Document Type

Article

Department

Brain and Mind Institute

Abstract

Background: Dementia research accounts for only 0.1% of all research in Africa,making it the lowest among all low- and middle-income country (LMIC) regions. Thedevelopment and adaptation of biological and psychosocial measures in ethnicallyand culturally diverse populations remain limited but are essential for culturallyinformed research. This is particularly critical for examining sex- and gender-basedvulnerabilities to Alzheimer’s disease and related dementias (ADRD), including factorssuch as reproductive health and fertility.

Method: We conducted a thorough review of our clinical and health questionnaires forcultural relevance and sensitivity through a series (n = 3) of focus groups discussions.These focus groups included a diverse range of participants, such as expert clinicaland academic stakeholders, local community members, health promoters, communityleaders, and representatives, ensuring a well-rounded and inclusive approach.

Result: Certain questions about sexual behavior, sexually transmitted diseases,biological and adopted children, and fertility were deemed culturally inappropriate andrequired rephrasing for sensitivity. To build rapport, these questions were strategicallyplaced after less sensitive topics. Additionally, gaps were identified, including missingquestions on traditional fertility practices (e.g., herbal remedies), male pubertycharacteristics, and partner support during and after childbirth. Addressing thesegaps by incorporating local beliefs and traditions will enable a more holisticunderstanding of reproductive health behaviors. Furthermore, translations overlooked subtle linguistic nuances, highlighting the need for more detailed explanations oralternative concepts in Swahili to ensure clarity and accuracy.

Conclusion: The Fember-Africa study aims to bridge a critical gap in understandingsex- and gender-specific differences in Africa, shedding light on the disproportionatelyhigher prevalence of dementia among women of African ancestry. Through theculturally sensitive adaptation of reproductive health assessment tool, the studyseeks to generate valuable insights that can inform the prevention and managementof Alzheimer’s disease and related dementias (ADRD) in this underrepresentedpopulation.

AKU Student

no

Publication (Name of Journal)

Alzheimer's & Dementia

DOI

https://doi.org/10.1002/alz70858_104321

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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