Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions
Document Type
Review Article
Department
Office of the Provost; Cardiology
Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.
Publication (Name of Journal)
Progress in Cardiovascular Diseases
DOI
10.1016/j.pcad.2024.09.001
Recommended Citation
Gajagowni, S.,
Hopkins, S.,
Qadeer, Y.,
Virani, S. S.,
Verdonschot, J. A.,
Coombs, C. C.,
Amos, C. I.,
Nead, K. T.,
Jaiswal, S.,
Krittanawong, C.
(2024). Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions. Progress in Cardiovascular Diseases.
Available at:
https://ecommons.aku.edu/provost_office/812
Comments
Volume, issue and pagination are not provided by the author/publisher.