Document Type
Article
Department
Brain and Mind Institute
Abstract
Children born to mothers infected by Zika virus (ZIKV) during pregnancy are at increased risk of adverse neurodevelopmental outcomes including microcephaly, epilepsy, and neurocognitive deficits, collectively known as Congenital Zika Virus Syndrome. To study the impact of ZIKV on infant brain development, we collected resting-state electroencephalography (EEG) recordings from 28 normocephalic ZIKV-exposed children and 16 socio-demographically similar but unexposed children at 23–27 months of age. We assessed group differences in frequency band power and brain synchrony, as well as the relationship between these metrics and age. A significant difference (p < 0.05, Bonferroni corrected) in Inter-Site Phase Coherence was observed: median Pearson correlation coefficients were 0.15 in unexposed children and 0.07 in ZIKV-exposed children. Results showed that functional brain networks in the unexposed group were developing rapidly, in part by strengthening distal high-frequency and weakening proximal lower frequency connectivity, presumably reflecting normal synaptic growth, myelination and pruning. These maturation patterns were attenuated in the ZIKV-exposed group, suggesting that ZIKV exposure may contribute to neurodevelopmental vulnerabilities that can be detected and quantified by resting-state EEG.
Publication (Name of Journal)
Scientific Reports
DOI
https://doi.org/10.1038/s41598-025-90860-0
Recommended Citation
Omurtag, A.,
Abdulbaki, S.,
Thesen, T.,
Waechter, R.,
Landon, B.,
Evans, R.,
Dlugos, D.,
Chari, G.,
Desiree LaBeaud, A.,
Blackmon, K.
(2025). Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG. Scientific Reports, 15(6346), 1-14.
Available at:
https://ecommons.aku.edu/bmi/453
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
