicarboxylic acid butyl 2-ethyl hexyl ester was strongly bound with target protein tyro-sine phosphatase 1 beta. From the result, it is concluded that the bioactive compound 1,2-benzene dicarboxylic 2 ethyl hexyl ester may be used as the drug candidate for the treatment of diabetes mellitus after clinical validation.
Recommended Citation
Elavarasi, S.,
Revathi, G.,
Saravanan, K.
(2020). Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyathea nilgiriensis (Holttum). Drug Development for Cancer and Diabetes: A Path to 2030, 293-303.
Available at:
https://ecommons.aku.edu/book_chapters/345