Title
The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis
Document Type
Review Article
Department
Cardiology
Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that belongs to the superfamily of phospholipase A2 enzymes. Although initial studies showed that Lp-PLA2 might be protective against atherosclerosis, emerging data seem to suggest that Lp-PLA2 may be proatherogenic, which is an effect thought to be mediated by lysophosphatidylcholine and oxidized nonesterified fatty acids, two mediators generated by Lp-PLA2. This article reviews the potential mechanisms by which Lp-PLA2 may participate in the pathogenesis of atherosclerosis and its clinical manifestations, namely, coronary artery disease and stroke.
Publication ( Name of Journal)
Current Atherosclerosis Reports
Recommended Citation
Virani, S. S.,
Nambi, V.
(2007). The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis. Current Atherosclerosis Reports, 9(2), 97-103.
Available at:
https://ecommons.aku.edu/provost_office/307
Comments
This work was published before the author joined Aga Khan University.