The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis

Authors

Salim S. Virani, Baylor College of Medicine, United StatesFollow
Vijay Nambi, Baylor College of Medicine, United States

Document Type

Review Article

Department

Cardiology

Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that belongs to the superfamily of phospholipase A2 enzymes. Although initial studies showed that Lp-PLA2 might be protective against atherosclerosis, emerging data seem to suggest that Lp-PLA2 may be proatherogenic, which is an effect thought to be mediated by lysophosphatidylcholine and oxidized nonesterified fatty acids, two mediators generated by Lp-PLA2. This article reviews the potential mechanisms by which Lp-PLA2 may participate in the pathogenesis of atherosclerosis and its clinical manifestations, namely, coronary artery disease and stroke.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Current Atherosclerosis Reports

Recommended Citation

Virani, S. S., Nambi, V. (2007). The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis. Current Atherosclerosis Reports, 9(2), 97-103.
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