Proportion and determination of medication adherence failure among patients after coronary artery bypass grafting at a tertiary care hospital in Karachi, Pakistan: An analytical cross sectional study

Date of Award


Document Type


Degree Name

Master of Science in Epidemiology & Biostatistics (MSc Epidemiology & Biostats)


Community Health Sciences


Medication adherence failure worldwide. It adds burden on The primary objective of this associated with it. (MAP) after coronary artery bypass grafting is the major issue the healthcare system and results in the poor health outcomes. study is to estimate the proportion of MAF, and the factors Aim: The aim of this study was to determine the proportion of medication adherence failu !he associated factors among the coronary artery bypass grafting patients re and Alaterials and Methods: This study was a hospital based cross-sectional study. A sample of (n-60) patients was obtained from the consulting clinics after at least 3 months of CABG, using a consecutive sampling technique. The adult patients undergoing elective isolated CABG at Aga Khan University Hospital were included. The study was conducted from June till September 2019. The medication adherence failure (outcome) was assessed using the Morisky scale 8. The data collected comprised of the patient's demographics, family history of diseases, co the number of medications and the severity of symptoms. The data was analyzed Using the cox proportional algorithm. Results: The mean age of the participants was 5 9.9(±10.1) and (86.6%) were males. In 33.3% of the individuals the medication adherence failure was present with forgetting to take medi the frequently reported reason (48.3%). cations Multivariable regression analysis showed that the factors associated with the MAF include NYHA functional' class (PR-0.02, 95% C1=-0.0005 - 1.01), Education Up to Matric (PR--4.49, 95% CI=-1.15 - 17.58), Intermediate (PR=8.44, 95% CI= 2.002 - 35.64), Age (PR-0.93, 95% C1--0.88 - 0.97) and number of medications (PR=1.17, 95% C1=-1.04 - 1.32). onclusion: Our study that the prevalence of MAF is associated with the low education level, greater number of medications and younger age. increasing the medication adherence will help in preventing the complications and repeat coronary procedures. Furthermore, appropriate interventions could be planned to address the behaviors related to taking medications.

This document is available in the relevant AKU library